Search Results - "GURUSAMY, Devikala"

The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity by Gautam, Sanjivan, Fioravanti, Jessica, Zhu, Wei, Le Gall, John B., Brohawn, Philip, Lacey, Neal E., Hu, Jinhui, Hocker, James D., Hawk, Nga Voong, Kapoor, Veena, Telford, William G., Gurusamy, Devikala, Yu, Zhiya, Bhandoola, Avinash, Xue, Hai-Hui, Roychoudhuri, Rahul, Higgs, Brandon W., Restifo, Nicholas P., Bender, Timothy P., Ji, Yun, Gattinoni, Luca

“…Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here, we found that the transcription factor c-Myb…”
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Bile acid-induced “Minority MOMP” promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1 by Xu, Yuan, Surman, Deborah R., Diggs, Laurence, Xi, Sichuan, Gao, Shaojian, Gurusamy, Devikala, McLoughlin, Kaitlin, Drake, Justin, Feingold, Paul, Brown, Kate, Wangsa, Danny, Wangsa, Darawalee, Zhang, Xi, Ried, Thomas, Davis, Jeremy L., Hernandez, Jonathan, Hoang, Chuong D., Souza, Rhonda F., Schrump, David S., Taylor Ripley, R.

“…Barrett’s esophagus (BE) is associated with reflux and is implicated the development of esophageal adenocarcinoma (EAC). Apoptosis induces cell death through…”
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LPS Tolerance Inhibits Cellular Respiration and Induces Global Changes in the Macrophage Secretome by Gillen, Joseph, Ondee, Thunnicha, Gurusamy, Devikala, Issara-Amphorn, Jiraphorn, Manes, Nathan P, Yoon, Sung Hwan, Leelahavanichkul, Asada, Nita-Lazar, Aleksandra

“…Inflammatory response plays an essential role in the resolution of infections. However, inflammation can be detrimental to an organism and cause irreparable…”
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Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth by GURUSAMY, Devikala, GRAY, Jerilyn K, PATHROSE, Peterson, KULKARNI, Rishikesh M, FINKLEMAN, Fred D, WALTZ, Susan E

“…Ron receptor kinase (MST1R) is important in promoting epithelial tumorigenesis, but the potential contributions of its specific expression in stromal cells…”
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Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System by Vizcardo, Raul, Klemen, Nicholas D., Islam, S.M. Rafiqul, Gurusamy, Devikala, Tamaoki, Naritaka, Yamada, Daisuke, Koseki, Haruhiko, Kidder, Benjamin L., Yu, Zhiya, Jia, Li, Henning, Amanda N., Good, Meghan L., Bosch-Marce, Marta, Maeda, Takuya, Liu, Chengyu, Abdullaev, Zied, Pack, Svetlana, Palmer, Douglas C., Stroncek, David F., Ito, Fumito, Flomerfelt, Francis A., Kruhlak, Michael J., Restifo, Nicholas P.

“…Induced pluripotent stem cell (iPSC)-derived T cells may provide future therapies for cancer patients, but those generated by current methods, such as the…”
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Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice by Ondee, Thunnicha, Gillen, Joseph, Visitchanakun, Peerapat, Somparn, Poorichaya, Issara-Amphorn, Jiraphorn, Dang Phi, Cong, Chancharoenthana, Wiwat, Gurusamy, Devikala, Nita-Lazar, Aleksandra, Leelahavanichkul, Asada

“…In patients with active lupus, spontaneous endotoxemia and possibly tolerance to lipopolysaccharide (LPS) is a potentially adverse complication. Similarly,…”
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Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma by Leko, Vid, Cafri, Gal, Yossef, Rami, Paria, Biman, Hill, Victoria, Gurusamy, Devikala, Zheng, Zhili, Gartner, Jared J, Prickett, Todd D, Goff, Stephanie L, Robbins, Paul, Lu, Yong-Chen, Rosenberg, Steven A

“…The adoptive transfer of naturally occurring T cells that recognize cancer neoantigens has led to durable tumor regressions in select patients with cancer…”
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Specific recognition of an FGFR2 fusion by tumor infiltrating lymphocytes from a patient with metastatic cholangiocarcinoma by White, Bradley Sinclair, Sindiri, Sivasish, Hill, Victoria, Gasmi, Billel, Nah, Shirley, Gartner, Jared J, Prickett, Todd D, Li, Yong, Gurusamy, Devikala, Robbins, Paul, Rosenberg, Steven A, Leko, Vid

“…BackgroundMetastatic cholangiocarcinoma (CC), a form of gastrointestinal cancer that originates from the bile ducts, cannot be cured by currently available…”
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Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice by Marshall, Aaron M, McClaine, Rebecca J, Gurusamy, Devikala, Gray, Jerilyn K, Lewnard, Kara E, Khan, Sohaib A, Waltz, Susan E

“…The receptor tyrosine kinase family includes many transmembrane proteins with diverse physiological and pathophysiological functions. The involvement of…”
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Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer by Krishna, Sri, Lowery, Frank J, Copeland, Amy R, Bahadiroglu, Erol, Mukherjee, Ratnadeep, Jia, Li, Anibal, James T, Sachs, Abraham, Adebola, Serifat O, Gurusamy, Devikala, Yu, Zhiya, Hill, Victoria, Gartner, Jared J, Li, Yong F, Parkhurst, Maria, Paria, Biman, Kvistborg, Pia, Kelly, Michael C, Goff, Stephanie L, Altan-Bonnet, Grégoire, Robbins, Paul F, Rosenberg, Steven A

“…Adoptive T cell therapy (ACT) using ex vivo-expanded autologous tumor-infiltrating lymphocytes (TILs) can mediate complete regression of certain human cancers…”
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Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis by Gurusamy, Devikala, Ruiz-Torres, Sasha J., Johnson, Abby L., Smith, Dana A., Waltz, Susan E.

