Potential for transmission of naturally mutated H10N1 avian influenza virus to mammalian hosts and causing severe pulmonary disease

Subtype H10 avian influenza viruses (AIV) are distributed worldwide in wild aquatic birds, and can infect humans and several other mammalian species. In the present study, we investigated the naturally mutated PB2 gene in A/aquatic bird/South Korea/SW1/2018 (A/SW1/18, H10N1), isolated from wild bird...

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Bibliographic Details
Published in:	Frontiers in microbiology Vol. 14; p. 1256090
Main Authors:	Zanin, Mark, Le, Tran Bac, Kang, Jung-Ah, Kwon, Hyung-Jun, Hwang, Jaehyun, Ga, Eul Hae, Wong, Sook-San, Cho, Hae-Jin, Song, Daesub, Kim, Hye Kwon, Jeong, Dae Gwin, Yoon, Sun-Woo
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 12-09-2023
Subjects:	avian influenza ferret model H10N1 Microbiology transmission wild bird zoonosis
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Summary:	Subtype H10 avian influenza viruses (AIV) are distributed worldwide in wild aquatic birds, and can infect humans and several other mammalian species. In the present study, we investigated the naturally mutated PB2 gene in A/aquatic bird/South Korea/SW1/2018 (A/SW1/18, H10N1), isolated from wild birds during the 2018–2019 winter season. This virus was originally found in South Korea, and is similar to isolates from mainland China and Mongolia. It had low pathogenicity, lacked a multi-basic cleavage site, and showed a binding preference for α2,3-linked sialic acids. However, it can infect mice, causing severe disease and lung pathology. SW1 was also transmitted by direct contact in ferrets, and replicated in the respiratory tract tissue, with no evidence of extrapulmonary spread. The pathogenicity and transmissibility of SW1 in mouse and ferret models were similar to those of the pandemic strain A/California/04/2009 (A/CA/04, H1N1). These factors suggest that subtype H10 AIVs have zoonotic potential and may transmit from human to human, thereby posing a potential threat to public health. Therefore, the study highlights the urgent need for closer monitoring of subtype H10 AIVs through continued surveillance of wild aquatic birds.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Sujuan Chen, Yangzhou University, China; Huapeng Feng, Zhejiang Sci-Tech University, China These authors have contributed equally to this work and share first authorship Edited by: Jiahao Zhang, Huazhong Agricultural University, China
ISSN:	1664-302X 1664-302X
DOI:	10.3389/fmicb.2023.1256090