Search Results - "GURTU, Vikram"

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients by Michelakis, Evangelos D, Gurtu, Vikram, Webster, Linda, Barnes, Gareth, Watson, Geoffrey, Howard, Luke, Cupitt, John, Paterson, Ian, Thompson, Richard B, Chow, Kelvin, O'Regan, Declan P, Zhao, Lan, Wharton, John, Kiely, David G, Kinnaird, Adam, Boukouris, Aristeidis E, White, Chris, Nagendran, Jayan, Freed, Darren H, Wort, Stephen J, Gibbs, J Simon R, Wilkins, Martin R

“…Pulmonary arterial hypertension (PAH) is a progressive vascular disease with a high mortality rate. It is characterized by an occlusive vascular remodeling due…”
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A miR-208–Mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension by Paulin, Roxane, Sutendra, Gopinath, Gurtu, Vikram, Dromparis, Peter, Haromy, Alois, Provencher, Steeve, Bonnet, Sebastien, Michelakis, Evangelos D

“…RATIONALE:Right ventricular (RV) failure is a major cause of morbidity and mortality in pulmonary hypertension, but its mechanism remains unknown. Myocyte…”
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Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility by NAGENDRAN, Jayan, ARCHER, Stephen L, LIGHT, Peter E, DYCK, Jason R. B, MICHELAKIS, Evangelos D, SOLIMAN, Daniel, GURTU, Vikram, MOUDGIL, Rohit, HAROMY, Alois, AUBIN, Chantal St, WEBSTER, Linda, REBEYKA, Ivan M, ROSS, David B

“…Sildenafil was recently approved for the treatment of pulmonary arterial hypertension. The beneficial effects of phosphodiesterase type 5 (PDE5) inhibitors in…”
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Interaction with p53 explains a pro-proliferative function for VHL in cancer by Kinnaird, Adam, Boukouris, Aristeidis E., Saleme, Bruno, Dromparis, Peter, Zervopoulos, Sotirios D., Gurtu, Vikram, Sutendra, Gopinath, Michelakis, Evangelos D.

“…The von Hippel-Lindau (VHL) protein binds and degrades hypoxia-inducible factors (HIF) hydroxylated by prolyl-hydroxylases under normoxia. Although originally…”
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Emerging Therapies and Future Directions in Pulmonary Arterial Hypertension by Gurtu, Vikram, MD, Michelakis, Evangelos D., MD

“…Abstract Pulmonary arterial hypertension (PAH) is a complex obliterative vascular disease. It remains deadly despite an explosion of basic research over the…”
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A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted by Nagendran, Jayan, MD, Gurtu, Vikram, BSc, Fu, David Z., BSc, Dyck, Jason R.B., PhD, Haromy, Al, BSc, Ross, David B., MD, Rebeyka, Ivan M., MD, Michelakis, Evangelos D., MD

“…Objectives The right ventricle fails quickly after increases in its afterload (ie, pulmonary hypertension) compared with the left ventricle (ie, systemic…”
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The role of exercise right heart catheterization to guide pulmonary hypertension therapy in older adults by Mak, Susanna, Kolker, Shimon, Girdharry, Natasha R., Bentley, Robert F., Valle, Felipe H., Gurtu, Vikram, Mok, K. H., Moric, Jakov, Thenganatt, John, Granton, John T.

“…The spectrum of patients referred for suspected pulmonary arterial hypertension (PAH) includes a population with clinical features suggestive of pulmonary…”
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Body Habitus Considerations During Right Heart Catheterization by Girdharry, Natasha R., Bentley, Robert F., Valle, Felipe H., Karvasarski, Elizabeth, Osman, Sinan, Gurtu, Vikram, Kolker, Shimon, Mak, Susanna

“…Obese and overweight body habitus are common among patients undergoing right heart catheterization for suspected pulmonary hypertension, but previous studies…”
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Cell-Based Gene Therapy in Pulmonary Arterial Hypertension: Journeys in Translational Medicine by Gurtu, Vikram, Michelakis, Evangelos

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Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity by Saleme, Bruno, Gurtu, Vikram, Zhang, Yongneng, Kinnaird, Adam, Boukouris, Aristeidis E, Gopal, Keshav, Ussher, John R, Sutendra, Gopinath

“…Chemotherapy-induced cardiotoxicity (CIC) is a common clinical problem that compromises effective anticancer therapies. Many chemotherapeutics (including…”
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Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans by Paulin, Roxane, Dromparis, Peter, Sutendra, Gopinath, Gurtu, Vikram, Zervopoulos, Sotirios, Bowers, Lyndsay, Haromy, Alois, Webster, Linda, Provencher, Steeve, Bonnet, Sebastien, Michelakis, Evangelos D.

