Search Results - "Gabilondo, Ane M."
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HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
Published in Nature neuroscience (01-09-2012)“…The authors show that chronic treatment with antipsychotic drugs decreases expression of mGlu2 and histone acetylation at its promoter in frontal cortex. This…”
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2
Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers
Published in Neuropharmacology (01-02-2012)“…Opiate addiction is characterized by drug tolerance and dependence which involve adaptive changes in μ-opioid receptors (MORs) signaling. Regulators of…”
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3
Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: Selective biased agonism via Gαi1-proteins
Published in European neuropsychopharmacology (01-12-2019)“…Serotonin 5-HT2A receptors (5-HT2ARs) have been implicated in schizophrenia. However, postmortem studies on 5-HT2ARs expression and functionality in…”
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4
α2A- and α2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects
Published in European neuropsychopharmacology (01-11-2021)“…•α2A- and α2C-adrenoceptor protein expression was determined by Western Blot in the postmortem prefrontal cortex of 24 subjects with schizophrenia and 24…”
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5
Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [ 35 S]GTPγS binding assays combined with immunoprecipitation
Published in Pharmacological reports (01-08-2021)“…G-protein-coupled receptors (GPCRs) have an enormous biochemical importance as they bind to diverse extracellular ligands and regulate a variety of…”
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6
Spinophilin expression in postmortem prefrontal cortex of schizophrenic subjects: Effects of antipsychotic treatment
Published in European neuropsychopharmacology (01-01-2021)“…•Spinophilin protein expression was determined by western blot in DLPFC of 24 schizophrenia subjects and 24 matched controls.•Experiments were performed in…”
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7
Differential α 2A - and α 2C -adrenoceptor protein expression in presynaptic and postsynaptic density fractions of postmortem human prefrontal cortex
Published in Journal of psychopharmacology (Oxford) (01-02-2019)“…Three different α -adrenoceptor (α -AR) subtypes have been described. The α -AR and α -AR subtypes are highly expressed in the human prefrontal cortex, where…”
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Increased α2 - and β1 -adrenoceptor densities in postmortem brain of subjects with depression: Differential effect of antidepressant treatment
Published in Journal of affective disorders (01-10-2014)“…Abstract Background Brain α2 - and β-adrenoceptor alterations have been suggested in suicide and major depressive disorder. Methods The densities of α2 -, β1 -…”
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9
Up-regulated 14-3-3β and 14-3-3ζ proteins in prefrontal cortex of subjects with schizophrenia: effect of psychotropic treatment
Published in Schizophrenia research (01-02-2015)“…Abstract 14-3-3 is a family of conserved regulatory proteins that bind to a multitude of functionally diverse signalling proteins. Various genetic studies and…”
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10
Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence
Published in The world journal of biological psychiatry (01-06-2016)“…Objectives α2C-adrenoceptors (α2C-AR) are involved in behavioural responses relevant to psychiatric disorders and suicide completion. The genetic polymorphism…”
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11
Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the μ-opioid receptor and I2–imidazoline binding sites
Published in Bioorganic & medicinal chemistry (01-10-2006)“…Two series of fentanyl-derived hybrid molecules bearing potent I2–imidazoline binding site (IBS) ligands (i.e., guanidine and BU224 moieties) linked with an…”
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12
Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain
Published in Neurochemistry international (01-12-2010)“…▶ Conditions for immunodetection of RGS4 and RGS10 proteins in postmortem human brain are given. ▶ RGS4 protein clearly predominates in plasma membrane and…”
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13
Monoamine oxidase B activity is increased in human gliomas
Published in Neurochemistry international (01-01-2008)“…Glial tumours are the most common type of brain neoplasm in humans. Tumour classification and grading represent key factors for patient management. However,…”
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A Dileucine Motif in the C Terminus of the β2-adrenergic Receptor is Involved in Receptor Internalization
Published in Proceedings of the National Academy of Sciences - PNAS (11-11-1997)“…The cytoplasmic C terminus of the β2-adrenergic receptor and many other G protein-coupled receptors contains a dileucine sequence that has been implicated in…”
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15
Characterization of receptor-mediated [ 35S]GTPγS binding to cortical membranes from postmortem human brain
Published in European journal of pharmacology (25-02-2000)“…The [ 35S]GTPγS binding assay represents a functional approach to assess the coupling between receptors and G-proteins. The optimal conditions for [ 35S]GTPγS…”
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Differential α2A- and α2C-adrenoceptor protein expression in presynaptic and postsynaptic density fractions of postmortem human prefrontal cortex
Published in Journal of psychopharmacology (Oxford) (01-02-2019)“…Background: Three different α2-adrenoceptor (α2-AR) subtypes have been described. The α2A-AR and α2C-AR subtypes are highly expressed in the human prefrontal…”
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17
α 2A - and α 2C -adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects
Published in European neuropsychopharmacology (01-11-2021)“…Previous evidence suggests that α -adrenoceptors (α -AR) may be involved in the pathophysiology of schizophrenia. However, postmortem brain studies on α -AR…”
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18
Serotonin 5-HT 2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: Selective biased agonism via G αi1 -proteins
Published in European neuropsychopharmacology (01-12-2019)“…Serotonin 5-HT receptors (5-HT Rs) have been implicated in schizophrenia. However, postmortem studies on 5-HT Rs expression and functionality in schizophrenia…”
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19
Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu -opioid receptor and I sub(2)-imidazoline binding sites
Published in Bioorganic & medicinal chemistry (01-10-2006)“…Two series of fentanyl-derived hybrid molecules bearing potent I sub(2)- imidazoline binding site (IBS) ligands (i.e., guanidine and BU224 moieties) linked…”
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20
Increased density of μ-opioid receptors in the postmortem brain of suicide victims
Published in Brain research (05-06-1995)“…The biochemical status of μ-opioid receptors in suicide was evaluated by [ 3H]DAGO specific binding in postmortem human brains from 15 suicide victims and 15…”
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