Search Results - "Gaboriau, David"

The connecting cilium inner scaffold provides a structural foundation that protects against retinal degeneration by Mercey, Olivier, Kostic, Corinne, Bertiaux, Eloïse, Giroud, Alexia, Sadian, Yashar, Gaboriau, David C A, Morrison, Ciaran G, Chang, Ning, Arsenijevic, Yvan, Guichard, Paul, Hamel, Virginie

“…Inherited retinal degeneration due to loss of photoreceptor cells is a leading cause of human blindness. These cells possess a photosensitive outer segment…”
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Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour by Akram, Khondoker M., Yates, Laura L., Mongey, Róisín, Rothery, Stephen, Gaboriau, David C. A., Sanderson, Jeremy, Hind, Matthew, Griffiths, Mark, Dean, Charlotte H.

“…Damage to alveoli, the gas-exchanging region of the lungs, is a component of many chronic and acute lung diseases. In addition, insufficient generation of…”
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Content-aware frame interpolation (CAFI): deep learning-based temporal super-resolution for fast bioimaging by Priessner, Martin, Gaboriau, David C. A., Sheridan, Arlo, Lenn, Tchern, Garzon-Coral, Carlos, Dunn, Alexander R., Chubb, Jonathan R., Tousley, Aidan M., Majzner, Robbie G., Manor, Uri, Vilar, Ramon, Laine, Romain F.

“…The development of high-resolution microscopes has made it possible to investigate cellular processes in 3D and over time. However, observing fast cellular…”
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Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum by Yahiya, Sabrina, Jordan, Sarah, Smith, Holly X, Gaboriau, David C A, Famodimu, Mufuliat T, Dahalan, Farah A, Churchyard, Alisje, Ashdown, George W, Baum, Jake

“…Formation of gametes in the malaria parasite occurs in the midgut of the mosquito and is critical to onward parasite transmission. Transformation of the male…”
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Investigation of the Thermogelation of a Promising Biocompatible ABC Triblock Terpolymer and Its Comparison with Pluronic F127 by Constantinou, Anna P, Nele, Valeria, Doutch, James J, S. Correia, Joana, Moiseev, Roman V, Cihova, Martina, Gaboriau, David C. A, Krell, Jonathan, Khutoryanskiy, Vitaliy V, Stevens, Molly M, Georgiou, Theoni K

“…Thermoresponsive polymers with the appropriate structure form physical networks upon changes in temperature, and they find utility in formulation science,…”
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Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis by Hewitt, Richard J., Puttur, Franz, Gaboriau, David C. A., Fercoq, Frédéric, Fresquet, Maryline, Traves, William J., Yates, Laura L., Walker, Simone A., Molyneaux, Philip L., Kemp, Samuel V., Nicholson, Andrew G., Rice, Alexandra, Roberts, Edward, Lennon, Rachel, Carlin, Leo M., Byrne, Adam J., Maher, Toby M., Lloyd, Clare M.

“…Aberrant expansion of KRT5 + basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in…”
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Graphene Sensor Arrays for Rapid and Accurate Detection of Pancreatic Cancer Exosomes in Patients’ Blood Plasma Samples by Yin, Tianyi, Xu, Lizhou, Gil, Bruno, Merali, Nabeel, Sokolikova, Maria S., Gaboriau, David C. A., Liu, Daniel S. K., Muhammad Mustafa, Ahmad Nizamuddin, Alodan, Sarah, Chen, Michael, Txoperena, Oihana, Arrastua, María, Gomez, Juan Manuel, Ontoso, Nerea, Elicegui, Marta, Torres, Elias, Li, Danyang, Mattevi, Cecilia, Frampton, Adam E., Jiao, Long R., Ramadan, Sami, Klein, Norbert

“…Biosensors based on graphene field effect transistors (GFETs) have the potential to enable the development of point-of-care diagnostic tools for early stage…”
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Chloroplasts alter their morphology and accumulate at the pathogen interface during infection by Phytophthora infestans by Savage, Zachary, Duggan, Cian, Toufexi, Alexia, Pandey, Pooja, Liang, Yuxi, Segretin, María Eugenia, Yuen, Lok Him, Gaboriau, David C. A., Leary, Alexandre Y., Tumtas, Yasin, Khandare, Virendrasinh, Ward, Andrew D., Botchway, Stanley W., Bateman, Benji C., Pan, Indranil, Schattat, Martin, Sparkes, Imogen, Bozkurt, Tolga O.

