Search Results - "Gaal, F. F."

Once-Weekly Semaglutide in Adults with Overweight or Obesity by Wilding, John P.H, Batterham, Rachel L, Calanna, Salvatore, Davies, Melanie, Van Gaal, Luc F, Lingvay, Ildiko, McGowan, Barbara M, Rosenstock, Julio, Tran, Marie T.D, Wadden, Thomas A, Wharton, Sean, Yokote, Koutaro, Zeuthen, Niels, Kushner, Robert F

“…This double-blind study randomly assigned adults with obesity (or overweight and with one or more weight-related coexisting conditions) without diabetes to 68…”
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Combating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes by Scheen, André J, Prof, Van Gaal, Luc F, Prof

“…Summary The increasing prevalence of obesity is contributing substantially to the ongoing epidemic of type 2 diabetes. Abdominal adiposity, a feature of…”
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Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study by Van Gaal, Luc F, Rissanen, Aila M, Scheen, André J, Ziegler, Olivier, Rössner, Stephan

“…In animal models, cannabinoid-1 receptor (CB 1) blockade produces a lean phenotype, with resistance to diet-induced obesity and associated dyslipidaemia. We…”
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Effect of Sibutramine on Cardiovascular Outcomes in Overweight and Obese Subjects by James, W. Philip T, Caterson, Ian D, Coutinho, Walmir, Finer, Nick, Van Gaal, Luc F, Maggioni, Aldo P, Torp-Pedersen, Christian, Sharma, Arya M, Shepherd, Gillian M, Rode, Richard A, Renz, Cheryl L

“…In this clinical trial, the appetite suppressant sibutramine as compared with placebo resulted in modest weight loss but also in an unexpected increase in the…”
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Not performing an OGTT results in significant underdiagnosis of (pre)diabetes in a high risk adult Caucasian population by Meijnikman, A S, De Block, C E M, Dirinck, E, Verrijken, A, Mertens, I, Corthouts, B, Van Gaal, L F

“…Objective: Type 2 diabetes (T2DM) is known to be underdiagnosed. Tests for diagnosis include fasting plasma glucose (FPG), oral glucose tolerance test (OGTT)…”
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Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function by Hectors, T. L. M., Vanparys, C., van der Ven, K., Martens, G. A., Jorens, P. G., Van Gaal, L. F., Covaci, A., De Coen, W., Blust, R.

“…The prevalence of diabetes mellitus is currently at epidemic proportions and it is estimated that it will increase even further over the next decades. Although…”
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NAFLD in type 1 diabetes: overrated or underappreciated? by Mertens, Jonathan, Van Gaal, Luc F., Francque, Sven M., De Block, Christophe

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries, affecting 25–30% of the general population and up to…”
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Obesity, haemostasis and the fibrinolytic system by Mertens, I., Gaal, L. F. Van

“…Summary Obese patients are at risk for the development of cardiovascular diseases, which can in part be explained by disturbances in the haemostatic and…”
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Therapeutic approaches for non-alcoholic steatohepatitis by Van Gaal, Luc F., Mertens, Jonathan, Francque, Sven, De Block, Christophe

“…Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have been reported as a novel worldwide epidemic, very often associated with…”
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Overweight, Obesity, and Blood Pressure: The Effects of Modest Weight Reduction by Mertens, Ilse L., Gaal, Luc F.

