Search Results - "GUTHRIE, R"

New carbon dates link climatic change with human colonization and Pleistocene extinctions by Dale Guthrie, R

“…Drastic ecological restructuring, species redistribution and extinctions mark the Pleistocene–Holocene transition, but an insufficiency of numbers of…”
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Rapid body size decline in Alaskan Pleistocene horses before extinction by Dale Guthrie, R

“…About 70% of North American large mammal species were lost at the end of the Pleistocene epoch. The causes of this extinction-the role of humans versus that of…”
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MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate by Ireland, Abbie S., Micinski, Alexi M., Kastner, David W., Guo, Bingqian, Wait, Sarah J., Spainhower, Kyle B., Conley, Christopher C., Chen, Opal S., Guthrie, Matthew R., Soltero, Danny, Qiao, Yi, Huang, Xiaomeng, Tarapcsák, Szabolcs, Devarakonda, Siddhartha, Chalishazar, Milind D., Gertz, Jason, Moser, Justin C., Marth, Gabor, Puri, Sonam, Witt, Benjamin L., Spike, Benjamin T., Oliver, Trudy G.

“…Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single disease with poor outcomes. Distinct SCLC molecular subtypes have been…”
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Development of flax/carbon fibre hybrid composites for enhanced properties by Dhakal, H.N., Zhang, Z.Y., Guthrie, R., MacMullen, J., Bennett, N.

“…•A cost effective process of hybridisation is developed.•Water absorption reduced, mechanical properties were improved due to hybridisation.•Hybridised…”
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Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone by Forst, T., Guthrie, R., Goldenberg, R., Yee, J., Vijapurkar, U., Meininger, G., Stein, P.

“…Aim The efficacy and safety of canagliflozin, a sodium glucose co‐transporter 2 inhibitor, was evaluated in patients with type 2 diabetes mellitus (T2DM)…”
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MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion by Chalishazar, Milind D, Wait, Sarah J, Huang, Fang, Ireland, Abbie S, Mukhopadhyay, Anandaroop, Lee, Younjee, Schuman, Sophia S, Guthrie, Matthew R, Berrett, Kristofer C, Vahrenkamp, Jeffery M, Hu, Zeping, Kudla, Marek, Modzelewska, Katarzyna, Wang, Guoying, Ingolia, Nicholas T, Gertz, Jason, Lum, David H, Cosulich, Sabina C, Bomalaski, John S, DeBerardinis, Ralph J, Oliver, Trudy G

“…Small-cell lung cancer (SCLC) has been treated clinically as a homogeneous disease, but recent discoveries suggest that SCLC is heterogeneous. Whether…”
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Discussion on “Review of Physical and Numerical Approaches for the Study of Gas Stirring in Ladle Metallurgy” by Mazumdar, Dipak, Guthrie, R. I. L.

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Evaluating the performance of propagation models of flow-like landslides at regional scale by Crescenzo, L., Guthrie, R., Calvello, M.

“…Propagation models of flow-like landslides can be calibrated by comparing on-site evidence of past occurrences with the propagation paths and the deposition…”
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Origin and causes of the mammoth steppe: a story of cloud cover, woolly mammal tooth pits, buckles, and inside-out Beringia by Dale Guthrie, R

“…To account for the vastness of the northern arid steppes during Glacial episodes, I propose the proximate key variable was simply frequent clear skies. This…”
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Radiocarbon evidence of mid-Holocene mammoths stranded on an Alaskan Bering Sea island by Dale Guthrie, R

“…Island colonization and subsequent dwarfing of Pleistocene proboscideans is one of the more dramatic evolutionary and ecological occurrences, especially in…”
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Family matters: How MYC family oncogenes impact small cell lung cancer by Brägelmann, Johannes, Böhm, Stefanie, Guthrie, Matthew R., Mollaoglu, Gurkan, Oliver, Trudy G., Sos, Martin L.

