Search Results - "GUSTAFSON, Kirk R."

Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti by Di, Xiaxia, Hardardottir, Ingibjorg, Freysdottir, Jona, Wang, Dongdong, Gustafson, Kirk R, Omarsdottir, Sesselja, Molinski, Tadeusz F

“…Geobarrettin D ( ), a new bromoindole alkaloid, was isolated from the marine sponge collected from Icelandic waters. Its structure was elucidated by 1D, and 2D…”
Get full text

Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, from Phyllanthus engleri by Ratnayake, Ranjala, Covell, David, Ransom, Tanya T, Gustafson, Kirk R, Beutler, John A

“…An extract from Phyllanthus engleri was identified in a bioinformatic analysis of NCI 60-cell natural product extract screening data that selectively inhibited…”
Get full text

Four New Pregnane-10,2-carbolactones from an Epipolasis sp. Marine Sponge by Kang, Unwoo, Wang, Dongdong, Bokesch, Heidi R., Gustafson, Kirk R.

“…Four new pregnane steroids, 3β,4β,16β-trihydroxypregna-5,17-diene-10,2-carbolactone (1), 16β-acetoxy-3β,4β-dihydroxypregna-5,17-diene-10,2-carbolactone (2),…”
Get full text

Hypeisoxazole A, a Racemic Pair of Tetrahydroisoxazole-Fused Benzylisoquinoline Alkaloids from Hypecoum erectum and Structural Revision of Hypecoleptopine by Sun, Pan-Ting, Cao, Yan-Gang, Xue, Gui-Min, Li, Meng, Zhang, Chun-Lei, Zhao, Fang, Cao, Zheng-Yu, Wang, Dongdong, Gustafson, Kirk R, Zheng, Xiao-Ke, Feng, Wei-Sheng, Chen, Hui

“…(±)-Hypeisoxazole A ( ), a racemic pair of rearranged benzylisoquinoline alkaloids possessing an unprecedented diindeno[2,1-c:2',1'-d] isoxazole scaffold, was…”
Get full text

Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge Neopetrosia sp by Wang, Dongdong, Jiang, Wei, Kim, Chang-Kwon, Bokesch, Heidi R, Woldemichael, Girma M, Gryder, Berkley E, Shern, John F, Khan, Javed, O’Keefe, Barry R, Beutler, John A, Gustafson, Kirk R

“…Neopetrothiazide (1), a pentacyclic isoquinoline quinone, was isolated from a Neopetrosia sp. sponge. The structure elucidation was facilitated by utilizing…”
Get full text

Marine pharmacology in 2005–2006: Antitumour and cytotoxic compounds by Mayer, Alejandro M.S, Gustafson, Kirk R

“…Abstract During 2005 and 2006, marine pharmacology research directed towards the discovery and development of novel antitumour agents was reported in 171…”
Get full text

Identification of natural product modulators of Merkel cell carcinoma cell growth and survival by Smith, Emily A., Hill, Natasha T., Gelb, Tara, Garman, Khalid A., Goncharova, Ekaterina I., Bokesch, Heidi R., Kim, Chang-Kwon, Wendt, Karen L., Cichewicz, Robert H., Gustafson, Kirk R., Brownell, Isaac, Henrich, Curtis J.

“…Merkel cell carcinoma (MCC) is a rare, but aggressive skin cancer the incidence of which has increased significantly in recent years. The majority of MCCs have…”
Get full text

Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species by Espindola, Laila S, Dusi, Renata G, Demarque, Daniel P, Braz-Filho, Raimundo, Yan, Pengcheng, Bokesch, Heidi R, Gustafson, Kirk R, Beutler, John A

“…The new pentacyclic triterpene 11 -hydroxypristimerin ( ), along with the known metabolites pristimerin ( ), 6-oxopristimerol ( ) and vitideasin ( ), were…”
Get full text

Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea by Kim, Chang-Kwon, Krumpe, Lauren R. H., Smith, Emily, Henrich, Curtis J., Brownell, Isaac, Wendt, Karen L., Cichewicz, Robert H., O’Keefe, Barry R., Gustafson, Kirk R.

“…A new 11 amino acid linear peptide named roseabol A (1) and the known compound 13-oxo-trans-9,10-epoxy-11(E)-octadecenoic acid (2) were isolated from the…”
Get full text

Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp by Shin, Hee Jae, Rashid, Mohammad A., Cartner, Laura K., Bokesch, Heidi R., Wilson, Jennifer A., McMahon, James B., Gustafson, Kirk R.

