Search Results - "GUZHOVA, IRINA V"
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1
The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence
Published in Biochimica et biophysica acta. Reviews on cancer (01-07-2024)“…Tumor recurrence is a mechanism triggered in sparse populations of cancer cells that usually remain in a quiescent state after strict stress and/or therapeutic…”
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2
Glyceraldehyde-3-phosphate Dehydrogenase is a Multifaceted Therapeutic Target
Published in Pharmaceutics (02-05-2020)“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme whose role in cell metabolism and homeostasis is well defined, while its function in…”
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3
Hsp70 Negatively Regulates Autophagy via Governing AMPK Activation, and Dual Hsp70-Autophagy Inhibition Induces Synergetic Cell Death in NSCLC Cells
Published in International journal of molecular sciences (22-08-2024)“…Proteostasis mechanisms, such as proteotoxic-stress response and autophagy, are increasingly recognized for their roles in influencing various cancer hallmarks…”
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4
Hsp70-containing extracellular vesicles are capable of activating of adaptive immunity in models of mouse melanoma and colon carcinoma
Published in Scientific reports (29-10-2021)“…The release of Hsp70 chaperone from tumor cells is found to trigger the full-scale anti-cancer immune response. Such release and the proper immune reaction can…”
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5
New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease
Published in Experimental neurology (01-08-2018)“…Molecular chaperone HSP70 (HSPA1A) has therapeutic potential in conformational neurological diseases. Here we evaluate the neuroprotective function of the…”
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6
Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress
Published in International journal of molecular sciences (03-02-2021)“…Hypoxia, which commonly accompanies tumor growth, depending on its strength may cause the enhancement of tumorigenicity of cancer cells or their death. One of…”
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Indolylazine Derivative Induces Chaperone Expression in Aged Neural Cells and Prevents the Progression of Alzheimer's Disease
Published in Molecules (Basel, Switzerland) (15-12-2022)“…The risk of progression of most sporadic neurodegenerative diseases, including Alzheimer's disease, increases with age. Traditionally, this is associated with…”
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Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone
Published in International journal of molecular sciences (01-07-2021)“…Hyperglycemia may contribute to the progression of carcinomas by triggering epithelial-to-mesenchymal transition (EMT). Some proteostasis systems are involved…”
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9
Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH
Published in Biochemical and biophysical research communications (12-02-2016)“…The Hsp70 chaperone is known to elicit cytoprotective activity and this protection has a negative impact in anti-tumor therapy. In cancer cells subjected to…”
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10
Protein Interactome of Amyloid-β as a Therapeutic Target
Published in Pharmaceuticals (Basel, Switzerland) (01-02-2023)“…The amyloid concept of Alzheimer's disease (AD) assumes the β-amyloid peptide (Aβ) as the main pathogenic factor, which injures neural and other brain cells,…”
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11
Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex
Published in Journal of experimental & clinical cancer research (25-10-2023)“…Abstract Background Cancer recurrence is regulated by a variety of factors, among which is the material of dying tumor cells; it is suggested that remaining…”
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12
Anthraquinone Derivatives and Other Aromatic Compounds from Marine Fungus Asteromyces cruciatus KMM 4696 and Their Effects against Staphylococcus aureus
Published in Marine drugs (29-07-2023)“…New anthraquinone derivatives acruciquinones A–C (1–3), together with ten known metabolites, were isolated from the obligate marine fungus Asteromyces…”
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The Effects of Marine Fungal Asterripeptides A-C on In Vitro and In Vivo Staphylococcus aureus Skin Infection
Published in Pharmaceuticals (Basel, Switzerland) (08-10-2024)“…This study aimed to investigate the in vitro and in vivo antibacterial and cytoprotective activities of marine fungal tripeptide derivatives with cinnamic acid…”
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14
Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage
Published in Marine drugs (29-09-2021)“…Cerebrosides are glycosylated sphingolipids, and in mammals they contribute to the pro-/anti-inflammatory properties and innate antimicrobial activity of the…”
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15
Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti‐cancer drugs
Published in FEBS letters (01-12-2017)“…Most Hsp70 chaperone inhibitors exert anti‐cancer effects; however, their high cytotoxicity proposed the use of peptide fragments of the chaperone as safer…”
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Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3
Published in International journal of molecular sciences (25-08-2018)“…The Hsp70 chaperone binds and inhibits proteins implicated in apoptotic signaling including Caspase-3. Induction of apoptosis is an important mechanism of…”
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17
Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates
Published in Frontiers in neuroscience (16-05-2017)“…The vast majority of neurodegenerative pathologies stem from the formation of toxic oligomers and aggregates composed of wrongly folded proteins. These protein…”
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The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy
Published in Membranes (Basel) (07-11-2021)“…Currently, the success of targeted anticancer therapies largely depends on the correct understanding of the dormant state of cancer cells, since it is…”
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GAPDH binders as potential drugs for the therapy of polyglutamine diseases: Design of a new screening assay
Published in FEBS letters (27-02-2015)“…•A new assay for screening anti-aggregation drugs was designed.•The new assay better imitates real conditions of the aggregation process in HD pathogenic…”
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Combined Cytotoxic Effect of Inhibitors of Proteostasis on Human Colon Cancer Cells
Published in Pharmaceuticals (Basel, Switzerland) (25-07-2022)“…Despite significant progress in the diagnosis and treatment of colorectal cancer, drug resistance continues to be a major limitation of therapy. In this…”
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