Search Results - "GUNTHER, H. S"

Novel BCOR-MAML3 and ZC3H7B-BCOR Gene Fusions in Undifferentiated Small Blue Round Cell Sarcomas by Specht, Katja, Zhang, Lei, Sung, Yun-Shao, Nucci, Marisa, Dry, Sarah, Vaiyapuri, Sumathi, Richter, Gunther H.S, Fletcher, Christopher D.M, Antonescu, Cristina R

“…Small blue round cell tumors (SBRCTs) are a heterogenous group of tumors that are difficult to diagnose because of overlapping morphologic,…”
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Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged ewing sarcomas: Further evidence toward distinct pathologic entities by Specht, Katja, Sung, Yun-Shao, Zhang, Lei, Richter, Günther H. S., Fletcher, Christopher D., Antonescu, Cristina R.

“…Round cell sarcomas harboring CIC‐DUX4 fusions have recently been described as highly aggressive soft tissue tumors of children and young adults. Due to…”
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Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis by Schmidt, Oxana, Nehls, Nadja, Prexler, Carolin, von Heyking, Kristina, Groll, Tanja, Pardon, Katharina, Garcia, Heathcliff D, Hensel, Tim, Gürgen, Dennis, Henssen, Anton G, Eggert, Angelika, Steiger, Katja, Burdach, Stefan, Richter, Günther H S

“…Histone acetylation and deacetylation seem processes involved in the pathogenesis of Ewing sarcoma (EwS). Here histone deacetylases (HDAC) class I were…”
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Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria by Günther, H S, Schmidt, N O, Phillips, H S, Kemming, D, Kharbanda, S, Soriano, R, Modrusan, Z, Meissner, H, Westphal, M, Lamszus, K

“…Tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We…”
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EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation by Richter, Günther H.S, Plehm, Stephanie, Fasan, Annette, Rössler, Sabine, Unland, Rebekka, Bennani-Baiti, Idriss M, Hotfilder, Marc, Löwel, Diana, von Luettichau, Irene, Mossbrugger, Ilona, Quintanilla-Martinez, Leticia, Kovar, Heinrich, Staege, Martin S, Müller-Tidow, Carsten, Burdach, Stefan

“…Ewing tumors (ET) are highly malignant, localized in bone or soft tissue, and are molecularly defined by ews/ets translocations. DNA microarray analysis…”
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Correction to: Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis by Schmidt, Oxana, Nehls, Nadja, Prexler, Carolin, von Heyking, Kristina, Groll, Tanja, Pardon, Katharina, Garcia, Heathcliff D, Hensel, Tim, Gürgen, Dennis, Henssen, Anton G, Eggert, Angelika, Steiger, Katja, Burdach, Stefan, Richter, Günther H S

“…An amendment to this paper has been published and can be accessed via the original article…”
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Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A02:01-specific allorestricted T cell receptor transgenic T cells by Thiel, Uwe, Schober, Sebastian J., Einspieler, Ingo, Kirschner, Andreas, Thiede, Melanie, Schirmer, David, Gall, Katja, Blaeschke, Franziska, Schmidt, Oxana, Jabar, Susanne, Ranft, Andreas, Alba Rubío, Rebeca, Dirksen, Uta, Grunewald, Thomas G. P., Sorensen, Poul H., Richter, Günther H. S., von Lüttichau, Irene Teichert, Busch, Dirk H., Burdach, Stefan E. G.

“…Background: Chondromodulin-I (CHM1) sustains malignancy in Ewing sarcoma (ES). Refractory ES carries a dismal prognosis and patients with bone marrow (BM)…”
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The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma by Heyking, Kristina, Calzada‐Wack, Julia, Göllner, Stefanie, Neff, Frauke, Schmidt, Oxana, Hensel, Tim, Schirmer, David, Fasan, Annette, Esposito, Irene, Müller‐Tidow, Carsten, Sorensen, Poul H., Burdach, Stefan, Richter, Günther H. S.

“…Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS–ETS translocations and early metastasis to lung…”
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Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo by Kirschner, Andreas, Thiede, Melanie, Grünewald, Thomas G. P., Alba Rubio, Rebeca, Richter, Günther H. S., Kirchner, Thomas, Busch, Dirk H., Burdach, Stefan, Thiel, Uwe

“…Pregnancy-associated plasma protein-A (PAPPA), also known as pappalysin, is a member of the insulin-like growth factor (IGF) family. PAPPA acts as a protease,…”
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Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system by Unland, Rebekka, Kerl, Kornelius, Schlosser, Sabrina, Farwick, Nicole, Plagemann, Tanja, Lechtape, Birigit, Clifford, Steven C., Kreth, Jonas H., Gerss, Joachim, Mühlisch, Jörg, Richter, Günther H. S., Hasselblatt, Martin, Frühwald, Michael C.