“…[Display omitted] Two new HIV-inhibitory depsipeptides, stellettapeptins A (1) and B (2), were isolated from an extract of the marine sponge Stelletta sp.,…”
Get full text

Suberitamides A-C, Aryl Alkaloids from a Pseudosuberites sp. Marine Sponge that Inhibit Cbl-b Ubiquitin Ligase Activity by Kim, Chang-Kwon, Wang, Dongdong, Wilson, Brice A P, Saurí, Josep, Voeller, Donna, Lipkowitz, Stanley, O'Keefe, Barry R, Gustafson, Kirk R

“…Three new aryl alkaloids named suberitamides A-C ( - ), were isolated from an extract of the marine sponge sp. collected along the coast of North Carolina…”
Get full text

Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge Astrosclera willeyana by Jiang, Wei, Wang, Dongdong, Wilson, Brice A P, Kang, Unwoo, Bokesch, Heidi R, Smith, Emily A, Wamiru, Antony, Goncharova, Ekaterina I, Voeller, Donna, Lipkowitz, Stanley, O'Keefe, Barry R, Gustafson, Kirk R

“…An extract of the coralline demosponge inhibited the ubiquitin ligase activity of the immunomodulatory protein Cbl-b. The bioassay-guided separation of the…”
Get full text

Biotransformed Metabolites of the Hop Prenylflavanone Isoxanthohumol by Kim, Hyun Jung, Yim, Soon-Ho, Han, Fubo, Kang, Bok Yun, Choi, Hyun Jin, Jung, Da-Woon, Williams, Darren R, Gustafson, Kirk R, Kennelly, Edward J, Lee, Ik-Soo

“…A metabolic conversion study on microbes is known as one of the most useful tools to predict the xenobiotic metabolism of organic compounds in mammalian…”
Get full text

Isolation, Structural Elucidation, and Absolute Stereochemistry of Enigmazole A, a Cytotoxic Phosphomacrolide from the Papua New Guinea Marine Sponge Cinachyrella enigmatica by Oku, Naoya, Takada, Kentaro, Fuller, Richard W, Wilson, Jennifer A, Peach, Megan L, Pannell, Lewis K, McMahon, James B, Gustafson, Kirk R

“…Enigmazole A (1), a novel phosphate-containing macrolide, was isolated from a Papua New Guinea collection of the marine sponge Cinachyrella enigmatica. The…”
Get full text

Sesterterpenoids: chemistry, biology, and biosynthesis by Li, Keke, Gustafson, Kirk R

“…Covering: July 2012 to December 2019Over the last seven years, expanding research efforts focused on sesterterpenoids has led to the isolation, identification,…”
Get more information

Cyanovirin-N Inhibits Hepatitis C Virus Entry by Binding to Envelope Protein Glycans by Helle, François, Wychowski, Czeslaw, Vu-Dac, Ngoc, Gustafson, Kirk R., Voisset, Cécile, Dubuisson, Jean

“…Inhibition of viruses at the stage of viral entry provides a route for therapeutic intervention. Because of difficulties in propagating hepatitis C virus (HCV)…”
Get full text

Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp by Kim, Chang-Kwon, Gustafson, Kirk R

“…Four new merohexapenoids named calyxaprenols A-D (1 - 4), together with the known compound haliclotriol A (5), have been isolated from the marine sponge Calyx…”
Get full text

Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models by Harris, Emily M, Strope, Jonathan D, Beedie, Shaunna L, Huang, Phoebe A, Goey, Andrew K L, Cook, Kristina M, Schofield, Christopher J, Chau, Cindy H, Cadelis, Melissa M, Copp, Brent R, Gustafson, Kirk R, Figg, William D

“…Elements of the hypoxia inducible factor (HIF) transcriptional system, a key regulator of the cellular hypoxic response, are up-regulated in a range of cancer…”
Get full text

Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum by Zhao, Min, Cheng, Shimiao, Yuan, Weiping, Xi, Yiyuan, Li, Xiubao, Dong, Jianyong, Huang, Kexin, Gustafson, Kirk R, Yan, Pengcheng

“…Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were…”
Get full text

Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 by Blees, Johanna S, Bokesch, Heidi R, Rübsamen, Daniela, Schulz, Kathrin, Milke, Larissa, Bajer, Magdalena M, Gustafson, Kirk R, Henrich, Curtis J, McMahon, James B, Colburn, Nancy H, Schmid, Tobias, Brüne, Bernhard

“…Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized…”
Get full text