Search Results - "Gabius, H J"

Sweet complementarity: the functional pairing of glycans with lectins by Gabius, H.-J., Manning, J. C., Kopitz, J., André, S., Kaltner, H.

“…Carbohydrates establish the third alphabet of life. As part of cellular glycoconjugates, the glycans generate a multitude of signals in a minimum of space. The…”
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How to Crack the Sugar Code by Gabius, H-J

“…The known ubiquitous presence of glycans fulfils an essential prerequisite for fundamental roles in cell sociology. Since carbohydrates are chemically…”
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The Dysregulated Galectin Network Activates NF-κB to Induce Disease Markers and Matrix Degeneration in 3D Pellet Cultures of Osteoarthritic Chondrocytes by Pichler, K. M., Weinmann, D., Schmidt, S., Kubista, B., Lass, R., Martelanz, L., Alphonsus, J., Windhager, R., Gabius, H. -J., Toegel, S.

“…This work aimed to study the dysregulated network of galectins in OA chondrocyte pellets, and to assess whether their recently discovered activity as molecular…”
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Increased expression of distinct galectins in multiple sclerosis lesions by Stancic, M., van Horssen, J., Thijssen, V. L., Gabius, H.-J., van der Valk, P., Hoekstra, D., Baron, W.

“…M. Stancic, J. van Horssen, V. L. Thijssen, H.‐J. Gabius, P. van der Valk, D. Hoekstra and W. Baron (2011) Neuropathology and Applied Neurobiology37, 654–671…”
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Localization of Galectins within Glycocalyx by Rapoport, E. M., Matveeva, V. K., Vokhmyanina, O. A., Belyanchikov, I. M., Gabius, H.-J., Bovin, N. V.

“…Galectins are involved in various biological processes, e.g. cell–cell and cell–matrix adhesion and the transmission of cellular signals. Despite the diversity…”
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X-ray reflectivity and grazing incidence diffraction studies of interaction between human adhesion/growth-regulatory galectin-1 and DPPE—GM1 lipid monolayer at an air/water interface by Majewski, J., André, S., Jones, E., Chi, E., Gabius, H.-J.

“…The specific interaction of ganglioside GM1 with the homodimeric (prototype) endogenous lectin galectin-1 triggers growth regulation in tumor and activated…”
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Galectin fingerprinting in human endometrium and decidua during the menstrual cycle and in early gestation by von Wolff, M., Wang, X., Gabius, H.-J., Strowitzki, T.

“…The emerging functionality of the sugar code via cell surface glycans and endogenous lectins ascribes pertinent roles in cell physiology to the carbohydrate…”
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Galectin fingerprinting detects differences in expression profiles between bovine endometrium and placentomes as well as early and late gestational stages by Froehlich, R, Hambruch, N, Haeger, J.-D, Dilly, M, Kaltner, H, Gabius, H.-J, Pfarrer, C

“…Abstract The concept of a network within the family of adhesion/growth regulatory galectins implies distinct spatio-temporal expression profiles. To test this…”
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Eukaryotic glycosylation: whim of nature or multipurpose tool? by Reuter, G, Gabius, H J

“…Protein and lipid glycosylation is a ubiquitous phenomenon. The task of cataloguing the great structural variety of the glycan part has demanded considerable…”
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Human tandem-repeat-type galectins bind bacterial non-βGal polysaccharides by Knirel, Yu. A., Gabius, H.-J., Blixt, O., Rapoport, E. M., Khasbiullina, N. R., Shilova, N. V., Bovin, N. V.

“…Galectins are multifunctional effectors, for example acting as regulators of cell growth via protein-glycan interactions. The observation of capacity to kill…”
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Increased galectin-3 expression and intra-epithelial neutrophils in small airways in severe COPD by Pilette, C, Colinet, B, Kiss, R, Andre, S, Kaltner, H, Gabius, H-J, Delos, M, Vaerman, J-P, Decramer, M, Sibille, Y

“…Galectins-1 and -3 regulate epithelial proliferation/apoptosis and neutrophil activation, and are implicated in lung cancer and asthma. The role of galectins…”
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Endogenous lectins as targets for drug delivery by Yamazaki, N., Kojima, S., Bovin, N.V., André, S., Gabius, S., Gabius, H.-J.

