Search Results - "GURNEY, E. M"

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity by Yan, Riqiang, Gurney, Mark E, Bienkowski, Michael J, Shuck, Mary E, Miao, Huiyi, Tory, Monica C, Pauley, Adele M, Brashler, John R, Stratman, Nancy C, Mathews, W. Rodney, Buhl, Allen E, Carter, Donald B, Tomasselli, Alfredo G, Parodi, Luis A, Heinrikson, Robert L

“…Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant Alzheimer's disease. Cleavage of APP by unidentified proteases,…”
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Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis by Dal Canto, MC, Gurney, ME

“…Transgenic mice expressing mutant Cu,Zn superoxide dismutase (SOD), containing a substitution of glycine at position 93 by alanine, develop disease prevalently…”
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"sparse" temporal sampling in auditory fMRI by Hall, Deborah A., Haggard, Mark P., Akeroyd, Michael A., Palmer, Alan R., Summerfield, A. Quentin, Elliott, Michael R., Gurney, Elaine M., Bowtell, Richard W.

“…The use of functional magnetic resonance imaging (fMRI) to explore central auditory function may be compromised by the intense bursts of stray acoustic noise…”
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Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS by Hall, Edward D., Oostveen, Jo A., Gurney, Mark E.

“…Transgenic mice that highly over‐express a mutated human CuZn superoxide dismutase (SOD1) gene [gly93→ala; TgN(SOD1‐G93A)G1H line] found in some patients with…”
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Protein Oxidative Damage in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis by Andrus, Paula K., Fleck, Timothy J., Gurney, Mark E., Hall, Edward D.

“…: The Gly93→Ala mutation in the Cu,Zn superoxide dismutase (Cu,Zn‐SOD) gene (SOD1) found in some familial amyotrophic lateral sclerosis (FALS) patients has…”
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Motor Neuron Degeneration in Mice That Express a Human Cu,Zn Superoxide Dismutase Mutation by Gurney, Mark E., Pu, Haifeng, Chiu, Arlene Y., Mauro C. Dal Canto, Polchow, Cynthia Y., Alexander, Denise D., Caliendo, Jan, Hentati, Afif, Kwon, Young W., Deng, Han-Xiang, Chen, Wenje, Zhai, Ping, Sufit, Robert L., Siddique, Teepu

“…Mutations of human Cu,Zn superoxide dismutase (SOD) are found in about 20 percent of patients with familial amyotrophic lateral sclerosis (ALS). Expression of…”
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Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS) by Dal Canto, Mauro C., Gurney, Mark E.

“…Two different lines of mice, G1 and G20, carrying a transgene for a mutant form of Cu,Zn SOD, found in a family with familial amyotrophic lateral sclerosis…”
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The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies by Gurney, Mark E

“…The discovery of mutations in the human SOD1 gene encoding Cu,Zn superoxide dismutase (Cu,Zn SOD) in patients with familial amyotrophic lateral sclerosis (ALS)…”
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Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor by Gurney, ME, Yamamoto, H, Kwon, Y

“…Ciliary neurotrophic factor (CNTF) and basic fibroblast growth factor (bFGF) were tested for effects on sprouting by motor neurons innervating the adult mouse…”
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Transgenic Mice Carrying a Human Mutant Superoxide Dismutase Transgene Develop Neuronal Cytoskeletal Pathology Resembling Human Amyotrophic Lateral Sclerosis Lesions by Tu, Pang-Hsien, Raju, Pramod, Robinson, Kathryn A., Gurney, Mark E., Trojanowski, John Q., Virginia M.-Y. Lee

“…Mutations in the human Cu,Zn superoxide dismutase gene (SOD1) are found in 20% of kindreds with familial amyotrophic lateral sclerosis. Transgenic mice (line…”
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Human platelets contain brain-derived neurotrophic factor by Yamamoto, H, Gurney, ME

“…Neurotrophic support to peripheral sensory neurons is provided by 2 factors of related sequence, NGF and brain-derived neurotrophic factor (BDNF). NGF is…”
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Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation by Ferrante, R J, Shinobu, L A, Schulz, J B, Matthews, R T, Thomas, C E, Kowall, N W, Gurney, M E, Beal, M F

“…Mutations in copper/zinc superoxide dismutase (SOD1) cause a subset of cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS). Transgenic…”
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Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis by Kostic, V, Gurney, M E, Deng, H X, Siddique, T, Epstein, C J, Przedborski, S

“…Familial amyotrophic lateral sclerosis has been linked in 15% of families to mutations in the gene encoding for copper-zinc superoxide dismutase (Cu/Zn-SOD), a…”
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Tau Phosphorylation at Serine 396 and Serine 404 by Human Recombinant Tau Protein Kinase II Inhibits Tau's Ability to Promote Microtubule Assembly by Evans, David B., Rank, Kenneth B., Bhattacharya, Keshab, Thomsen, Darrell R., Gurney, Mark E., Sharma, Satish K.

“…In Alzheimer's disease, hyperphosphorylated tau is an integral part of the neurofibrillary tangles that form within neuronal cell bodies and fails to promote…”
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Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis by GURNEY, M. E, FLECK, T. J, HIMES, C. S, HALL, E. D

“…Riluzole was tested in a dose-ranging study for preservation of motor function in a transgenic mouse model of familial ALS. The model is based on expression of…”
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A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis by DAL CANTO, M. C, GURNEY, M. E

“…About 15-20% of patients with familial amyotrophic lateral sclerosis (ALS) carry one of several missense mutations in the gene for Cu,Zn superoxide dismutase…”
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Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis by Liu, R, Althaus, J S, Ellerbrock, B R, Becker, D A, Gurney, M E

“…Mutations of the SOD1 gene encoding copper/zinc superoxide dismutase (CuZnSOD) cause an inherited form of amyotrophic lateral sclerosis. When expressed in…”
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The Golgi Apparatus of Spinal Cord Motor Neurons in Transgenic Mice Expressing Mutant Cu,Zn Superoxide Dismutase Becomes Fragmented in Early, Preclinical Stages of the Disease by Mourelatos, Zissimos, Gonatas, Nicholas K., Stieber, Anna, Gurney, Mark E., Mauro C. Dal Canto

“…Dominant mutations of the SOD1 gene encoding Cu,Zn superoxide dismutase have been found in members of certain families with familial amyotrophic lateral…”
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Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis by Facchinetti, F., Sasaki, M., Cutting, F.B., Macdonald, J.E., Reif, D., Beal, M.F., Huang, P.L., Dawson, T.M., Gurney, M.E., Dawson, V.L., Zhai, P.

“…A subset of familial cases of amyotrophic lateral sclerosis are linked to missense mutations in copper/zinc superoxide dismutase type 1. Patients with missense…”
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Intracellular Calcium Parallels Motoneuron Degeneration in SOD-1 Mutant Mice by Siklós, László, Engelhardt, József I, Alexianu, Maria E, Gurney, Mark E, Siddique, Teepu, Appel, Stanley H

“…Transgenic mice with Cu,Zn superoxide dismutase (SOD-1) mutations provide a unique model to examine altered Ca homeostasis in selectively vulnerable and…”
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