Search Results - "GYLLING, Helena"

Phytosterols, Phytostanols, and Lipoprotein Metabolism by Gylling, Helena, Simonen, Piia

“…The efficacy of phytosterols and phytostanols added to foods and food supplements to obtain significant non-pharmacologic serum and low density lipoprotein…”
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Clinical utility of serum markers of cholesterol absorption and synthesis by Gylling, Helena

“…The serum noncholesterol sterols are widely used today in clinical lipid research as surrogate markers of cholesterol absorption and synthesis. Their…”
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Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars by Luukkonen, Panu K, Sädevirta, Sanja, Zhou, You, Kayser, Brandon, Ali, Ashfaq, Ahonen, Linda, Lallukka, Susanna, Pelloux, Véronique, Gaggini, Melania, Jian, Ching, Hakkarainen, Antti, Lundbom, Nina, Gylling, Helena, Salonen, Anne, Orešič, Matej, Hyötyläinen, Tuulia, Orho-Melander, Marju, Rissanen, Aila, Gastaldelli, Amalia, Clément, Karine, Hodson, Leanne, Yki-Järvinen, Hannele

“…Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose…”
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Cholesterol metabolism in cholestatic liver disease and liver transplantation:From molecular mechanisms to clinical implications by Nemes, Katriina, Åberg, Fredrik, Gylling, Helena, Isoniemi, Helena

“…The aim of this review is to enlighten the critical roles that the liver plays in cholesterol metabolism. Liver transplantation can serve as gene therapy or a…”
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Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease by Gylling, Helena, Plat, Jogchum, Turley, Stephen, Ginsberg, Henry N, Ellegård, Lars, Jessup, Wendy, Jones, Peter J, Lütjohann, Dieter, Maerz, Winfried, Masana, Luis, Silbernagel, Günther, Staels, Bart, Borén, Jan, Catapano, Alberico L, De Backer, Guy, Deanfield, John, Descamps, Olivier S, Kovanen, Petri T, Riccardi, Gabriele, Tokgözoglu, Lale, Chapman, M. John

“…Abstract Objective This EAS Consensus Panel critically appraised evidence relevant to the benefit to risk relationship of functional foods with added plant…”
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Vegan diet in young children remodels metabolism and challenges the statuses of essential nutrients by Hovinen, Topi, Korkalo, Liisa, Freese, Riitta, Skaffari, Essi, Isohanni, Pirjo, Niemi, Mikko, Nevalainen, Jaakko, Gylling, Helena, Zamboni, Nicola, Erkkola, Maijaliisa, Suomalainen, Anu

“…Vegan diets are gaining popularity, also in families with young children. However, the effects of strict plant‐based diets on metabolism and micronutrient…”
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Methodological Aspects of Phytosterol Measurements in Biological Samples by Gylling, Helena, Simonen, Piia, Kaipiainen, Leena, Wester, Ingmar

“…Phytosterol measurement has gained a lot of interest during the last two decades after foods and supplements with added 4-desmethyl phytosterols were…”
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Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis by Rahtu-Korpela, Lea, Määttä, Jenni, Dimova, Elitsa Y, Hörkkö, Sohvi, Gylling, Helena, Walkinshaw, Gail, Hakkola, Jukka, Kivirikko, Kari I, Myllyharju, Johanna, Serpi, Raisa, Koivunen, Peppi

“…OBJECTIVE—Small-molecule hypoxia-inducible factor prolyl 4-hydroxylase (HIF-P4H) inhibitors are being explored in clinical studies for the treatment of anemia…”
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Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans by Sevastianova, Ksenia, Santos, Alexandre, Kotronen, Anna, Hakkarainen, Antti, Makkonen, Janne, Silander, Kaisa, Peltonen, Markku, Romeo, Stefano, Lundbom, Jesper, Lundbom, Nina, Olkkonen, Vesa M, Gylling, Helena, Fielding, Barbara A, Rissanen, Aila, Yki-Järvinen, Hannele

“…Background: Cross-sectional studies have identified a high intake of simple sugars as an important dietary factor predicting nonalcoholic fatty liver disease…”
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Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane by Björkgren, Ida, Gylling, Helena, Turunen, Heikki, Huhtaniemi, Ilpo, Strauss, Leena, Poutanen, Matti, Sipilä, Petra

“…ABSTRACT During epididymal sperm maturation, the lipid content of the sperm membrane is modified, which facilitates sperm motility and fertility. However,…”
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Author Correction: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis by Scholz, Markus, Horn, Katrin, Pott, Janne, Gross, Arnd, Kleber, Marcus E., Delgado, Graciela E., Mishra, Pashupati Prasad, Kirsten, Holger, Gieger, Christian, Müller-Nurasyid, Martina, Tönjes, Anke, Kovacs, Peter, Lehtimäki, Terho, Raitakari, Olli, Kähönen, Mika, Gylling, Helena, Baber, Ronny, Isermann, Berend, Stumvoll, Michael, Loeffler, Markus, März, Winfried, Meitinger, Thomas, Peters, Annette, Thiery, Joachim, Teupser, Daniel, Ceglarek, Uta

