Search Results - "GUTHRIE, David J. S."

Identification of the region of non‐Aβ component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity by Bodles, Angela M., Guthrie, David J. S., Greer, Brett, Irvine, G. Brent

“…The non‐beta‐amyloid (Aβ) component of Alzheimer's disease amyloid (NAC) and its precursor α‐synuclein have been linked to amyloidogenesis in several…”
Get full text

Inhibition of fibril formation and toxicity of a fragment of α-synuclein by an N-methylated peptide analogue by Bodles, Angela M., El-Agnaf, Omar M.A., Greer, Brett, Guthrie, David J.S., Irvine, G.Brent

“…α-Synuclein has been linked to amyloidogenesis in Parkinson's disease and other neurodegenerative disorders. We have previously shown that a peptide comprising…”
Get full text

Toxicity of non‐Aβ component of Alzheimer's disease amyloid, and N‐terminal fragments thereof, correlates to formation of β‐sheet structure and fibrils by Bodles, Angela M., Guthrie, David J. S., Harriott, Patrick, Campbell, Pamela, Irvine, G. Brent

“…The non‐Aβ component of Alzheimer's disease amyloid (NAC) and its precursor α‐synuclein have been linked to amyloidogenesis in Alzheimer's disease (AD),…”
Get full text

Comparative studies on peptides representing the so-called tachykinin-like region of the Alzheimer Aβ peptide [Aβ(25–35)] by EL-AGNAF, Omar M. A., IRVINE, G. Brent, FITZPATRICK, Geraldine, GLASS, W. Kenneth, GUTHRIE, David J. S.

“…In an attempt to answer the question of whether or not the so-called tachykinin-like region of the Alzheimer β-amyloid protein [Aβ(25–35)] can act as a…”
Get full text

The N‐terminal region of non‐Aβ component of Alzheimer's Disease amyloid is responsible for its tendency to assume β‐sheet and aggregate to form fibrils by El‐Agnaf, Omar M. A., Bodles, Angela M., Guthrie, David J. S., Harriott, Patrick, Irvine, G. Brent

“…Examination of the N‐terminal sequence of non‐Aβ component of Alzheimer's Disease amyloid (NAC) revealed a degree of similarity to regions crucial for…”
Get full text

The influence of the central region containing residues 19−25 on the aggregation properties and secondary structure of Alzheimer's β‐amyloid peptide by El‐Agnaf, Omar M. A., Guthrie, David J. S., Walsh, Dominic M., Irvine, G. Brent

“…Alzheimer's β‐amyloid peptide (Aβ) is a 39‐ to 43‐amino‐acid peptide that is the major component of neuritic plaques found in Alzheimer's disease (AD). The…”
Get full text

Properties of some peptides related to amyloid beta-peptide by el-Agnaf, O M, Irvine, G B, Guthrie, D J, Walsh, D M

Get more information

Successful syntheses of beta amyloid-(25-35)-peptide: a difficult sequence by N-(9-fluorenylmethoxycarbonyl) chemistry by Guthrie, D J, el-Agnaf, O, Harriott, P, Irvine, G B, Walker, B

Get more information

Effects on oral bacteria of a peptide derived from human cathepsin G by Boomer, S, Coulter, W A, Guthrie, D J

Get more information

Inhibition of bovine cathepsin B by amino acid-derived nitriles by Picken, P P, Guthrie, D J, Walker, B

Get more information

A molecular dynamics study of Helix aspersa NPF by Leung, P S, Guthrie, D J, Irvine, G B, Shaw, C

Get more information

Neurokinin A analogues binding to isolated membranes from guinea-pig brain by Guthrie, D J, Abu Shanab, A A, Allen, J M, Irvine, G B, Walker, B

Get more information

Biological testing of some synthetic analogues of the salivary peptide, sialin by Coulter, W A, Guthrie, D J, Murray, S D, Walker, B

Get more information

1H-nuclear magnetic resonance conformational studies on synthetic analogues of gastrin-releasing peptide by Gray, J, Guthrie, D J, Walker, B, Nelson, J, Donnelly, M, Murphy, R F

Get more information

Synthesis, monitoring and structure-function studies on some neurokinin A analogues by Guthrie, D J, Abu Shanab, A A, Allen, J M, Irvine, G B, McFerran, N V, Walker, B

Get more information

An antagonist of neurokinin A, but not substance P, activity on tracheal smooth muscle from guinea-pig by Shanab, A A, Guthrie, D J, Irvine, G B, Murphy, R F, Walker, B, Allen, J M

Get more information

Action of some analogues of neurokinin A on the growth of skin and synovial fibroblasts in vitro by Abu Shanab, A A, Guthrie, D J, Hughes, A E, Mollan, R A, Murphy, R F, Walker, B

Get more information