“…Epigenetic alterations are common events in cancer. Using a genome wide methylation screen (Restriction Landmark Genomic Scanning—RLGS) we identified the gene…”
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G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1 by Richter, Günther HS, Fasan, Annette, Hauer, Kristina, Grunewald, Thomas GP, Berns, Colette, Rössler, Sabine, Naumann, Ivonne, Staege, Martin S., Fulda, Simone, Esposito, Irene, Burdach, Stefan

“…Metastatic spread in Ewing sarcomas (ES) is frequent and haematogenous. G‐protein coupled receptor 64 (GPR64), an orphan receptor with normal expression…”
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The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report by Kager, Leo, Whelan, Jeremy, Dirksen, Uta, Hassan, Bass, Anninga, Jakob, Bennister, Lindsey, Bovée, Judith V M G, Brennan, Bernadette, Broto, Javier M, Brugières, Laurence, Cleton-Jansen, Anne-Marie, Copland, Christopher, Dutour, Aurélie, Fagioli, Franca, Ferrari, Stefano, Fiocco, Marta, Fleuren, Emmy, Gaspar, Nathalie, Gelderblom, Hans, Gerrand, Craig, Gerß, Joachim, Gonzato, Ornella, van der Graaf, Winette, Hecker-Nolting, Stefanie, Herrero-Martín, David, Klco-Brosius, Stephanie, Kovar, Heinrich, Ladenstein, Ruth, Lancia, Carlo, LeDeley, Marie-Cecile, McCabe, Martin G, Metzler, Markus, Myklebost, Ola, Nathrath, Michaela, Picci, Piero, Potratz, Jenny, Redini, Françoise, Richter, Günther H S, Reinke, Denise, Rutkowski, Piotr, Scotlandi, Katia, Strauss, Sandra, Thomas, David, Tirado, Oscar M, Tirode, Franck, Vassal, Gilles, Bielack, Stefan S

“…This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at…”
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MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress by Sipol, Alexandra, Hameister, Erik, Xue, Busheng, Hofstetter, Julia, Barenboim, Maxim, Öllinger, Rupert, Jain, Gaurav, Prexler, Carolin, Rubio, Rebeca Alba, Baldauf, Michaela C., Franchina, Davide G., Petry, Andreas, Schmäh, Juliane, Thiel, Uwe, Görlach, Agnes, Cario, Gunnar, Brenner, Dirk, Richter, Günther H.S., Grünewald, Thomas G.P., Rad, Roland, Wolf, Elmar, Ruland, Jürgen, Sorensen, Poul H., Burdach, Stefan E.G.

“…Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced…”
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Matrix mineralization controls gene expression in osteoblastic cells by Wischmann, Johannes, Lenze, Florian, Thiel, Antonia, Bookbinder, Sakina, Querido, William, Schmidt, Oxana, Burgkart, Rainer, von Eisenhart-Rothe, Rüdiger, Richter, Günther H.S., Pleshko, Nancy, Mayer-Kuckuk, Philipp

“…Osteoblasts are adherent cells, and under physiological conditions they attach to both mineralized and non-mineralized osseous surfaces. However, how exactly…”
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DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma by HAUER, Kristina, CALZADA-WACK, Julia, RICHTER, Günther H. S, STEIGER, Katja, GRUNEWALD, Thomas G. P, BAUMHOER, Daniel, PLEHM, Stephanie, BUCH, Thorsten, DA COSTA, Olivia Prazeres, ESPOSITO, Irene, BURDACH, Stefan

“…Ewing sarcoma, an osteolytic malignancy that mainly affects children and young adults, is characterized by early metastasis to lung and bone. In this study, we…”
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First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications by Miller, Isabella V., Raposo, Graca, Welsch, Ulrich, Prazeres da Costa, Olivia, Thiel, Uwe, Lebar, Maria, Maurer, Martina, Bender, Hans-Ulrich, von Luettichau, Irene, Richter, Günther H. S., Burdach, Stefan, Grunewald, Thomas G. P.

“…Background Information Exosomes are small RNA‐ and protein‐containing extracellular vesicles (EVs) that are thought to mediate hetero‐ and homotypic…”
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Transgenic antigen-specific, HLA-A02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity by Schirmer, David, Grünewald, Thomas G. P., Klar, Richard, Schmidt, Oxana, Wohlleber, Dirk, Rubío, Rebeca Alba, Uckert, Wolfgang, Thiel, Uwe, Bohne, Felix, Busch, Dirk H., Krackhardt, Angela M., Burdach, Stefan, Richter, Günther H. S.

“…Pediatric cancers, including Ewing sarcoma (ES), are only weakly immunogenic and the tumor-patients' immune system often is devoid of effector T cells for…”
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Heparin-Treated, v-myc-Transformed Chicken Heart Mesenchymal Cells Assume a Normal Morphology but are Hypersensitive to Epidermal Growth Factor (EGF) and Brain Fibroblast Growth Factor (bFGF); Cells Transformed by the V-Ha-ras Oncogene are Refractory to EGF and bFGF but are Hypersensitive to Insulin-Like Growth Factors by Balk, Samuel D., Riley, Thomas M., Gunther, Harriet S., Morisi, Andrea

“…Chicken heart mesenchymal cells do not proliferate in culture medium containing heat-defibrinogenated plasma but proliferate briskly when incubated with…”
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Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens by Kirschner, Andreas, Thiede, Melanie, Blaeschke, Franziska, Richter, Günther H S, Gerke, Julia S, Baldauf, Michaela C, Grünewald, Thomas G P, Busch, Dirk H, Burdach, Stefan, Thiel, Uwe

“…Autologous as well as allogeneic CD8+ T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive…”
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Phorbol 12-myristate 13-acetate, Ionomycin or Ouabain, and Raised Extracellular Magnesium Induce Proliferation of Chicken Heart Mesenchymal Cells by Balk, Samuel D., Morisi, Andrea, Gunther, Harriet S.

“…Cultured chicken heart mesenchymal cells are proliferatively quiescent at low densities in medium containing plasma at 10%. Mitogenic hormones like epidermal…”
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