Search Results - "GUTMAN, G. A"

Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia by TOMITA, H, SHAKKOTTAI, V. G, GUTMAN, G. A, SUN, G, BUNNEY, W. E, CAHALAN, M. D, CHANDY, K. G, GARGUS, J. J

“…The small-conductance calcium-activated K(+) channel SK3 (SKCa3/KCNN3) regulates electrical excitability and neurotransmitter release in monoaminergic neurons,…”
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Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat : a candidate for schizophrenia and bipolar disorder? by CHANDY, K. G, FANTINO, E, MORRIS-ROSENDAHL, D. J, GARGUS, J. J, WITTEKINDT, O, KALMAN, K, TONG, L.-L, HO, T.-H, GUTMAN, G. A, CROCQ, M.-A, GANGULI, R, NIMGAONKAR, V

“…Many human hereditary neurodegenerative diseases are caused by expanded CAG repeats, and anonymous CAG expansions have also been described in schizophrenia and…”
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Slipped-strand mispairing: a major mechanism for DNA sequence evolution by LEVINSON, G, GUTMAN, G. A

“…Simple repetitive DNA sequences are a widespread and abundant feature of genomic DNA. The following several features characterize such sequences: (1) they…”
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hKCa3/KCNN3 potassium channel gene : association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21 by DROR, V, SHAMIR, E, KALMAN, K, JONES, E. G, CHANDY, K. G, GARGUS, J. J, GUTMAN, G. A, NAVON, R, GHANSHANI, S, KIMHI, R, SWARTZ, M, BARAK, Y, WEIZMAN, R, AVIVI, L, LITMANOVITCH, T, FANTINO, E

“…We demonstrate a significant association between longer CAG repeats in the hKCa3/KCNN3 calcium-activated potassium channel gene and schizophrenia in Israeli…”
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Nonrandom Utilization of Codon Pairs in Escherichia coli by Gutman, George A., Hatfield, G. Wesley

“…We have analyzed protein-coding sequences of Escherichia coli and find that codon-pair utilization is highly biased, reflecting overrepresentation or…”
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Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia by BOWEN, T, GUY, C. A, MCCARTHY, G, CHANDY, K. G, FANTINO, E, KALMAN, K, GUTMAN, G. A, GARGUS, J. J, WILLIAMS, J, MCGUFFIN, P, OWEN, M. J, O'DONOVAN, M. C, CRADDOCK, N, CARDNO, A. G, WILLIAMS, N. M, SPURLOCK, G, MURPHY, K. C, JONES, L. A, GRAY, M, SANDERS, R. D

“…A recent study has suggested that a polymorphism in the hKCa3 potassium channel may be associated with raised susceptibility to schizophrenia. Despite its…”
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Expression and Chromosomal Localization of a Lymphocyte K+Channel Gene by Grissmer, Stephan, Dethlefs, Brent, Wasmuth, John J., Goldin, Alan L., Gutman, George A., Cahalan, Michael D., Chandy, K. George

“…We recently isolated a family of three closely related mouse K+channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons…”
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High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12 by LEVINSON, G, GUTMAN, G. A

“…Slipped-strand mispairing (SSM) may play an major role in repetitive DNA sequence evolution by generating large numbers of short frameshift mutations within…”
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Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability by STRONG, M, CHANDY, K. G, GUTMAN, G. A

“…We have analyzed nucleic acid and amino acid sequence alignments of a variety of voltage-sensitive ion channels, using several methods for phylogenetic tree…”
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Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation by Nguyen, A, Kath, J C, Hanson, D C, Biggers, M S, Canniff, P C, Donovan, C B, Mather, R J, Bruns, M J, Rauer, H, Aiyar, J, Lepple-Wienhues, A, Gutman, G A, Grissmer, S, Cahalan, M D, Chandy, K G

“…The nonpeptide agent CP-339,818 (1-benzyl-4-pentylimino-1,4-dihydroquinoline) and two analogs (CP-393,223 and CP-394,322) that differ only with respect to the…”
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UK‐78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage‐gated potassium channel and inhibits human T cell activation by Hanson, Douglas C, Nguyen, Angela, Mather, Robert J, Rauer, Heiko, Koch, Kevin, Burgess, Laurence E, Rizzi, James P, Donovan, Carol B, Bruns, Matthew J, Canniff, Paul C, Cunningham, Ann C, Verdries, Kimberly A, Mena, Edward, Kath, John C, Gutman, George A, Cahalan, Michael D, Grissmer, Stephan, Chandy, K George

“…UK‐78,282, a novel piperidine blocker of the T lymphocyte voltage‐gated K+ channel, Kv1.3, was discovered by screening a large compound file using a…”
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Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences by Ghanshani, S, Wulff, H, Miller, M J, Rohm, H, Neben, A, Gutman, G A, Cahalan, M D, Chandy, K G

“…We used whole cell recording to evaluate functional expression of the intermediate conductance Ca(2+)-activated K(+) channel, IKCa1, in response to various…”
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Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines by Grissmer, S, Nguyen, A N, Aiyar, J, Hanson, D C, Mather, R J, Gutman, G A, Karmilowicz, M J, Auperin, D D, Chandy, K G

“…We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in…”
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A unified nomenclature for short-chain peptides isolated from scorpion venoms: α-KTx molecular subfamilies by Tytgat, Jan, Chandy, K.George, Garcia, Maria L, Gutman, George A, Martin-Eauclaire, Marie-France, van der Walt, Jurg J, Possani, Lourival D

“…Peptidyl toxins are used extensively to determine the pharmacology of ion channels. Four families of peptides have been purified from scorpion venom. In this…”
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A Family of Three Mouse Potassium Channel Genes with Intronless Coding Regions by Chandy, K. George, Williams, Calvin B., Spencer, Robert H., Aguilar, Barbara A., Ghanshani, Sanjiv, Tempel, Bruce L., Gutman, George A.

“…To understand the molecular mechanisms responsible for generating physiologically diverse potassium channels in mammalian cells, mouse genomic clones have been…”
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Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia by GHANSHANI, S, COLEMAN, M, GUSTAVSSON, P, WU, A. C.-L, GARGUS, J. J, GUTMAN, G. A, DAHL, N, MOHRENWEISER, H, CHANDY, K. G

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The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells by Grissmer, S, Ghanshani, S, Dethlefs, B, McPherson, J D, Wasmuth, J J, Gutman, G A, Cahalan, M D, Chandy, K G

“…T lymphocytes exhibit three distinct types of voltage-gated K+ channels, n, n', and l, that are distributed in the T cell lineage according to subset, as well…”
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Delineation of the Clotrimazole/TRAM-34 Binding Site on the Intermediate Conductance Calcium-activated Potassium Channel, IKCa1 by Wulff, H, Gutman, G A, Cahalan, M D, Chandy, K G

“…Selective and potent triarylmethane blockers of the intermediate conductance calcium-activated potassium channel, IKCa1, have therapeutic use in sickle cell…”
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T cell receptor beta-chain genes in the rat. Availability and pattern of utilization of V gene segments differs from that in the mouse by Williams, CB, Gutman, GA

“…We have constructed a specifically primed thymus cDNA library to study the V-region repertoire of the TCR beta-chain in the laboratory rat. From this library,…”
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A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T Lymphocytes by Beeton, Christine, Wulff, Heike, Singh, Satendra, Botsko, Steve, Crossley, George, Gutman, George A, Cahalan, Michael D, Pennington, Michael, Chandy, K George

“…T lymphocytes with unusually high expression of the voltage-gated Kv1.3 channel (Kv1.3 high cells) have been implicated in the pathogenesis of experimental…”
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