Search Results - "GUSTAFSSON, Asa B"

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria by Zhong, Zhenyu, Umemura, Atsushi, Sanchez-Lopez, Elsa, Liang, Shuang, Shalapour, Shabnam, Wong, Jerry, He, Feng, Boassa, Daniela, Perkins, Guy, Ali, Syed Raza, McGeough, Matthew D., Ellisman, Mark H., Seki, Ekihiro, Gustafsson, Asa B., Hoffman, Hal M., Diaz-Meco, Maria T., Moscat, Jorge, Karin, Michael

“…Nuclear factor κB (NF-κB), a key activator of inflammation, primes the NLRP3-inflammasome for activation by inducing pro-IL-1β and NLRP3 expression. NF-κB,…”
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Mitochondrial turnover in the heart by Gottlieb, Roberta A, Gustafsson, Asa B

“…Mitochondrial quality control is increasingly recognized as an essential element in maintaining optimally functioning tissues. Mitochondrial quality control…”
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Recycle or die: The role of autophagy in cardioprotection by Gustafsson, Åsa B, Gottlieb, Roberta A

“…Abstract Autophagy is a highly conserved cellular process responsible for the degradation of long-lived proteins and organelles. Autophagy occurs at low levels…”
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Heart mitochondria: gates of life and death by Gustafsson, Åsa B., Gottlieb, Roberta A.

“…Mitochondria are important generators of energy, providing ATP through oxidative phosphorylation. However, mitochondria also monitor complex information from…”
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Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium by Gustafsson, Asa B

“…The Bcl-2 adenovirus E1B 19 kDa-interacting protein 3 (Bnip3) is a pro-apoptotic BH3-only protein associated with the pathogenesis of many diseases, including…”
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New roles for mitochondria in cell death in the reperfused myocardium by Ong, Sang-Bing, Gustafsson, Asa B

“…Mitochondria play an important role in regulating the life and death of cells. They provide the cell with energy via oxidative phosphorylation but can quickly…”
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Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak by Kubli, Dieter A, Ycaza, John E, Gustafsson, Asa B

“…Bnip3 is a pro-apoptotic member of the Bcl-2 family that is down-regulated in pancreatic cancers, which correlates with resistance to chemotherapy and a…”
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Mitochondrial Autophagy: An Essential Quality Control Mechanism for Myocardial Homeostasis by Thomas, Robert L., Gustafsson, Åsa B.

“…Efficient and functional mitochondrial networks are essential for myocardial contraction and cardiomyocyte survival. Mitochondrial autophagy (mitophagy) refers…”
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MCL1 is critical for mitochondrial function and autophagy in the heart by Thomas, Robert L, Gustafsson, Åsa B

“…MCL1 (myeloid cell leukemia sequence 1 [BCL2-related]) is an anti-apoptotic BCL2 family protein that is upregulated in several human cancers. In malignancies,…”
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Regulation of Autophagy by Metabolic and Stress Signaling Pathways in the Heart by Lee, Youngil, Lee, Hwa-Youn, Gustafsson, Åsa B

“…Autophagy is an essential process for the maintenance of cellular homeostasis in the heart under both normal and stress conditions. Autophagy is a key…”
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Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA by Yitzhaki, Smadar, Huang, Chengqun, Liu, Wayne, Lee, Youngil, Gustafsson, Åsa B., Mentzer, Robert M., Gottlieb, Roberta A.

“…We have shown that the cellular process of macroautophagy plays a protective role in HL-1 cardiomyocytes subjected to simulated ischemia/reperfusion (sI/R)…”
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The role of mitochondrial fission in cardiovascular health and disease by Quiles, Justin M., Gustafsson, Åsa B.

“…Mitochondria are organelles involved in the regulation of various important cellular processes, ranging from ATP generation to immune activation. A healthy…”
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Mitochondria and Mitophagy: The Yin and Yang of Cell Death Control by Kubli, Dieter A, Gustafsson, Åsa B

“…Mitochondria are primarily responsible for providing the contracting cardiac myocyte with a continuous supply of ATP. However, mitochondria can rapidly change…”
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Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes by Borillo, Gwynngelle A, Mason, Matt, Quijada, Pearl, Völkers, Mirko, Cottage, Christopher, McGregor, Michael, Din, Shabana, Fischer, Kimberlee, Gude, Natalie, Avitabile, Daniele, Barlow, Steven, Alvarez, Roberto, Truffa, Silvia, Whittaker, Ross, Glassy, Matthew S, Gustafsson, Asa B, Miyamoto, Shigeki, Glembotski, Christopher C, Gottlieb, Roberta A, Brown, Joan Heller, Sussman, Mark A

“…RATIONALE:Cardioprotective signaling mediates antiapoptotic actions through multiple mechanisms including maintenance of mitochondrial integrity. Pim-1 kinase…”
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Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process by Gustafsson, Åsa B, Dorn, 2nd, Gerald W

“…The central functions fulfilled by mitochondria as both energy generators essential for tissue homeostasis and gateways to programmed apoptotic and necrotic…”
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Autophagy in Ischemic Heart Disease by Gustafsson, Åsa B, Gottlieb, Roberta A

“…Autophagy is a major catabolic pathway by which mammalian cells degrade and recycle macromolecules and organelles. It plays a critical role in removing protein…”
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Role of apoptosis in cardiovascular disease by Lee, Youngil, Gustafsson, Åsa B

“…Apoptosis plays a key role in the pathogenesis in a variety of cardiovascular diseases due to loss of terminally differentiated cardiac myocytes. Cardiac…”
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Mending a broken heart: the role of mitophagy in cardioprotection by Moyzis, Alexandra G, Sadoshima, Junichi, Gustafsson, Åsa B

“…The heart is highly energy dependent with most of its energy provided by mitochondrial oxidative phosphorylation. Mitochondria also play a role in many other…”
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Mitochondrial quality surveillance: mitophagy in cardiovascular health and disease by Diao, Rachel Y, Gustafsson, Åsa B

“…Selective autophagy of mitochondria, known as mitophagy, is a major quality control pathway in the heart that is involved in removing unwanted or dysfunctional…”
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Therapeutic Targeting of Autophagy: Potential and Concerns in Treating Cardiovascular Disease by Orogo, Amabel M, Gustafsson, Åsa B

“…Autophagy is an evolutionarily conserved process by which long-lived proteins and organelles are sequestered by autophagosomes and subsequently degraded by…”
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