Search Results - "GUZHOVA, IRINA V"

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  1. 1

    The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence by Alhasan, Bashar A., Morozov, Alexey V., Guzhova, Irina V., Margulis, Boris A.

    “…Tumor recurrence is a mechanism triggered in sparse populations of cancer cells that usually remain in a quiescent state after strict stress and/or therapeutic…”
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    Glyceraldehyde-3-phosphate Dehydrogenase is a Multifaceted Therapeutic Target by Lazarev, Vladimir F, Guzhova, Irina V, Margulis, Boris A

    Published in Pharmaceutics (02-05-2020)
    “…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme whose role in cell metabolism and homeostasis is well defined, while its function in…”
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    Hsp70 Negatively Regulates Autophagy via Governing AMPK Activation, and Dual Hsp70-Autophagy Inhibition Induces Synergetic Cell Death in NSCLC Cells by Alhasan, Bashar, Gladova, Yana A, Sverchinsky, Dmitry V, Aksenov, Nikolai D, Margulis, Boris A, Guzhova, Irina V

    “…Proteostasis mechanisms, such as proteotoxic-stress response and autophagy, are increasingly recognized for their roles in influencing various cancer hallmarks…”
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    New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease by Ekimova, Irina V., Plaksina, Daria V., Pastukhov, Yuri F., Lapshina, Ksenia V., Lazarev, Vladimir F., Mikhaylova, Elena R., Polonik, Sergey G., Pani, Bibhusita, Margulis, Boris A., Guzhova, Irina V., Nudler, Evgeny

    Published in Experimental neurology (01-08-2018)
    “…Molecular chaperone HSP70 (HSPA1A) has therapeutic potential in conformational neurological diseases. Here we evaluate the neuroprotective function of the…”
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    Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress by Mikeladze, Marina A, Dutysheva, Elizaveta A, Kartsev, Victor G, Margulis, Boris A, Guzhova, Irina V, Lazarev, Vladimir F

    “…Hypoxia, which commonly accompanies tumor growth, depending on its strength may cause the enhancement of tumorigenicity of cancer cells or their death. One of…”
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    Indolylazine Derivative Induces Chaperone Expression in Aged Neural Cells and Prevents the Progression of Alzheimer's Disease by Lazarev, Vladimir F, Dutysheva, Elizaveta A, Mikhaylova, Elena R, Trestsova, Maria A, Utepova, Irina A, Chupakhin, Oleg N, Margulis, Boris A, Guzhova, Irina V

    Published in Molecules (Basel, Switzerland) (15-12-2022)
    “…The risk of progression of most sporadic neurodegenerative diseases, including Alzheimer's disease, increases with age. Traditionally, this is associated with…”
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    Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone by Nikotina, Alina D., Vladimirova, Snezhana A., Komarova, Elena Y., Alexeev, Dmitry, Efremov, Sergey, Leonova, Elizaveta, Pavlov, Rostislav, Kartsev, Viktor G., Polonik, Sergey G., Margulis, Boris A., Guzhova, Irina V.

    “…Hyperglycemia may contribute to the progression of carcinomas by triggering epithelial-to-mesenchymal transition (EMT). Some proteostasis systems are involved…”
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    Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH by Lazarev, Vladimir F., Nikotina, Alina D., Mikhaylova, Elena R., Nudler, Evgeny, Polonik, Sergey G., Guzhova, Irina V., Margulis, Boris A.

    “…The Hsp70 chaperone is known to elicit cytoprotective activity and this protection has a negative impact in anti-tumor therapy. In cancer cells subjected to…”
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  10. 10

    Protein Interactome of Amyloid-β as a Therapeutic Target by Lazarev, Vladimir F, Dutysheva, Elizaveta A, Kanunikov, Igor E, Guzhova, Irina V, Margulis, Boris A

    Published in Pharmaceuticals (Basel, Switzerland) (01-02-2023)
    “…The amyloid concept of Alzheimer's disease (AD) assumes the β-amyloid peptide (Aβ) as the main pathogenic factor, which injures neural and other brain cells,…”
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    Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage by Chingizova, Ekaterina A, Menchinskaya, Ekaterina S, Chingizov, Artur R, Pislyagin, Evgeny A, Girich, Elena V, Yurchenko, Anton N, Guzhova, Irina V, Mikhailov, Valery V, Aminin, Dmitry L, Yurchenko, Ekaterina A

    Published in Marine drugs (29-09-2021)
    “…Cerebrosides are glycosylated sphingolipids, and in mammals they contribute to the pro-/anti-inflammatory properties and innate antimicrobial activity of the…”
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    Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti‐cancer drugs by Sverchinsky, Dmitry V., Lazarev, Vladimir F., Semenyuk, Pavel I., Mitkevich, Vladimir A., Guzhova, Irina V., Margulis, Boris A.

    Published in FEBS letters (01-12-2017)
    “…Most Hsp70 chaperone inhibitors exert anti‐cancer effects; however, their high cytotoxicity proposed the use of peptide fragments of the chaperone as safer…”
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    Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates by Lazarev, Vladimir F, Mikhaylova, Elena R, Guzhova, Irina V, Margulis, Boris A

    Published in Frontiers in neuroscience (16-05-2017)
    “…The vast majority of neurodegenerative pathologies stem from the formation of toxic oligomers and aggregates composed of wrongly folded proteins. These protein…”
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    The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy by Alhasan, Bashar A, Gordeev, Sergei A, Knyazeva, Aleksandra R, Aleksandrova, Kseniia V, Margulis, Boris A, Guzhova, Irina V, Suvorova, Irina I

    Published in Membranes (Basel) (07-11-2021)
    “…Currently, the success of targeted anticancer therapies largely depends on the correct understanding of the dormant state of cancer cells, since it is…”
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    GAPDH binders as potential drugs for the therapy of polyglutamine diseases: Design of a new screening assay by Lazarev, Vladimir F., Benken, Konstantin A., Semenyuk, Pavel I., Sarantseva, Svetlana V., Bolshakova, Olga I., Mikhaylova, Elena R., Muronetz, Vladimir I., Guzhova, Irina V., Margulis, Boris A.

    Published in FEBS letters (27-02-2015)
    “…•A new assay for screening anti-aggregation drugs was designed.•The new assay better imitates real conditions of the aggregation process in HD pathogenic…”
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    Combined Cytotoxic Effect of Inhibitors of Proteostasis on Human Colon Cancer Cells by Nikotina, Alina D, Vladimirova, Snezhana A, Kokoreva, Nadezhda E, Komarova, Elena Y, Aksenov, Nikolay D, Efremov, Sergey, Leonova, Elizaveta, Pavlov, Rostislav, Kartsev, Viktor G, Zhang, Zhichao, Margulis, Boris A, Guzhova, Irina V

    Published in Pharmaceuticals (Basel, Switzerland) (25-07-2022)
    “…Despite significant progress in the diagnosis and treatment of colorectal cancer, drug resistance continues to be a major limitation of therapy. In this…”
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