Search Results - "GUTGEMANN, Ines"

MYC regulates the antitumor immune response through CD47 and PD-L1 by Casey, Stephanie C., Tong, Ling, Li, Yulin, Do, Rachel, Walz, Susanne, Fitzgerald, Kelly N., Gouw, Arvin M., Baylot, Virginie, Gütgemann, Ines, Eilers, Martin, Felsher, Dean W.

“…The MYC oncogene codes for a transcription factor that is overexpressed in many human cancers. Here we show that MYC regulates the expression of two immune…”
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Prognostic profiling of the immune cell microenvironment in Ewing´s Sarcoma Family of Tumors by Stahl, David, Gentles, Andrew J, Thiele, Ralf, Gütgemann, Ines

“…Ewing´s Sarcoma Family of Tumors (ESFT) are clinically aggressive bone and soft tissue tumors in children and young adults. Analysis of the immune tumor…”
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Lysine-specific demethylase 1 (LSD1) in hematopoietic and lymphoid neoplasms by Niebel, Dennis, Kirfel, Jutta, Janzen, Viktor, Höller, Tobias, Majores, Michael, Gütgemann, Ines

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Increased IgG4‐positive plasma cells in nodular‐sclerosing Hodgkin lymphoma: a diagnostic pitfall by Nowak, Verena, Agaimy, Abbas, Kristiansen, Glen, Gütgemann, Ines

“…Aims Despite increasing interest in the recently established immunoglobulin 4‐related disease (IgG4‐RD), its pathogenesis and aetiology remain largely unclear…”
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Prognostic Gene Expression, Stemness and Immune Microenvironment in Pediatric Tumors by Stahl, David, Knoll, Rainer, Gentles, Andrew J, Vokuhl, Christian, Buness, Andreas, Gütgemann, Ines

“…Pediatric tumors frequently arise from embryonal cells, often displaying a stem cell-like ("small round blue") morphology in tissue sections. Because recently…”
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The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling by Li, Jin, Riedt, Tamara, Goossens, Steven, Carrillo García, Carmen, Szczepanski, Sabrina, Brandes, Maria, Pieters, Tim, Dobrosch, Linne, Gütgemann, Ines, Farla, Natalie, Radaelli, Enrico, Hulpiau, Paco, Mallela, Nikhil, Fröhlich, Holger, La Starza, Roberta, Matteucci, Caterina, Chen, Tong, Brossart, Peter, Mecucci, Cristina, Huylebroeck, Danny, Haigh, Jody J., Janzen, Viktor

“…Epithelial-to-mesenchymal-transition (EMT) is critical for normal embryogenesis and effective postnatal wound healing, but is also associated with cancer…”
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Global levels of histone modifications predict prostate cancer recurrence by Ellinger, Jörg, Kahl, Philip, von der Gathen, Johannes, Rogenhofer, Sebastian, Heukamp, Lukas C., Gütgemann, Ines, Walter, Bernhard, Hofstädter, Ferdinand, Büttner, Reinhard, Müller, Stefan C., Bastian, Patrick J., von Ruecker, Alexander

“…PURPOSE Epigenetic alterations such as DNA methylation and histone modifications play important roles in carcinogenesis. It was reported that global histone…”
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Low BUB1 expression is an adverse prognostic marker in gastric adenocarcinoma by Stahl, David, Braun, Martin, Gentles, Andrew J, Lingohr, Philipp, Walter, Adeline, Kristiansen, Glen, Gütgemann, Ines

“…Gastric adenocarcinomas are associated with a poor prognosis due to the fact that the tumor has often metastasized by the time of diagnosis and prognostic…”
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Blastic plasmacytoid dendritic-cell neoplasia: a challenging case report by Koerber, Ruth-Miriam, Held, Stefanie A. E., Vonnahme, Maria, Feldmann, Georg, Wenzel, Joerg, Gütgemann, Ines, Brossart, Peter, Heine, Annkristin

“…Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an extremely rare disease that originates from dendritic cells and is associated with a poor overall…”
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Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma by Seitz, Volkhard, Butzhammer, Peter, Hirsch, Burkhard, Hecht, Jochen, Gütgemann, Ines, Ehlers, Anke, Lenze, Dido, Oker, Elisabeth, Sommerfeld, Anke, von der Wall, Edda, König, Christoph, Zinser, Christian, Spang, Rainer, Hummel, Michael

“…MYC is a key transcription factor involved in central cellular processes such as regulation of the cell cycle, histone acetylation and ribosomal biogenesis. It…”
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Macrophage frequency in the bone marrow correlates with morphologic subtype of myeloproliferative neoplasm by Molitor, David C. A., Boor, Peter, Buness, Andreas, Schneider, Rebekka K., Teichmann, Lino L., Körber, Ruth-Miriam, Horvath, Gabor L., Koschmieder, Steffen, Gütgemann, Ines