“…Several large epidemiological studies have shown an association between body mass index and blood pressure in normal weight and overweight patients. Weight…”
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CNV analysis and mutation screening indicate an important role for the NPY4R gene in human obesity by Aerts, Evi, Beckers, Sigri, Zegers, Doreen, Van Hoorenbeeck, Kim, Massa, Guy, Verrijken, An, Verhulst, Stijn L., Van Gaal, Luc F., Van Hul, Wim

“…Objective Genome‐wide copy number variation (CNV) analyses have associated the 10q11.22 CNV with obesity. As the NPY4R gene is the most interesting candidate…”
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Pivotal Role for the Visceral Fat Compartment in the Release of Persistent Organic Pollutants During Weight Loss by Dirinck, E, Dirtu, A. C, Jorens, P. G, Malarvannan, G, Covaci, A, Van Gaal, L. F

“…Context: Polychlorinated biphenyls (PCBs), are implicated as potential endocrine disruptors and obesogens. These lipophilic substances are preferentially…”
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Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes : A randomized trial by HEINE, Robert J, VAN GAAL, Luc F, JOHNS, Don, MIHM, Michael J, WIDEL, Mario H, BRODOWS, Robert G

“…Physicians may use either insulin or exenatide injections for patients with type 2 diabetes mellitus who have poor glycemic control despite taking oral blood…”
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Effect of sibutramine on weight maintenance after weight loss: a randomised trial by James, W Philip T, Astrup, Arne, Finer, Nick, Hilsted, Jannik, Kopelman, Peter, Rössner, Stephan, Saris, Wim H.M., Gaal, Luc F Van

“…Sibutramine is a tertiary amine that has been shown to induce dose-dependent weight loss and to enhance the effects of a low-calorie diet for up to a year. We…”
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Human leptin: from an adipocyte hormone to an endocrine mediator by Wauters, M, Considine, RV, Van Gaal, LF

“…Leptin is a mainly adipocyte-secreted protein that was discovered 5 years ago. Most of the research following this discovery focused on the role of leptin in…”
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Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome by Mertens, I, Verrijken, A, Michiels, J.J, Planken, M. van der, Ruige, J.B, Gaal, L.F. van

“…Objective: To investigate whether leukocyte count, fibrinogen, von Willebrand factor (vWF) and plasminogen activator inhibitor-1 activity (PAI-1) are increased…”
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Insulin resistance and environmental pollutants: experimental evidence and future perspectives by Hectors, Tine L M, Vanparys, Caroline, Van Gaal, Luc F, Jorens, Philippe G, Covaci, Adrian, Blust, Ronny

“…The metabolic disruptor hypothesis postulates that environmental pollutants may be risk factors for metabolic diseases. Because insulin resistance is involved…”
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Weight Loss and Sleep-Disordered Breathing in Childhood Obesity: Effects on Inflammation and Uric Acid by Hoorenbeeck, Kim, Franckx, Hilde, Debode, Patrick, Aerts, Petra, Wouters, Kristien, Ramet, Jose, Gaal, Luc F., Desager, Kristine N., Backer, Wilfried A., Verhulst, Stijn L.

“…Sleep‐disordered breathing (SDB) is prevalent in childhood obesity. It may be an independent risk factor for the metabolic syndrome. Possible mechanisms are…”
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Prevalence, risk factors and diagnostic accuracy of non-invasive tests for NAFLD in people with type 1 diabetes by Mertens, Jonathan, Weyler, Jonas, Dirinck, Eveline, Vonghia, Luisa, Kwanten, Wilhelmus J., Mortelmans, Laura, Peleman, Cedric, Chotkoe, Shivani, Spinhoven, Maarten, Vanhevel, Floris, Van Gaal, Luc F., De Winter, Benedicte Y., De Block, Christophe E.M., Francque, Sven M.

“…The epidemiology of non-alcoholic fatty liver disease (NAFLD) in people with type 1 diabetes (T1D) is not yet elucidated. This study aimed to assess the…”
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Mutation screen of the SIM1 gene in pediatric patients with early-onset obesity by Zegers, D, Beckers, S, Hendrickx, R, Van Camp, J K, de Craemer, V, Verrijken, A, Van Hoorenbeeck, K, Verhulst, S L, Rooman, R P, Desager, K N, Massa, G, Van Gaal, L F, Van Hul, W

“…Background: The transcription factor SIM1 (Single-minded 1) is involved in the control of food intake and in the pathogenesis of obesity. In mice, Sim1 is…”
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