Search Results - "Gabdoulline, R"

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis by Shi, Y, Nikulenkov, F, Zawacka-Pankau, J, Li, H, Gabdoulline, R, Xu, J, Eriksson, S, Hedström, E, Issaeva, N, Kel, A, Arnér, E S J, Selivanova, G

“…Rescue of the p53 tumor suppressor is an attractive cancer therapy approach. However, pharmacologically activated p53 can induce diverse responses ranging from…”
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sROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis by Shi, Y, Nikulenkov, F, Zawacka-Pankau, J, Li, H, Gabdoulline, R, Xu, J, Eriksson, S, Hedstroem, E, Issaeva, N, Kel, A

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Brownian Dynamics Simulation of Protein Solutions: Structural and Dynamical Properties by Mereghetti, Paolo, Gabdoulline, Razif R., Wade, Rebecca C.

“…The study of solutions of biomacromolecules provides an important basis for understanding the behavior of many fundamental cellular processes, such as protein…”
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Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo by Chaturvedi, A, Herbst, L, Pusch, S, Klett, L, Goparaju, R, Stichel, D, Kaulfuss, S, Panknin, O, Zimmermann, K, Toschi, L, Neuhaus, R, Haegebarth, A, Rehwinkel, H, Hess-Stumpp, H, Bauser, M, Bochtler, T, Struys, E A, Sharma, A, Bakkali, A, Geffers, R, Araujo-Cruz, M M, Thol, F, Gabdoulline, R, Ganser, A, Ho, A D, von Deimling, A, Rippe, K, Heuser, M, Krämer, A

“…Neomorphic mutations in isocitrate dehydrogenase 1 ( IDH1 ) are frequently found in several human cancer types including acute myeloid leukemia (AML) and lead…”
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Differences in the Early Development of Human and Mouse Embryonic Stem Cells by Gabdoulline, R, Kaisers, W, Gaspar, A, Meganathan, K, Doss, M X, Jagtap, S, Hescheler, J, Sachinidis, A, Schwender, H

“…We performed a systematic analysis of gene expression features in early (10-21 days) development of human vs mouse embryonic cells (hESCs vs mESCs). Many…”
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Protein-protein association: investigation of factors influencing association rates by Brownian dynamics simulations by Gabdoulline, Razif R., Wade, Rebecca C.

“…The rate of protein-protein association limits the response time due to protein-protein interactions. The bimolecular association rate may be…”
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webPIPSA: a web server for the comparison of protein interaction properties by Richter, Stefan, Wenzel, Anne, Stein, Matthias, Gabdoulline, Razif R, Wade, Rebecca C

“…Protein molecular interaction fields are key determinants of protein functionality. PIPSA (Protein Interaction Property Similarity Analysis) is a procedure to…”
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3DTF: a web server for predicting transcription factor PWMs using 3D structure-based energy calculations by Gabdoulline, R, Eckweiler, D, Kel, A, Stegmaier, P

“…We present the webserver 3D transcription factor (3DTF) to compute position-specific weight matrices (PWMs) of transcription factors using a knowledge-based…”
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Biomolecular diffusional association by Gabdoulline, Razif R., Wade, Rebecca C.

“…The primary method for the computational study of biomolecular diffusional association is Brownian dynamics. Recent work has seen advances in the efficiency of…”
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Diffusional Encounter of Barnase and Barstar by Spaar, Alexander, Dammer, Christian, Gabdoulline, Razif R., Wade, Rebecca C., Helms, Volkhard

“…We present an analysis of trajectories from Brownian dynamics simulations of diffusional protein-protein encounter for the well-studied system of barnase and…”
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Computer simulation of protein-protein association kinetics: acetylcholinesterase-fasciculin by Elcock, Adrian H, Gabdoulline, Razif R, Wade, Rebecca C, McCammon, J.Andrew

“…Computer simulations were performed to investigate the role of electrostatic interactions in promoting fast association of acetylcholinesterase with its…”
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How Optimal Are the Binding Energetics of Barnase and Barstar? by Wang, Ting, Tomic, Sanja, Gabdoulline, Razif R., Wade, Rebecca C.

“…The extracellular ribonuclease barnase and its intracellular inhibitor barstar bind fast and with high affinity. Although extensive experimental and…”
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Electrostatic Steering and Ionic Tethering in Enzyme-Ligand Binding: Insights from Simulations by Wade, Rebecca C., Gabdoulline, Razif R., Ludemann, Susanna K., Lounnas, Valere

“…To bind at an enzyme's active site, a ligand must diffuse or be transported to the enzyme's surface, and, if the binding site is buried, the ligand must…”
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Simulation of the diffusional association of barnase and barstar by Gabdoulline, R.R., Wade, R.C.

“…The rate of protein association places an upper limit on the response time due to protein interactions, which, under certain circumstances, can be…”
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P468: MRD AS A BIOMARKER FOR RESPONSE TO DONOR LYMPHOCYTE INFUSION AFTER AL‐LOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION IN PATIENTS WITH ACUTE MYELOID LEUKEMIA by Teich, K., Stadler, M., Gabdoulline, R., Wienecke, C., Heida, B., Klement, P., Büttner, K., Venturini, L., Wichmann, M., Puppe, W., Schultze‐Florey, C., Beutel, G., Eder, M., Ganser, A., Heuser, M., Thol, F.

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MolSurfer: a macromolecular interface navigator by Gabdoulline, Razif R., Wade, Rebecca C., Walther, Dirk

“…We describe the current status of the Java molecular graphics tool, MolSurfer. MolSurfer has been designed to assist the analysis of the structures and…”
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Brownian Dynamics Simulation of Protein–Protein Diffusional Encounter by Gabdoulline, Razif R., Wade, Rebecca C.

“…Protein association events are ubiquitous in biological systems. Some protein associations and subsequent responses are diffusion controlledin vivo.Hence, it…”
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qPIPSA: relating enzymatic kinetic parameters and interaction fields by Gabdoulline, Razif R, Stein, Matthias, Wade, Rebecca C

“…The simulation of metabolic networks in quantitative systems biology requires the assignment of enzymatic kinetic parameters. Experimentally determined values…”
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Comparison of the Binding and Reactivity of Plant and Mammalian Peroxidases to Indole Derivatives by Computational Docking by Hallingbäck, Henrik R., Gabdoulline, Razif R., Wade, Rebecca C.

“…The oxidation of melatonin by the mammalian myeloperoxidase (MPO) provides protection against the damaging effects of reactive oxygen species. Indole…”
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Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis by Thol, F, Klesse, S, Köhler, L, Gabdoulline, R, Kloos, A, Liebich, A, Wichmann, M, Chaturvedi, A, Fabisch, J, Gaidzik, V I, Paschka, P, Bullinger, L, Bug, G, Serve, H, Göhring, G, Schlegelberger, B, Lübbert, M, Kirchner, H, Wattad, M, Kraemer, D, Hertenstein, B, Heil, G, Fiedler, W, Krauter, J, Schlenk, R F, Döhner, K, Döhner, H, Ganser, A, Heuser, M

“…We studied acute myeloid leukemia (AML) patients with lympho-myeloid clonal hematopoiesis (LM-CH), defined by the presence of DNA methyltransferase 3A ( DNMT3A…”
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