Search Results - "Gaballa, Mohamed A"

HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation by Nural-Guvener, Hikmet F, Zakharova, Luidmila, Nimlos, James, Popovic, Snjezana, Mastroeni, Diego, Gaballa, Mohamed A

“…Interstitial fibrosis and fibrotic scar formation contribute to cardiac remodeling and loss of cardiac function in myocardial infarction (MI) and heart…”
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Transplantation of cardiac progenitor cell sheet onto infarcted heart promotes cardiogenesis and improves function by Zakharova, Liudmila, Mastroeni, Diego, Mutlu, Nezahet, Molina, Michelle, Goldman, Steven, Diethrich, Edward, Gaballa, Mohamed A.

“…Aims Cell-based therapy for myocardial infarction (MI) holds great promise; however, the ideal cell type and delivery system have not been established…”
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Cardiac explant-derived cells are regulated by Notch-modulated mesenchymal transition by Zakharova, Liudmila, Nural-Guvener, Hikmet, Gaballa, Mohamed A

“…Progenitor cell therapy is emerging as a novel treatment for heart failure. However the molecular mechanisms regulating the generation of cardiac progenitor…”
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Retrograde coronary vein infusion of cardiac explant–derived c-Kit+ cells improves function in ischemic heart failure by Zakharova, Liudmila, PhD, Nural-Guvener, Hikmet, PhD, Feehery, Lorraine, BS, Popovic, Snjezana, BS, Nimlos, James, BS, Gaballa, Mohamed A., PhD

“…Background Progenitor cells isolated from cardiac explant–derived cells improve cardiac function after myocardial infarction (MI). To fully realize the…”
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An electrically coupled tissue-engineered cardiomyocyte scaffold improves cardiac function in rats with chronic heart failure by Lancaster, Jordan J., MS, Juneman, Elizabeth, MD, Arnce, Sarah A., MMS, PA-C, Johnson, Nicholle M., BS, Qin, Yexian, PhD, Witte, Russell, PhD, Thai, Hoang, MD, Kellar, Robert S., PhD, Ek Vitorin, Jose, PhD, MD, Burt, Janis, PhD, Gaballa, Mohamed A., PhD, Bahl, Joseph J., PhD, Goldman, Steven, MD

“…Background Varying strategies are currently being evaluated to develop tissue-engineered constructs for the treatment of ischemic heart disease. This study…”
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Grafting an acellular 3-dimensional collagen scaffold onto a non-transmural infarcted myocardium induces neo-angiogenesis and reduces cardiac remodeling by Gaballa, Mohamed A, Sunkomat, Julia N E, Thai, Hoang, Morkin, Eugene, Ewy, Gordon, Goldman, Steven

“…This study was designed to determine whether tissue engineering could be used to reduce ventricular remodeling in a rat model of non-transmural,…”
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Do adult stem cells ameliorate the damaged myocardium? Human cord blood as a potential source of stem cells by Furfaro, Elise M K, Gaballa, Mohamed A

“…The heart does not mend itself after infarction. However, stem cells may revolutionize heart disease treatment. A vast and growing body of evidence indicates…”
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BACE1 levels are elevated in congestive heart failure by Nural-Guvener, Hikmet F., Mutlu, Nezahet, Gaballa, Mohamed A.

“…► Microglia are activated in the cortex of AMI and CHF rats. ► BACE1 levels are up-regulated in the cortex and hippocampus of CHF rats. ► VEGF levels are…”
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The potential of cord blood stem cells for use in regenerative medicine by Harris, David T, Badowski, Michael, Ahmad, Nafees, Gaballa, Mohamed A

“…It is estimated that up to 128 million individuals might benefit from regenerative medicine therapy, or almost 1 in 3 individuals in the US. If accurate, the…”
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Human umbilical cord blood stem cells, myocardial infarction and stroke by Copeland, Nathan, Harris, David, Gaballa, Mohamed A