“…To minimize side effects of drugs it would be ideal to target them exclusively to those cell types which require treatment. As a means to this end prototypical…”
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Sensing ligand binding to a clinically relevant lectin by tryptophan fluorescence anisotropy by Göhler, Antonia, Büchner, Claudia, André, Sabine, Doose, Sören, Kaltner, Herbert, Gabius, H-J

“…Increasing insights into the involvement of endogenous lectins in disease processes fuel the interest to develop potent inhibitors. As a consequence, robust…”
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Increased expression and altered intracellular distribution of adhesion/growth-regulatory lectins galectins-1 and -7 during tumour progression in hypopharyngeal and laryngeal squamous cell carcinomas by Saussez, S, Decaestecker, C, Lorfevre, F, Chevalier, D, Mortuaire, G, Kaltner, H, André, S, Toubeau, G, Gabius, H-J, Leroy, X

“…Aims:  To examine the level of expression of the pleiotropic regulators galectins‐1 and ‐7 in relation to neoplastic progression of hypopharyngeal (HSCCs) and…”
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Stromal fibroblasts from basal cell carcinoma affect phenotype of normal keratinocytes by Lacina, L., Smetana Jr, K., Dvořánková, B., Pytlík, R., Kideryová, L., Kučerová, L., Plzáková, Z., Štork, J., Gabius, H-J., André, S.

“…Summary Background  Epithelial–mesenchymal interactions are important not only to direct the course of prenatal development of skin and its appendages but also…”
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Towards Functional Glycomics by Lectin Histochemistry: Strategic Probe Selection to Monitor Core and Branch‐end Substitutions and Detection of Cell‐type and Regional Selectivity in Adult Mouse Testis and Epididymis by Lohr, M, Kaltner, H, Schwartz‐Albiez, R, Sinowatz, F, Gabius, H.‐J

“…With 2 figures and 3 tables SUMMARY: The emerging insights into glycan functionality direct increasing attention to monitor core modifications of N‐glycans and…”
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Gene-expression signature of adhesion/growth-regulatory tissue lectins (galectins) in transitional cell cancer and its prognostic relevance by Langbein, S, Brade, J, Badawi, J K, Hatzinger, M, Kaltner, H, Lensch, M, Specht, K, André, S, Brinck, U, Alken, P, Gabius, H-J

“…Aims:  Lectins, and especially galectins, appear to be important in malignancy‐associated processes. The aim was to analyse comprehensively the presence of…”
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CD4+CD7 leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death by RAPPL, G, ABKEN, H, MUCHE, J. M, STERRY, W, TILGEN, W, ANDRE, S, KALTNER, H, UGUREL, S, GABIUS, H-J, REINHOLD, U

“…In early stages of cutaneous T cell lymphoma (Sézary syndrome) both CD4+CD7- and CD4+CD7+ T cells clonally expand whereas in late stages of the disease CD7-…”
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Galectins promote the interaction of influenza virus with its target cell by Chernyy, E. S., Rapoport, E. M., Andre, S., Kaltner, H., Gabius, H. -J., Bovin, N. V.

“…Influenza virus is known to bind sialoglycans located on the surface of the host cell. In addition, recent data suggest the involvement of other molecular…”
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Carbohydrate specificity of chicken and human tandem-repeat-type galectins-8 in composition of cells by Vokhmyanina, O. A., Rapoport, E. M., Ryzhov, I. M., Korchagina, E. Yu, Pazynina, G. V., Severov, V. V., Kaltner, H., André, S., Gabius, H. -J., Bovin, N. V.

“…The network of adhesion/growth-regulatory galectins in chicken (chicken galectin, CG) has only one tandemrepeat-type protein, CG8. Using a cell-based assay and…”
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