Search Results - "GUREVICH, V. V"

Biased GPCR signaling: Possible mechanisms and inherent limitations by Gurevich, Vsevolod V., Gurevich, Eugenia V.

“…G protein-coupled receptors (GPCRs) are targeted by about a third of clinically used drugs. Many GPCRs couple to more than one type of heterotrimeric G…”
Get full text

GPCRs and Signal Transducers: Interaction Stoichiometry by Gurevich, Vsevolod V., Gurevich, Eugenia V.

“…Until the late 1990s, class A G protein-coupled receptors (GPCRs) were believed to function as monomers. Indirect evidence that they might internalize or even…”
Get full text

Molecular Mechanisms of GPCR Signaling: A Structural Perspective by Gurevich, Vsevolod V, Gurevich, Eugenia V

“…G protein-coupled receptors (GPCRs) are cell surface receptors that respond to a wide variety of stimuli, from light, odorants, hormones, and neurotransmitters…”
Get full text

The structural basis of arrestin-mediated regulation of G-protein-coupled receptors by Gurevich, Vsevolod V, Gurevich, Eugenia V

“…The 4 mammalian arrestins serve as almost universal regulators of the largest known family of signaling proteins, G-protein-coupled receptors (GPCRs)…”
Get full text

GPCR Signaling Regulation: The Role of GRKs and Arrestins by Gurevich, Vsevolod V, Gurevich, Eugenia V

“…Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs) that respond to a wide variety of external stimuli. GPCRs-driven…”
Get full text

Plethora of functions packed into 45 kDa arrestins: biological implications and possible therapeutic strategies by Gurevich, Vsevolod V., Gurevich, Eugenia V.

“…Mammalian arrestins are a family of four highly homologous relatively small ~ 45 kDa proteins with surprisingly diverse functions. The most striking feature is…”
Get full text

Solo vs. Chorus: Monomers and Oligomers of Arrestin Proteins by Gurevich, Vsevolod V, Gurevich, Eugenia V

“…Three out of four subtypes of arrestin proteins expressed in mammals self-associate, each forming oligomers of a distinct kind. Monomers and oligomers have…”
Get full text

Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling by Seyedabadi, Mohammad, Gharghabi, Mehdi, Gurevich, Eugenia V., Gurevich, Vsevolod V.

“…Three classes of G-protein-coupled receptor (GPCR) partners – G proteins, GPCR kinases, and arrestins – preferentially bind active GPCRs. Our analysis suggests…”
Get full text

Receptor-Arrestin Interactions: The GPCR Perspective by Seyedabadi, Mohammad, Gharghabi, Mehdi, Gurevich, Eugenia V, Gurevich, Vsevolod V

“…Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a…”
Get full text

Structural basis of arrestin-3 activation and signaling by Chen, Qiuyan, Perry, Nicole A., Vishnivetskiy, Sergey A., Berndt, Sandra, Gilbert, Nathaniel C., Zhuo, Ya, Singh, Prashant K., Tholen, Jonas, Ohi, Melanie D., Gurevich, Eugenia V., Brautigam, Chad A., Klug, Candice S., Gurevich, Vsevolod V., Iverson, T. M.

“…A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol…”
Get full text

Arrestins: A Small Family of Multi-Functional Proteins by Gurevich, Vsevolod V

“…The first member of the arrestin family, visual arrestin-1, was discovered in the late 1970s. Later, the other three mammalian subtypes were identified and…”
Get full text

GPCR-dependent and -independent arrestin signaling by Gurevich, Vsevolod V., Gurevich, Eugenia V.

“…Several branches of arrestin-mediated signaling are initiated by G-protein-coupled receptor (GPCR)-bound arrestins.Numerous other signaling functions are…”
Get full text

The molecular acrobatics of arrestin activation by Gurevich, Vsevolod V, Gurevich, Eugenia V

“…Arrestin proteins play a key role in desensitizing G-protein-coupled receptors and re-directing their signaling to alternative pathways. The precise timing of…”
Get full text

GPCR monomers and oligomers: it takes all kinds by Gurevich, Vsevolod V, Gurevich, Eugenia V

“…Accumulating evidence of G-protein-coupled receptor (GPCR) oligomerization on the one hand and perfect functionality of monomeric receptors on the other…”
Get full text

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs by Gurevich, Eugenia V, Tesmer, John J G, Mushegian, Arcady, Gurevich, Vsevolod V

“…G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors…”
Get full text

G protein-coupled receptor kinases as regulators of dopamine receptor functions by Gurevich, Eugenia V., Gainetdinov, Raul R., Gurevich, Vsevolod V.

“…[Display omitted] Actions of the neurotransmitter dopamine in the brain are mediated by dopamine receptors that belong to the superfamily of G protein-coupled…”
Get full text

The structural basis of the arrestin binding to GPCRs by Gurevich, Vsevolod V., Gurevich, Eugenia V.

“…G protein-coupled receptors (GPCRs) are the largest family of signaling proteins targeted by more clinically used drugs than any other protein family. GPCR…”
Get full text

Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes by Indrischek, Henrike, Prohaska, Sonja J, Gurevich, Vsevolod V, Gurevich, Eugenia V, Stadler, Peter F

“…The cytosolic arrestin proteins mediate desensitization of activated G protein-coupled receptors (GPCRs) via competition with G proteins for the active…”
Get full text

Dynamic Nature of Proteins is Critically Important for Their Function: GPCRs and Signal Transducers by Gurevich, Vsevolod V., Gurevich, Eugenia V.

“…Proteins and their complexes in structures solved by X-ray crystallography or cryo-EM look rigid. While these structures yield very detailed information, they…”
Get full text

A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling by Gurevich, Vsevolod V, Gurevich, Eugenia V

“…cAMP signaling in the nucleus leads to the expression of immediate early genes in neurons and learning and memory. In this issue of , Martinez . found that…”
Get more information