“…Bone marrow (BM) fibrosis in myeloproliferative neoplasms (MPNs) is associated with a poor prognosis. The development of myelofibrosis and differentiation of…”
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Fibroblast growth factor receptor 1 gene amplification in pancreatic ductal adenocarcinoma by Lehnen, Nils C, von Mässenhausen, Anne, Kalthoff, Holger, Zhou, Hui, Glowka, Tim, Schütte, Ute, Höller, Tobias, Riesner, Katarina, Boehm, Diana, Merkelbach-Bruse, Sabine, Kirfel, Jutta, Perner, Sven, Gütgemann, Ines

“…Aims Pancreatic ductal adenocarcinomas (PDACs) are chemoresistant, resulting in extremely poor survival of patients; therefore, novel molecular targets, even…”
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Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma by Patil, Mohini A., Gütgemann, Ines, Zhang, Ji, Ho, Coral, Cheung, Siu-Tim, Ginzinger, David, Li, Rui, Dykema, Karl J., So, Samuel, Fan, Sheung-Tat, Kakar, Sanjay, Furge, Kyle A., Büttner, Reinhard, Chen, Xin

“…Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide. We have previously characterized global gene expression patterns in HCC using…”
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Tumor Necrosis Factor Alpha- and Inducible Nitric Oxide Synthase-Producing Dendritic Cells Are Rapidly Recruited to the Bladder in Urinary Tract Infection but Are Dispensable for Bacterial Clearance by Engel, Daniel, Dobrindt, Ulrich, Tittel, André, Peters, Petra, Maurer, Juliane, Gütgemann, Ines, Kaissling, Brigitte, Kuziel, William, Jung, Steffen, Kurts, Christian

“…The role of dendritic cells (DC) in urinary tract infections (UTI) is unknown. These cells contribute directly to the innate defense against various viral and…”
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H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1 by Magerl, Christian, Ellinger, Jörg, MD, Braunschweig, Till, MD, Kremmer, Elisabeth, MD, Koch, Lin Kristin, MD, Höller, Tobias, Büttner, Reinhard, MD, Lüscher, Bernhard, PhD, Gütgemann, Ines, MD

“…Summary Methylation of core histones regulates chromatin structure and gene expression. Recent studies have demonstrated that these methylation patterns have…”
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Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis by Peng, Wen-Ming, Maintz, Laura, Allam, Jean-Pierre, Raap, Ulrike, Gütgemann, Ines, Kirfel, Jutta, Wardelmann, Eva, Perner, Sven, Zhao, Wei, Fimmers, Rolf, Walgenbach, Klaus, Oldenburg, Johannes, Schwartz, Lawrence B., Novak, Natalija

“…Mastocytosis is a rare heterogeneous disease characterized by increase of mast cells (MCs) in different organs. Neurotrophins (NTs) have been shown to promote…”
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Fibroblast growth factor receptor 1 gene amplification in gastric adenocarcinoma by Schäfer, Manuel H, Lingohr, Philipp, MD, Sträßer, Anke, MD, Lehnen, Nils C., MD, Braun, Martin, MD, Perner, Sven, MD, PhD, Höller, Tobias, Kristiansen, Glen, MD, Kalff, Jörg C., MD, Gütgemann, Ines, MD

“…Summary Gastric adenocarcinomas are associated with a poor prognosis due to the fact that the tumor has often metastasized by the time of diagnosis. Thus,…”
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The spleen microenvironment influences disease transformation in a mouse model of KITD816V-dependent myeloproliferative neoplasm by Pelusi, Natalie, Kosanke, Maike, Riedt, Tamara, Rösseler, Corinna, Seré, Kristin, Li, Jin, Gütgemann, Ines, Zenke, Martin, Janzen, Viktor, Schorle, Hubert

“…Activating mutations leading to ligand-independent signaling of the stem cell factor receptor KIT are associated with several hematopoietic malignancies. One…”
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Alterations of global histone H4K20 methylation during prostate carcinogenesis by Behbahani, Turang E, Kahl, Philip, von der Gathen, Johannes, Heukamp, Lukas C, Baumann, Claudia, Gütgemann, Ines, Walter, Bernhard, Hofstädter, Ferdinand, Bastian, Patrick J, von Ruecker, Alexander, Müller, Stefan C, Rogenhofer, Sebastian, Ellinger, Jörg

“…Global histone modifications have been implicated in the progression of various tumour entities. Our study was designed to assess global methylation levels of…”
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Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer by Ellinger, Jörg, Kahl, Philip, von der Gathen, Johannes, Heukamp, Lukas C., Gütgemann, Ines, Walter, Bernhard, Hofstädter, Ferdinand, Bastian, Patrick J., von Ruecker, Alexander, Müller, Stefan C., Rogenhofer, Sebastian

“…Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27)…”
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