“…•HGFL is expressed in both the epithelial and stromal compartments of developing murine mammary glands.•HGFL deficiency delays early postnatal mammary gland…”
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T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy by Yamamoto, Tori N, Lee, Ping-Hsien, Vodnala, Suman K, Gurusamy, Devikala, Kishton, Rigel J, Yu, Zhiya, Eidizadeh, Arash, Eil, Robert, Fioravanti, Jessica, Gattinoni, Luca, Kochenderfer, James N, Fry, Terry J, Aksoy, Bulent Arman, Hammerbacher, Jeffrey E, Cruz, Anthony C, Siegel, Richard M, Restifo, Nicholas P, Klebanoff, Christopher A

“…Across clinical trials, T cell expansion and persistence following adoptive cell transfer (ACT) have correlated with superior patient outcomes. Herein, we…”
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Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells by Lee, Ping-Hsien, Yamamoto, Tori N, Gurusamy, Devikala, Sukumar, Madhusudhanan, Yu, Zhiya, Hu-Li, Jane, Kawabe, Takeshi, Gangaplara, Arunakumar, Kishton, Rigel J, Henning, Amanda N, Vodnala, Suman K, Germain, Ronald N, Paul, William E, Restifo, Nicholas P

“…Host conditioning has emerged as an important component of effective adoptive cell transfer-based immunotherapy for cancer. High levels of IL-1β are induced by…”
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Novel "Elements" of Immune Suppression within the Tumor Microenvironment by Gurusamy, Devikala, Clever, David, Eil, Robert, Restifo, Nicholas P

“…Adaptive evolution has prompted immune cells to use a wide variety of inhibitory signals, many of which are usurped by tumor cells to evade immune…”
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CD4+ T Cell Help Selectively Enhances High-Avidity Tumor Antigen-Specific CD8+ T Cells by Zhu, Ziqiang, Cuss, Steven M, Singh, Vinod, Gurusamy, Devikala, Shoe, Jennifer L, Leighty, Robert, Bronte, Vincenzo, Hurwitz, Arthur A

“…Maintaining antitumor immunity remains a persistent impediment to cancer immunotherapy. We and others have previously reported that high-avidity CD8(+) T cells…”
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A role for IL-13 in the progression of prostate tumors (TUM10P.1046) by Gurusamy, Devikala, Shoe, Jennifer, Hocker, James, Hurwitz, Arthur

“…IL-13 is predominantly a Th2-derived cytokine that displays a variety of effects on inflammatory and stromal cells. Receptors for IL-13 are expressed by…”
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Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy by Klebanoff, Christopher A, Crompton, Joseph G, Leonardi, Anthony J, Yamamoto, Tori N, Chandran, Smita S, Eil, Robert L, Sukumar, Madhusudhanan, Vodnala, Suman K, Hu, Jinhui, Ji, Yun, Clever, David, Black, Mary A, Gurusamy, Devikala, Kruhlak, Michael J, Jin, Ping, Stroncek, David F, Gattinoni, Luca, Feldman, Steven A, Restifo, Nicholas P

“…Adoptive immunotherapies using T cells genetically redirected with a chimeric antigen receptor (CAR) or T cell receptor (TCR) are entering mainstream clinical…”
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Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies by Gurusamy, Devikala, Henning, Amanda N., Yamamoto, Tori N., Yu, Zhiya, Zacharakis, Nikolaos, Krishna, Sri, Kishton, Rigel J., Vodnala, Suman K., Eidizadeh, Arash, Jia, Li, Kariya, Christine M., Black, Mary A., Eil, Robert, Palmer, Douglas C., Pan, Jenny H., Sukumar, Madhusudhanan, Patel, Shashank J., Restifo, Nicholas P.

“…T cells are central to all currently effective cancer immunotherapies, but the characteristics defining therapeutically effective anti-tumor T cells have not…”
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Developing the Next Generation of iPSC Cell-Based Immunotherapies by Vizcardo, Raul, Klemen, Nicholas Donald, Islam, Rafiqul, Gurusamy, Devikala, Tamaoki, Naritaka, Jia, Li, Yu, Zhiya, Hennings, Amanda N, Maeda, Takuya, Bosch-Marce, Marta, Good, Meghan L, Pack, Svetlana, Stroncek, David F., Flomerfelt, Francis A, Kruhlak, Michael J, Restifo, Nicholas Phillip

“…T cells are potentially curative for patients with metastatic cancer, but many patients with cancer have T cells that are ‘terminally differentiated’, a…”
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Ron receptor signaling is protective against DSS-induced colitis in mice by Kulkarni, Rishikesh M, Stuart, William D, Gurusamy, Devikala, Waltz, Susan E

“…Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the intestine that result in painful and debilitating complications. Currently no cure…”
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