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Dose-dependent LDL-cholesterol lowering effect by plant stanol ester consumption: clinical evidence by Laitinen, Kirsi, Gylling, Helena

“…Elevated serum lipids are linked to cardiovascular diseases calling for effective therapeutic means to reduce particularly LDL-cholesterol (LDL-C) levels…”
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HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD by Laitakari, Anna, Tapio, Joona, Mäkelä, Kari A., Herzig, Karl-Heinz, Dengler, Franziska, Gylling, Helena, Walkinshaw, Gail, Myllyharju, Johanna, Dimova, Elitsa Y., Serpi, Raisa, Koivunen, Peppi

“…Non-alcoholic fatty liver disease (NAFLD) parallels the global obesity epidemic with unmet therapeutic needs. We investigated whether inhibition of…”
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Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis by Scholz, Markus, Horn, Katrin, Pott, Janne, Gross, Arnd, Kleber, Marcus E., Delgado, Graciela E., Mishra, Pashupati Prasad, Kirsten, Holger, Gieger, Christian, Müller-Nurasyid, Martina, Tönjes, Anke, Kovacs, Peter, Lehtimäki, Terho, Raitakari, Olli, Kähönen, Mika, Gylling, Helena, Baber, Ronny, Isermann, Berend, Stumvoll, Michael, Loeffler, Markus, März, Winfried, Meitinger, Thomas, Peters, Annette, Thiery, Joachim, Teupser, Daniel, Ceglarek, Uta

“…Phytosterol serum concentrations are under tight genetic control. The relationship between phytosterols and coronary artery disease (CAD) is controversially…”
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Lowering Low-Density Lipoprotein Cholesterol Concentration with Plant Stanol Esters to Reduce the Risk of Atherosclerotic Cardiovascular Disease Events at a Population Level: A Critical Discussion by Gylling, Helena, Strandberg, Timo E, Kovanen, Petri T, Simonen, Piia

“…Atherosclerotic cardiovascular diseases (ASCVDs) cause every fifth death worldwide. However, it is possible to prevent the progression of ASCVDs by reducing…”
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Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity by Simonen, Piia, Kotronen, Anna, Hallikainen, Maarit, Sevastianova, Ksenia, Makkonen, Janne, Hakkarainen, Antti, Lundbom, Nina, Miettinen, Tatu A, Gylling, Helena, Yki-Järvinen, Hannele

“…Background & Aims Non-alcoholic fatty liver disease (NAFLD) is associated with impaired glucose and lipoprotein metabolism. However, the metabolism of…”
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Heart-healthy diets including phytostanol ester consumption to reduce the risk of atherosclerotic cardiovascular diseases. A clinical review by Simonen, Piia, Nylund, Lotta, Vartiainen, Erkki, Kovanen, Petri T, Strandberg, Timo E, Öörni, Katariina, Wester, Ingmar, Gylling, Helena

“…The risk of atherosclerotic cardiovascular diseases (ASCVDs) can be reduced by lowering low-density lipoprotein cholesterol (LDL-C) concentrations…”
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Lipoprotein subclass metabolism in nonalcoholic steatohepatitis[S] by Männistö, Ville T., Simonen, Marko, Soininen, Pasi, Tiainen, Mika, Kangas, Antti J., Kaminska, Dorota, Venesmaa, Sari, Käkelä, Pirjo, Kärjä, Vesa, Gylling, Helena, Ala-Korpela, Mika, Pihlajamäki, Jussi

“…Nonalcoholic steatohepatitis (NASH) is associated with increased synthesis of triglycerides and cholesterol coupled with increased VLDL synthesis in the liver…”
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Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet) by Lankinen, Maria, Kolehmainen, Marjukka, Jääskeläinen, Tiina, Paananen, Jussi, Joukamo, Laura, Kangas, Antti J, Soininen, Pasi, Poutanen, Kaisa, Mykkänen, Hannu, Gylling, Helena, Orešič, Matej, Jauhiainen, Matti, Ala-Korpela, Mika, Uusitupa, Matti, Schwab, Ursula

“…We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the…”
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The validity of serum squalene and non-cholesterol sterols as surrogate markers of cholesterol synthesis and absorption in type 2 diabetes by Simonen, Piia, Gylling, Helena, Miettinen, Tatu A

“…Abstract Objective Serum non-cholesterol sterol ratios to cholesterol reflect cholesterol metabolism in non-diabetes populations. In type 2 diabetes (T2D)…”
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