Search Results - "GUOPING FENG"

Tmem119-EGFP and Tmem119-CreERT2 Transgenic Mice for Labeling and Manipulating Microglia by Kaiser, Tobias, Feng, Guoping

“…Microglia are specialized brain-resident macrophages with important functions in health and disease. To improve our understanding of these cells, the research…”
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Neurobiology of social behavior abnormalities in autism and Williams syndrome by Barak, Boaz, Feng, Guoping

“…The neurobiology of social behavior is highly complex and defects are present in several mental illnesses. Here Barak and Feng discuss neurobiological aspects…”
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Micro- and Nanotopography Sensitive Bacterial Attachment Mechanisms: A Review by Cheng, Yifan, Feng, Guoping, Moraru, Carmen I

“…Bacterial attachment to material surfaces can lead to the development of biofilms that cause severe economic and health problems. The outcome of bacterial…”
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Thalamic subnetworks as units of function by Roy, Dheeraj S., Zhang, Ying, Halassa, Michael M., Feng, Guoping

“…The thalamus engages in various functions including sensory processing, attention, decision making and memory. Classically, this diversity of function has been…”
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Multi-animal pose estimation, identification and tracking with DeepLabCut by Lauer, Jessy, Zhou, Mu, Ye, Shaokai, Menegas, William, Schneider, Steffen, Nath, Tanmay, Rahman, Mohammed Mostafizur, Di Santo, Valentina, Soberanes, Daniel, Feng, Guoping, Murthy, Venkatesh N., Lauder, George, Dulac, Catherine, Mathis, Mackenzie Weygandt, Mathis, Alexander

“…Estimating the pose of multiple animals is a challenging computer vision problem: frequent interactions cause occlusions and complicate the association of…”
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Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD by Chen, Qian, Deister, Christopher A., Gao, Xian, Guo, Baolin, Lynn-Jones, Taylor, Chen, Naiyan, Wells, Michael F., Liu, Runpeng, Goard, Michael J., Dimidschstein, Jordane, Feng, Shijing, Shi, Yiwu, Liao, Weiping, Lu, Zhonghua, Fishell, Gord, Moore, Christopher I., Feng, Guoping

“…Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis underlying…”
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AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset by Goertsen, David, Flytzanis, Nicholas C., Goeden, Nick, Chuapoco, Miguel R., Cummins, Alexander, Chen, Yijing, Fan, Yingying, Zhang, Qiangge, Sharma, Jitendra, Duan, Yangyang, Wang, Liping, Feng, Guoping, Chen, Yu, Ip, Nancy Y., Pickel, James, Gradinaru, Viviana

“…Genetic intervention is increasingly being explored as a therapeutic option for debilitating disorders of the central nervous system. The safety and efficacy…”
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Adult restoration of Shank3 expression rescues selective autistic-like phenotypes by Mei, Yuan, Monteiro, Patricia, Zhou, Yang, Kim, Jin-Ah, Gao, Xian, Fu, Zhanyan, Feng, Guoping

“…Re-expression of the Shank3 gene in adult mice results in improvements in synaptic protein composition and spine density in the striatum; Shank3 also rescues…”
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Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors by Burguière, Eric, Monteiro, Patrícia, Feng, Guoping, Graybiel, Ann M.

“…Dysfunctions in frontostriatal brain circuits have been implicated in neuropsychiatrie disorders, including those characterized by the presence of repetitive…”
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A transcription activator-like effector toolbox for genome engineering by Sanjana, Neville E, Cong, Le, Zhou, Yang, Cunniff, Margaret M, Feng, Guoping, Zhang, Feng

“…Transcription activator-like effectors (TALEs) are a class of naturally occurring DNA-binding proteins found in the plant pathogen Xanthomonas sp . The…”
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Striatal circuits, habits, and implications for obsessive–compulsive disorder by Burguière, Eric, Monteiro, Patricia, Mallet, Luc, Feng, Guoping, Graybiel, Ann M

“…Highlights • Involvement of corticostriatal circuits in OCD is receiving strong new experimental support. • This evidence is concordant with clinical evidence…”
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Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice by Guo, Baolin, Chen, Jing, Chen, Qian, Ren, Keke, Feng, Dayun, Mao, Honghui, Yao, Han, Yang, Jing, Liu, Haiying, Liu, Yingying, Jia, Fan, Qi, Chuchu, Lynn-Jones, Taylor, Hu, Hailan, Fu, Zhanyan, Feng, Guoping, Wang, Wenting, Wu, Shengxi

“…Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying neural mechanisms remain largely unclear. We demonstrate that…”
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Flow of cortical activity underlying a tactile decision in mice by Guo, Zengcai V, Li, Nuo, Huber, Daniel, Ophir, Eran, Gutnisky, Diego, Ting, Jonathan T, Feng, Guoping, Svoboda, Karel