“…Suppression of mitochondrial function promoting proliferation and apoptosis suppression has been described in the pulmonary arteries and extrapulmonary tissues…”
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A Paradigm Shift Is Needed in the Field of Pulmonary Arterial Hypertension for Its Entrance Into the Precision Medicine Era by Gurtu, Vikram, Michelakis, Evangelos D

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Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase by Kinnaird, Adam, Dromparis, Peter, Saleme, Bruno, Gurtu, Vikram, Watson, Kristalee, Paulin, Roxane, Zervopoulos, Sotirios, Stenson, Trevor, Sutendra, Gopinath, Pink, Desmond B, Carmine-Simmen, Katia, Moore, Ronald, Lewis, John D, Michelakis, Evangelos D

“…Abstract Background Clear-cell renal cell carcinoma (ccRCC) exhibits suppressed mitochondrial function and preferential use of glycolysis even in normoxia,…”
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MP60-14 THE VON HIPPEL LINDAU (VHL) TUMOR SUPPRESSOR INHIBITS P53 TARGET GENE EXPRESSION TO PROMOTE APOPTOSIS-RESISTANCE IN CANCER by Kinnaird, Adam, Dromparis, Peter, Boukouris, Aristeidis, Gurtu, Vikram, Saleme, Bruno, Zervopoulos, Sotirios, Sutendra, Gopinath, Michelakis, Evangelos

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Hemodynamic reserve predicts early right heart failure after LVAD implantation by Read, Jacob M., Azih, Nnamdi I., Peters, Carli J., Gurtu, Vikram, Vishram-Nielsen, Julie K, Wright, Stephen P., Alba, Ana Carolina, Gregoski, Mathew J., Pilch, Nicole A., Hsu, Steven, Genuardi, Michael V., Inampudi, Chakradhari, Jackson, Gregory R., Pope, Nicholas, Witer, Lucas P., Kilic, Arman, Houston, Brian A., Mak, Susanna, Birati, Edo Y., Tedford, Ryan J.

“…Early right heart failure (RHF) remains a major source of morbidity and mortality after left ventricular assist device (LVAD) implantation, yet efforts to…”
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Abstract 19386: The Mitochondrial Deacetylase Sirtuin 3 (sirt3) is Important in the Pathogenesis of Both Pulmonary Hypertension and Pulmonary Fibrosis: Potential for an “Overlap Syndrome” and a Common Therapy? by Paulin, Roxane, Zang, Hengjia, Boukouris, Aristeidis, Gurtu, Vikram, Haromy, Alois, Michelakis, Evangelos D

“…IntroductionPulmonary arterial hypertension (PAH) is often associated with interstitial lung disease, like idiopathic pulmonary fibrosis (IPF). IPF pulmonary…”
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Abstract 19353: Prohibitin: A Potential Circulating Mitokine That May be Involved in Pulmonary Arterial Hypertension by PAULIN, Roxane, Kinnaird, Adam, Boukouris, Aristeidis, Gurtu, Vikram, Haromy, Alois, Michelakis, Evangelos D

“…IntroductionIn Pulmonary Arterial Hypertension (PAH), a “cancer-like” mitochondrial suppression in pulmonary vascular cells underlies in part the apoptosis…”
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Abstract 18488: Metabolic Modulation of the Diseased Human Lung; A Translational, Novel ex vivo Lung Perfusion Model by Gurtu, Vikram, Kinnaird, Adam, White, Christopher, Paulin, Roxane, Freed, Darren, Nagendran, Jayan, Michelakis, Evangelos

“…IntroductionPulmonary arterial hypertension (PAH) and idiopathic pulmonary fibrosis (IPF) are deadly diseases that often require lung transplantation…”
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MP85-01 MYOCYTE ENHANCER FACTOR 2A (MEF2A) IS UP-REGULATED IN CLEAR CELL RENAL CELL CARCINOMA by Kinnaird, Adam, Saleme, Bruno, Gurtu, Vikram, Zervopoulos, Sotirios, Boukouris, Aristeidis, Haromy, Alois, Stenson, Trevor, Watson, Kristalee, Dromparis, Peter, Michelakis, Evangelos

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Abstract 18991: A Mir-208-mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension by Paulin, Roxane, Sutendra, Gopinath, Gurtu, Vikram, Dromparis, Peter, Michelakis, Evangelos D

“…Abstract only Right Ventricular Failure (RVF) is the major cause of morbidity and mortality in PHT but remains understudied compared to left ventricular…”
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