“…Myocardial infarction (MI) and stroke are the first and third leading causes of death in the USA accounting for more than 1 in 3 deaths per annum. Despite…”
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Inhibition of Nitric Oxide Synthases, But Not Inducible Nitric Oxide Synthase, Selectively Worsens Left Ventricular Function After Successful Resuscitation From Cardiac Arrest in Swine by Dokken, Betsy B., Gaballa, Mohamed A., Hilwig, Ronald W., Berg, Robert A., Kern, Karl B., Sinert, Richard

“…Objectives Nitric oxide (NO) is a critical regulator of vascular tone and signal transduction in the cardiovascular system. NO is synthesized by three unique…”
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Transplantation of Epigenetically Modified Adult Cardiac c‐Kit+ Cells Retards Remodeling and Improves Cardiac Function in Ischemic Heart Failure Model by Zakharova, Liudmila, Nural-Guvener, Hikmet, Feehery, Lorraine, Popovic-Sljukic, Snjezana, Gaballa, Mohamed A.

“…The cardiogenic potential of cardiac c‐Kit+ cells through class I histone deacetylase (HDAC) inhibition was augmented and their therapeutic potency in the…”
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Chronic heart failure is associated with transforming growth factor beta-dependent yield and functional decline in atrial explant-derived c-Kit+ cells by Zakharova, Liudmila, Nural-Guvener, Hikmet, Nimlos, James, Popovic, Snjezana, Gaballa, Mohamed A

“…Cardiac c-Kit+ cells isolated from cardiac explant-derived cells modestly improve cardiac functions after myocardial infarction; however, their full potential…”
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Ventricular remodeling in heart failure by Gaballa, Mohamed A., Goldman, Steven

“…This review briefly highlights the major mechanisms of left ventricular (LV) remodeling following myocardial infarction in heart failure and presents novel…”
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Valsartan Therapy in Heart Failure After Myocardial Infarction: The Role of Endothelial Dependent Vasorelaxation by Thai, Hoang, Guarraia, David, Johnson, Nicholle, Goldman, Steven, Gaballa, Mohamed A

“…Angiotensin II receptor blockade (ARB) increases vasorelaxation in heart failure by enhancing endothelial nitric oxide (NO). To determine the effects of…”
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Myocardial cytokine IL-8 and nitric oxide synthase activity during and after resuscitation: Preliminary observations in regards to post-resuscitation myocardial dysfunction by Kern, Karl B, Berg, Robert A, Hilwig, Ronald W, Larson, Douglas F, Gaballa, Mohamed A

“…Summary Aim Increases in serum cytokines have been reported after successful resuscitation from prolonged ventricular fibrillation (VF). Pro-inflammatory…”
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Pretreatment with angiotensin receptor blockade prevents left ventricular dysfunction and blunts left ventricular remodeling associated with acute myocardial infarction by THAI, Hoang, CASTELLANO, Lisa, JUNEMAN, Elizabeth, PHAN, Huy, DO, Rose, GABALLA, Mohamed A, GOLDMAN, Steven

“…This study was designed to determine the effects of pretreatment with an angiotensin receptor blocker on left ventricular (LV) function and remodeling during…”
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Large Artery Remodeling During Aging: Biaxial Passive and Active Stiffness by Gaballa, Mohamed A, Jacob, Christopher T, Raya, Thomas E, Liu, Jia, Simon, Bruce, Goldman, Steven

“…To examine arterial mechanical changes during aging, pressure-radius and axial force-radius curves were measured in vivo in carotid arteries from 6- and…”
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Simvastatin restores endothelial NO-mediated vasorelaxation in large arteries after myocardial infarction by Bates, Kathryn, Ruggeroli, Charles E, Goldman, Steven, Gaballa, Mohamed A

“…Congestive heart failure (CHF) after myocardial infarction is associated with diminished endothelial nitric oxide (NO)-mediated vasorelaxation. The…”
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Ventricular fibrillation waveform characteristics are different in ischemic heart failure compared with structurally normal hearts by Indik, Julia H., Donnerstein, Richard L., Kern, Karl B., Goldman, Steven, Gaballa, Mohamed A., Berg, Robert A.

“…For prolonged VF, perfusion of the myocardium by pre-shock chest compressions can improve myocardial readiness for successful defibrillation. Characteristics…”
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