“…Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of…”
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Comparative cellular analysis of motor cortex in human, marmoset and mouse by Bakken, Trygve E., Jorstad, Nikolas L., Hu, Qiwen, Lake, Blue B., Tian, Wei, Kalmbach, Brian E., Crow, Megan, Hodge, Rebecca D., Krienen, Fenna M., Sorensen, Staci A., Eggermont, Jeroen, Yao, Zizhen, Aevermann, Brian D., Aldridge, Andrew I., Bartlett, Anna, Bertagnolli, Darren, Casper, Tamara, Crichton, Kirsten, Daigle, Tanya L., Dalley, Rachel, Dembrow, Nikolai, Diep, Dinh, Ding, Song-Lin, Fang, Rongxin, Fischer, Stephan, Goldman, Melissa, Goldy, Jeff, Graybuck, Lucas T., Herb, Brian R., Hou, Xiaomeng, Kancherla, Jayaram, Kroll, Matthew, Lathia, Kanan, Li, Yang Eric, Liu, Christine S., Lucero, Jacinta D., Mahurkar, Anup, McMillen, Delissa, Miller, Jeremy A., Moussa, Marmar, Nery, Joseph R., Nicovich, Philip R., Niu, Sheng-Yong, Orvis, Joshua, Osteen, Julia K., Owen, Scott, Palmer, Carter R., Pham, Thanh, Plongthongkum, Nongluk, Poirion, Olivier, Reed, Nora M., Rimorin, Christine, Rivkin, Angeline, Romanow, William J., Sedeño-Cortés, Adriana E., Siletti, Kimberly, Somasundaram, Saroja, Sulc, Josef, Tieu, Michael, Torkelson, Amy, Tung, Herman, Wang, Xinxin, Xie, Fangming, Yanny, Anna Marie, Zhang, Renee, Ament, Seth A., Behrens, M. Margarita, Bravo, Hector Corrada, Chun, Jerold, Dobin, Alexander, Gillis, Jesse, Hertzano, Ronna, Hof, Patrick R., Höllt, Thomas, Horwitz, Gregory D., Keene, C. Dirk, Kharchenko, Peter V., Lelieveldt, Boudewijn P., Luo, Chongyuan, Mukamel, Eran A., Pinto-Duarte, António, Preissl, Sebastian, Regev, Aviv, Ren, Bing, Scheuermann, Richard H., Smith, Kimberly, Spain, William J., White, Owen R., Koch, Christof, Hawrylycz, Michael, Tasic, Bosiljka, Macosko, Evan Z., McCarroll, Steven A., Ting, Jonathan T., Zeng, Hongkui, Zhang, Kun, Feng, Guoping, Ecker, Joseph R., Linnarsson, Sten, Lein, Ed S.

“…The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals 1 . Here, using high-throughput…”
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Fast modulation of visual perception by basal forebrain cholinergic neurons by Pinto, Lucas, Goard, Michael J, Estandian, Daniel, Xu, Min, Kwan, Alex C, Lee, Seung-Hee, Harrison, Thomas C, Feng, Guoping, Dan, Yang

“…Cholinergic transmission from the basal forebrain provides neuromodulatory control over brain states such as wakefulness and sleep. Here the authors show that…”
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Shank3 mutant mice display autistic-like behaviours and striatal dysfunction by Peça, João, Feliciano, Cátia, Ting, Jonathan T., Wang, Wenting, Wells, Michael F., Venkatraman, Talaignair N., Lascola, Christopher D., Fu, Zhanyan, Feng, Guoping

“…Autism spectrum disorders (ASDs) comprise a range of disorders that share a core of neurobehavioural deficits characterized by widespread abnormalities in…”
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Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics by Ting, Jonathan T, Daigle, Tanya L, Chen, Qian, Feng, Guoping

“…The development of the living acute brain slice preparation for analyzing synaptic function roughly a half century ago was a pivotal achievement that greatly…”
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CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling by Platt, Randall J., Chen, Sidi, Zhou, Yang, Yim, Michael J., Swiech, Lukasz, Kempton, Hannah R., Dahlman, James E., Parnas, Oren, Eisenhaure, Thomas M., Jovanovic, Marko, Graham, Daniel B., Jhunjhunwala, Siddharth, Heidenreich, Matthias, Xavier, Ramnik J., Langer, Robert, Anderson, Daniel G., Hacohen, Nir, Regev, Aviv, Feng, Guoping, Sharp, Phillip A., Zhang, Feng

“…CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we…”
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Sustained axon regeneration induced by co-deletion of PTEN and SOCS3 by Sun, Fang, Park, Kevin K., Belin, Stephane, Wang, Dongqing, Lu, Tao, Chen, Gang, Zhang, Kang, Yeung, Cecil, Feng, Guoping, Yankner, Bruce A., He, Zhigang

“…Nerve regeneration at a distance Long-range extensive repair following nerve damage has been demonstrated in the peripheral nervous system, but such robust…”
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Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models by Orefice, Lauren L., Mosko, Jacqueline R., Morency, Danielle T., Wells, Michael F., Tasnim, Aniqa, Mozeika, Shawn M., Ye, Mengchen, Chirila, Anda M., Emanuel, Alan J., Rankin, Genelle, Fame, Ryann M., Lehtinen, Maria K., Feng, Guoping, Ginty, David D.

“…Somatosensory over-reactivity is common among patients with autism spectrum disorders (ASDs) and is hypothesized to contribute to core ASD behaviors. However,…”
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