Search Results - "Gaballa, Abdallah"
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PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
Published in Nature communications (16-02-2024)“…In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in…”
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MYC multimers shield stalled replication forks from RNA polymerase
Published in Nature (London) (01-12-2022)“…Oncoproteins of the MYC family drive the development of numerous human tumours 1 . In unperturbed cells, MYC proteins bind to nearly all active promoters and…”
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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
Published in Molecular cell (06-01-2022)“…The MYCN oncoprotein drives the development of numerous neuroendocrine and pediatric tumors. Here we show that MYCN interacts with the nuclear RNA exosome, a…”
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MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma
Published in Cancer research (Chicago, Ill.) (15-08-2021)“…Deregulated expression of the MYC oncoprotein enables tumor cells to evade immune surveillance, but the mechanisms underlying this surveillance are poorly…”
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