“…Summary Upon immune activation, chloroplasts switch off photosynthesis, produce antimicrobial compounds and associate with the nucleus through tubular…”
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Chemical biology tools for probing transcytosis at the blood-brain barrier by Beard, Rhiannon, Gaboriau, David C. A, Gee, Antony D, Tate, Edward W

“…Absorptive- and receptor-mediated transcytosis (AMT/RMT) are widely studied strategies to deliver therapeutics across the blood-brain barrier (BBB). However,…”
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The acid injury and repair (AIR) model: A novel ex-vivo tool to understand lung repair by Kim, Sally Yunsun, Mongey, Róisín, Wang, Peizhu, Rothery, Stephen, Gaboriau, David C.A., Hind, Matthew, Griffiths, Mark, Dean, Charlotte H.

“…Research into mechanisms underlying lung injury and subsequent repair responses is currently of paramount importance. There is a paucity of models that bridge…”
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Rationally-engineered reproductive barriers using CRISPR & CRISPRa: an evaluation of the synthetic species concept in Drosophila melanogaster by Waters, Andrew J., Capriotti, Paolo, Gaboriau, David C. A., Papathanos, Philippos Aris, Windbichler, Nikolai

“…The ability to erect rationally-engineered reproductive barriers in animal or plant species promises to enable a number of biotechnological applications such…”
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Spatiotemporal dynamics of HSV genome nuclear entry and compaction state transitions using bioorthogonal chemistry and super-resolution microscopy by Sekine, Eiki, Schmidt, Nora, Gaboriau, David, O'Hare, Peter

“…We investigated the spatiotemporal dynamics of HSV genome transport during the initiation of infection using viruses containing bioorthogonal traceable…”
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Effect of the CXCR4 antagonist plerixafor on endogenous neutrophil dynamics in the bone marrow, lung and spleen by Pillay, Janesh, Tregay, Nicola, Juzenaite, Goda, Carlin, Leo M., Pirillo, Chiara, Gaboriau, David C. A., Farahi, Neda, Summers, Charlotte, Lo Celso, Cristina, Chilvers, Edwin R., Rankin, Sara, De Filippo, Katia

“…Treatment with the CXCR4 antagonist, plerixafor (AMD3100), has been proposed for clinical use in patients with WHIM (warts, hypogammaglobulinemia, infections,…”
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Calm on the surface, dynamic on the inside. Molecular homeostasis of Anabaena sp. PCC 7120 nitrogen metabolism by Perin, Giorgio, Fletcher, Tyler, Sagi‐Kiss, Virag, Gaboriau, David C. A., Carey, Mathew R., Bundy, Jacob G., Jones, Patrik R.

“…Nitrogen sources are all converted into ammonium/ia as a first step of assimilation. It is reasonable to expect that molecular components involved in the…”
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Centrobin controls primary ciliogenesis in vertebrates by Ogungbenro, Yetunde Adesanya, Tena, Teresa Casar, Gaboriau, David, Lalor, Pierce, Dockery, Peter, Philipp, Melanie, Morrison, Ciaran G

“…The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing…”
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Bioreactor analyses of tissue ingrowth, ongrowth and remodelling around implants: An alternative to live animal testing by Kohli, Nupur, Theodoridis, Konstantinos, Hall, Thomas A G, Sanz-Pena, Inigo, Gaboriau, David C A, van Arkel, Richard J

“…Preclinical assessment of bone remodelling onto, into or around novel implant technologies is underpinned by a large live animal testing burden. The aim of…”
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DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors by Rainey, Michael D, Quachthithu, Huong, Gaboriau, David, Santocanale, Corrado

“…The CDC7 kinase, by phosphorylating the MCM DNA helicase, is a key switch for DNA replication initiation. ATP competitive CDC7 inhibitors are being developed…”
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A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens by Ashdown, George W, Dimon, Michelle, Fan, Minjie, Sánchez-Román Terán, Fernando, Witmer, Kathrin, Gaboriau, David C A, Armstrong, Zan, Ando, D Michael, Baum, Jake

“…Drug resistance threatens the effective prevention and treatment of an ever-increasing range of human infections. This highlights an urgent need for new and…”
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Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity by Gaboriau, David C A, Rowling, Pamela J E, Morrison, Ciaran G, Itzhaki, Laura S

“…Mutations in breast cancer susceptibility gene BRCA1 (breast cancer early-onset 1) are associated with increased risk of developing breast and ovarian cancers…”
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Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification by Flanagan, Anne-Marie, Stavenschi, Elena, Basavaraju, Shivakumar, Gaboriau, David, Hoey, David A, Morrison, Ciaran G

“…Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome numbers can impair cell division and cause changes in how cells migrate…”
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