Search Results - "GUTKIND, J. S"

Human tumor-associated viruses and new insights into the molecular mechanisms of cancer by Martin, D, Gutkind, J S

“…The study of acute-transforming retroviruses and their oncogenes and of the multiple mechanisms deployed by DNA viruses to circumvent the growth-suppressive…”
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Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis by Knox, S.M, Lombaert, I.M.A, Reed, X, Vitale-Cross, L, Gutkind, J.S, Hoffman, M.P

“…The maintenance of a progenitor cell population as a reservoir of undifferentiated cells is required for organ development and regeneration. However, the…”
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MAP kinases and the control of nuclear events by Turjanski, A G, Vaqué, J P, Gutkind, J S

“…The mitogen-activated protein kinases (MAPKs) are a family of serine/threonine kinases that play an essential role in signal transduction by modulating gene…”
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An NF-κB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia by Martin, D, Galisteo, R, Ji, Y, Montaner, S, Gutkind, J S

“…Kaposi's sarcoma (KS) is the most frequent AIDS-associated malignancy, etiologically linked to the infection with the human herpesvirus 8 (HHV-8/KSHV). This…”
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TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation by Sun, C, Dobi, A, Mohamed, A, Li, H, Thangapazham, R L, Furusato, B, Shaheduzzaman, S, Tan, S-H, Vaidyanathan, G, Whitman, E, Hawksworth, D J, Chen, Y, Nau, M, Patel, V, Vahey, M, Gutkind, J S, Sreenath, T, Petrovics, G, Sesterhenn, I A, McLeod, D G, Srivastava, S

“…The high prevalence of TMPRSS2-ERG rearrangements (∼60%) in prostate cancer (CaP) leads to androgenic induction of the ETS -related gene ( ERG ) expression…”
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Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing by Castilho, RM, Squarize, CH, Gutkind, JS

“…The molecular circuitries controlling the process of skin wound healing have gained new significant insights in recent years. This knowledge is built on…”
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Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells by O'Hayre, M, Inoue, A, Kufareva, I, Wang, Z, Mikelis, C M, Drummond, R A, Avino, S, Finkel, K, Kalim, K W, DiPasquale, G, Guo, F, Aoki, J, Zheng, Y, Lionakis, M S, Molinolo, A A, Gutkind, J S

“…G proteins and their cognate G protein-coupled receptors (GPCRs) function as critical signal transduction molecules that regulate cell survival, proliferation,…”
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c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase by Szabo, R, Rasmussen, A L, Moyer, A B, Kosa, P, Schafer, J M, Molinolo, A A, Gutkind, J S, Bugge, T H

“…The progression and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene. The underlying…”
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Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis by Sales, K U, Friis, S, Konkel, J E, Godiksen, S, Hatakeyama, M, Hansen, K K, Rogatto, S R, Szabo, R, Vogel, L K, Chen, W, Gutkind, J S, Bugge, T H

“…The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with…”
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Role of GRB2‐associated binder 1 in epidermal growth factor receptor‐induced signaling in head and neck squamous cell carcinoma by Hoeben, A., Martin, D., Clement, P.M., Cools, J., Gutkind, J.S.

“…The epidermal growth factor receptor (EGFR) plays an important role in the pathogenesis of head and neck squamous cell carcinoma (HNSCC). Despite the high…”
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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate by Cuvillier, Olivier, Pirianov, Grisha, Kleuser, Burkhard, Vanek, Philip G, Coso, Omar A, Gutkind, J. Silvio, Spiegel, Sarah

“…Ceramide is an important regulatory participant of programmed cell death (apoptosis) induced by tumour-necrosis factor (TNF)-alpha and Fas ligand, members of…”
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The Kaposi's Sarcoma-associated Herpes Virus G Protein-coupled Receptor Up-Regulates Vascular Endothelial Growth Factor Expression and Secretion through Mitogen-activated Protein Kinase and p38 Pathways Acting on Hypoxia-inducible Factor 1 alpha by Sodhi, A, Montaner, S, Patel, V, Zohar, M, Bais, C, Mesri, E A, Gutkind, J S

“…The elucidation of the molecular mechanisms governing the transition from a nonangiogenic to an angiogenic phenotype is central for understanding and…”
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Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells by CASTILHO, R. M, SQUARIZE, C. H, PATEL, V, MILLAR, S. E, ZHENG, Y, MOLINOLO, A, GUTKIND, J. S

“…Epithelial stem cells in the bulge region within the hair follicle maintain the cyclic hair growth, but whether these stem cells also contribute to the…”
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Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor by Dwyer, J, Le Guelte, A, Galan Moya, E M, Sumbal, M, Carlotti, A, Douguet, L, Gutkind, J S, Grange, P A, Dupin, N, Gavard, J

“…Kaposi Sarcoma (KS) are opportunistic tumors, associated with human herpes virus 8 (HHV8) infection. KS development is highly favored by immune-depression and…”
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Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure by Cheong, S.C, Chandramouli, G.V.R, Saleh, A, Zain, R.B, Lau, S.H, Sivakumaren, S, Pathmanathan, R, Prime, S.S, Teo, S.H, Patel, V, Gutkind, J.S

“…Summary Oral squamous cell carcinoma (OSCC) is a world health problem and is associated with exposure to different risk factors. In the west, smoking and…”
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Cbl-b regulates the CD28 dependence of T-cell activation by Gu, Hua, Chiang, Yungping J, Kole, Hemanta K, Brown, Karen, Naramura, Mayumi, Fukuhara, Shigetomo, Hu, Ren-Ju, Jang, Ihn Kyung, Gutkind, J. Silvio, Shevach, Ethan

“…Whereas co-stimulation of the T-cell antigen receptor (TCR) and CD28 triggers T-cell activation, stimulation of the TCR alone may result in an anergic state or…”
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A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents by SANCHEZ-PRIETO, R, ROJAS, J. M, TAYA, Y, GUTKIND, J. S

“…The tumor suppressor p53 plays a central role in sensing damaged DNA and orchestrating the consequent cellular responses. However, how DNA damage leads to the…”
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Reciprocal negative regulation between S100A7 psoriasin and β-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity by Zhou, G, Xie, T-X, Zhao, M, Jasser, S A, Younes, M N, Sano, D, Lin, J, Kupferman, M E, Santillan, A A, Patel, V, Gutkind, J S, EI-Naggar, A K, Emberley, E D, Watson, P H, Matsuzawa, S-I, Reed, J C, Myers, J N

“…Overexpression of S100A7 (psoriasin), a small calcium-binding protein, has been associated with the development of psoriasis and carcinomas in different types…”
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Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ by Lopez-Llasaca, Marco, Crespo, Piero, Pellici, P. Giuseppe, Gutkind, J. Silvio, Wetzker, Reinhard

“…The tyrosine kinase class of receptors induces mitogen-activated protein kinase (MAPK) activation through the sequential interaction of the signaling proteins…”
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Head and Neck Cancer in the New Era of Precision Medicine by Nör, J.E., Gutkind, J.S.

“…New Precision Therapies For the past 4 decades, therapy for patients with head and neck cancer has been centered on surgery, platinum-based therapies, and…”
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