Search Results - "Gabbay, K. H."

The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases by BOHREN, K. M, BULLOCK, B, WERMUTH, B, GABBAY, K. H

“…Aldehyde reductase [EC 1.1.1.2] and aldose reductase [EC 1.1.1.21] are monomeric NADPH-dependent oxidoreductases having wide substrate specificities for…”
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The search for IDDM susceptibility genes: the next generation by Owerbach, D., Gabbay, K. H.

“…The search for IDDM susceptibility genes: the next generation. D Owerbach and K H Gabbay Department of Pediatrics, Baylor College of Medicine, Houston, TX…”
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Retinal circulatory abnormalities in type 1 diabetes by Feke, GT, Buzney, SM, Ogasawara, H, Fujio, N, Goger, DG, Spack, NP, Gabbay, KH

“…To quantify retinal circulatory abnormalities in patients with type 1 diabetes; to 1 diabetes; to compare blood speed and blood flow in major temporal retinal…”
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An Unlikely Sugar Substrate Site in the 1.65 Å Structure of the Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications by Wilson, David K., Bohren, Kurt M., Gabbay, Kenneth H., Quiocho, Florante A.

“…Aldose reductase, which catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and…”
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Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene by Owerbach, D., Gabbay, K. H.

“…Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene. D Owerbach and K H Gabbay Diabetes…”
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Characterization of the Osmotic Response Element of the Human Aldose Reductase Gene Promoter by Ruepp, Barbara, Bohren, Kurt M., Gabbay, Kenneth H.

“…Aldose reductase (EC 1.1.1.21) catalyzes the NADPH-mediated conversion of glucose to sorbitol. The hyperglycemia of diabetes increases sorbitol production…”
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Tyrosine-48 Is the Proton Donor and Histidine-110 Directs Substrate Stereochemical Selectivity in the Reduction Reaction of Human Aldose Reductase: Enzyme Kinetics and Crystal Structure of the Y48H Mutant Enzyme by Bohren, Kurt M, Grimshaw, Charles E, Lai, Chung Jeng, Harrison, David H, Ringe, Dagmar, Petsko, Gregory A, Gabbay, Kenneth H

“…The active site of human aldose reductase contains two residues, His110 and Tyr48, either of which could be the proton donor during catalysis. Tyr48 is a…”
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Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein by Wermuth, B, Bohren, K M, Heinemann, G, von Wartburg, J P, Gabbay, K H

“…Carbonyl reductase (EC 1.1.1.184) is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds that are…”
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An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for the Binding of Citrate, Cacodylate, and Glucose 6-Phosphate by Harrison, David H, Bohren, Kurt M, Ringe, Dagmar, Petsko, Gregory A, Gabbay, Kenneth H

“…Aldose reductase is a NADPH-dependent aldo-keto reductase involved in the pathogenesis of some diabetic and galactosemic complications. The published crystal…”
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Characterization of the human aldose reductase gene promoter by Wang, K, Bohren, K M, Gabbay, K H

“…The promoter region of the human aldose reductase gene has been identified upstream of the translation start ATG codon. The promoter contains a TATA box, a…”
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Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain by BOHREN, K. M, GRIMSHAW, C. E, GABBAY, K. H

“…Human aldose reductase and aldehyde reductase are members of the aldo-keto reductase superfamily that share three domains of homology and a nonhomologous…”
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Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262 by BOHREN, K. M, PAGE, J. L, SHANKAR, R, HENRY, S. P, GABBAY, K. H

“…Human aldose reductase (EC 1.1.1.21) and aldehyde reductase (EC 1.1.1.2) are implicated in the development of diabetic complications by a variety of…”
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Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver by Roberts, C T, Brown, A L, Graham, D E, Seelig, S, Berry, S, Gabbay, K H, Rechler, M M

“…Insulin-like growth factor I (IGF-I) is a mitogenic polypeptide present in the plasma of man and rat that is thought to mediate the actions of pituitary growth…”
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Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35 by Owerbach, D., Naya, F. J., Tsai, M. J., Allander, S. V., Powell, D. R., Gabbay, K. H.

“…Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35. D Owerbach , F J…”
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Characterization of the Human Aldehyde Reductase Gene and Promoter by Barski, Oleg A., Gabbay, Kenneth H., Bohren, Kurt M.

“…Aldehyde reductase (EC 1.1.1.2; AKR1A1) is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. To study…”
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Linkage of the VNTR/insulin-gene and type I diabetes mellitus : increased gene sharing in affected sibling pairs by OWERBACH, D, GABBAY, K. H

“…Ninety-six multiplex type I diabetic families were typed at the 5' flanking region of the insulin gene by using a PCR assay that better resolves the VNTR into…”
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Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells by HUFF, K. K, KAUFMAN, D, GABBAY, K. H, SPENCER, E. M, LIPPMAN, M. E, DICKSON, R. B

“…Somatomedin activity is required for proliferation of normal cells; recently somatomedin activity in the cellular environment was shown to be necessary for…”
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Primary association of HLA-DQw8 with type I diabetes in DR4 patients by OWERBACH, D, GUNN, S, GABBAY, K. H

“…DNA from 164 Caucasian type I (insulin-dependent) diabetic patients and 200 Caucasian nondiabetic control blood donors were analyzed by the polymerase chain…”
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The HOXD8 locus (2q31) is linked to type I diabetes : interaction with chromosome 6 and 11 disease susceptibility genes by OWERBACH, D, GABBAY, K. H

“…Type I diabetes susceptibility genes have been identified within the major histocompatibility complex (MHC) on chromosome 6p21.3 and near the VNTR/insulin…”
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Primary association of HLA-DQw8 with type I diabetes in DR4 patients by Owerbach, D., Gunn, S., Gabbay, K. H.

“…Primary association of HLA-DQw8 with type I diabetes in DR4 patients. D Owerbach , S Gunn and K H Gabbay Department of Pediatrics, Baylor College of Medicine,…”
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