“…Small cell lung cancer (SCLC) is one of the most deadly cancers and currently lacks effective targeted treatment options. Recent advances in the molecular…”
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Faunal record identifies Bering isthmus conditions as constraint to end-Pleistocene migration to the New World by Meiri, Meirav, Lister, Adrian M., Collins, Matthew J., Tuross, Noreen, Goebel, Ted, Blockley, Simon, Zazula, Grant D., van Doorn, Nienke, Dale Guthrie, R., Boeskorov, Gennady G., Baryshnikov, Gennady F., Sher, Andrei, Barnes, Ian

“…Human colonization of the New World is generally believed to have entailed migrations from Siberia across the Bering isthmus. However, the limited…”
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ASCL1 represses a SOX9 + neural crest stem-like state in small cell lung cancer by Olsen, Rachelle R, Ireland, Abbie S, Kastner, David W, Groves, Sarah M, Spainhower, Kyle B, Pozo, Karine, Kelenis, Demetra P, Whitney, Christopher P, Guthrie, Matthew R, Wait, Sarah J, Soltero, Danny, Witt, Benjamin L, Quaranta, Vito, Johnson, Jane E, Oliver, Trudy G

“…ASCL1 is a neuroendocrine lineage-specific oncogenic driver of small cell lung cancer (SCLC), highly expressed in a significant fraction of tumors. However,…”
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MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer by Dammert, Marcel A., Brägelmann, Johannes, Olsen, Rachelle R., Böhm, Stefanie, Monhasery, Niloufar, Whitney, Christopher P., Chalishazar, Milind D., Tumbrink, Hannah L., Guthrie, Matthew R., Klein, Sebastian, Ireland, Abbie S., Ryan, Jeremy, Schmitt, Anna, Marx, Annika, Ozretić, Luka, Castiglione, Roberta, Lorenz, Carina, Jachimowicz, Ron D., Wolf, Elmar, Thomas, Roman K., Poirier, John T., Büttner, Reinhard, Sen, Triparna, Byers, Lauren A., Reinhardt, H. Christian, Letai, Anthony, Oliver, Trudy G., Sos, Martin L.

“…MYC paralogs are frequently activated in small cell lung cancer (SCLC) but represent poor drug targets. Thus, a detailed mapping of MYC -paralog-specific…”
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The 6 August 2010 Mount Meager rock slide-debris flow, Coast Mountains, British Columbia: characteristics, dynamics, and implications for hazard and risk assessment by Guthrie, R. H, Friele, P, Allstadt, K, Roberts, N, Evans, S. G, Delaney, K. B, Roche, D, Clague, J. J, Jakob, M

“…A large rock avalanche occurred at 03:27:30 PDT, 6 August 2010, in the Mount Meager Volcanic Complex southwest British Columbia. The landslide initiated as a…”
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CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration by Liachko, Nicole F., McMillan, Pamela J., Guthrie, Chris R., Bird, Thomas D., Leverenz, James B., Kraemer, Brian C.

“…Objective Kinase hyperactivity occurs in both neurodegenerative disease and cancer. Lesions containing hyperphosphorylated aggregated TDP‐43 characterize…”
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Forest harvesting is associated with increased landslide activity during an extreme rainstorm on Vancouver Island, Canada by Goetz, J. N, Guthrie, R. H, Brenning, A

“…Safe operations of forest practices in mountainous regions require effective development planning to mitigate hazards posed by landslides. British Columbia,…”
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Cardiac fibroblasts influence cardiomyocyte phenotype in vitro by LaFramboise, W A, Scalise, D, Stoodley, P, Graner, S R, Guthrie, R D, Magovern, J A, Becich, M J

“…Cardiac fibroblasts impact myocardial development and remodeling through intercellular contact with cardiomyocytes, but less is known about noncontact,…”
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Ladle Shroud as a Flow Control Device for Tundish Operations by Morales-Higa, Ken, Guthrie, R. I. L., Isac, M., Morales, R. D.

“…The performance characteristics of a tundish, such as the flotation of inclusions and slag entrainment, are largely influenced by the fluid-flow phenomena…”
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Monoubiquitination Promotes Calpain Cleavage of the Protein Phosphatase 2A (PP2A) Regulatory Subunit α4, Altering PP2A Stability and Microtubule-associated Protein Phosphorylation by Watkins, Guy R., Wang, Ning, Mazalouskas, Matthew D., Gomez, Rey J., Guthrie, Chris R., Kraemer, Brian C., Schweiger, Susann, Spiller, Benjamin W., Wadzinski, Brian E.

“…Multiple neurodegenerative disorders are linked to aberrant phosphorylation of microtubule-associated proteins (MAPs). Protein phosphatase 2A (PP2A) is the…”
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