Search Results - "Gaare, Johannes"

DNA Methylation Age Acceleration Is Not Associated with Age of Onset in Parkinson's Disease by Gaare, Johannes J., Brügger, Kim, Nido, Gonzalo S., Tzoulis, Charalampos

“…Background Epigenetic clocks using DNA methylation (DNAm) to estimate biological age have become popular tools in the study of neurodegenerative diseases…”
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Rare genetic variation in mitochondrial pathways influences the risk for Parkinson's disease by Gaare, Johannes J., Nido, Gonzalo S., Sztromwasser, Paweł, Knappskog, Per M., Dahl, Olav, Lund‐Johansen, Morten, Maple‐Grødem, Jodi, Alves, Guido, Tysnes, Ole‐Bjørn, Johansson, Stefan, Haugarvoll, Kristoffer, Tzoulis, Charalampos

“…ABSTRACT Background: Mitochondrial dysfunction plays a key role in PD, but the underlying molecular mechanisms remain unresolved. We hypothesized that the…”
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Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson’s disease by Gaare, Johannes J., Dölle, Christian, Brakedal, Brage, Brügger, Kim, Haugarvoll, Kristoffer, Nido, Gonzalo S., Tzoulis, Charalampos

“…Replenishing nicotinamide adenine dinucleotide (NAD) via supplementation of nicotinamide riboside (NR) has been shown to confer neuroprotective effects in…”
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No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson's disease by Gaare, Johannes J, Nido, Gonzalo S, Sztromwasser, Paweł, Knappskog, Per M, Dahl, Olav, Lund-Johansen, Morten, Alves, Guido, Tysnes, Ole-Bjørn, Johansson, Stefan, Haugarvoll, Kristoffer, Tzoulis, Charalampos

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Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci by Gaare, Johannes Jernqvist, Nido, Gonzalo, Dolle, Christian, Sztromwasser, Pawel, Alves, Guido, Tysnes, Ole-Bjorn, Haugarvoll, Kristoffer, Tzoulis, Charalampos

“…Parkinson disease (PD) is a complex neurodegenerative disorder influenced by both environmental and genetic factors. While genome wide association studies have…”
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Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology by SenGupta, Tanima, Palikaras, Konstantinos, Esbensen, Ying Q., Konstantinidis, Georgios, Galindo, Francisco Jose Naranjo, Achanta, Kavya, Kassahun, Henok, Stavgiannoudaki, Ioanna, Bohr, Vilhelm A., Akbari, Mansour, Gaare, Johannes, Tzoulis, Charalampos, Tavernarakis, Nektarios, Nilsen, Hilde

“…Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic…”
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Familial aggregation of Parkinson's disease may affect progression of motor symptoms and dementia: Family History of PD May Affect Progression by Gaare, Johannes Jernqvist, Skeie, Geir Olve, Tzoulis, Charalampos, Larsen, Jan Petter, Tysnes, Ole-Bjørn

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Familial aggregation of Parkinson's disease may affect progression of motor symptoms and dementia by Gaare, Johannes Jernqvist, Skeie, Geir Olve, Tzoulis, Charalampos, Larsen, Jan Petter, Tysnes, Ole‐Bjørn

“…ABSTRACT Background Familial aggregation has been described in PD of both early and late onset, but has not been studied in a true population‐based sample…”
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Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci by Johannes Jernqvist Gaare, Gonzalo Nido, Christian Dölle, Paweł Sztromwasser, Guido Alves, Ole-Bjørn Tysnes, Kristoffer Haugarvoll, Charalampos Tzoulis

“…Parkinson disease (PD) is a complex neurodegenerative disorder influenced by both environmental and genetic factors. While genome wide association studies have…”
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