Search Results - "GUNDLACH, A. L"

Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat by Ma, S, Bonaventure, P, Ferraro, T, Shen, P.-J, Burazin, T.C.D, Bathgate, R.A.D, Liu, C, Tregear, G.W, Sutton, S.W, Gundlach, A.L

“…Abstract Relaxin-3 (RLX3) is a newly identified member of the relaxin/insulin peptide family that is highly conserved across a range of species from fish to…”
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Relaxin‐3 null mutation mice display a circadian hypoactivity phenotype by Smith, C. M., Hosken, I. T., Sutton, S. W., Lawrence, A. J., Gundlach, A. L.

“…Characterizing the neurocircuits and neurotransmitters that underlie arousal and circadian sleep/wake patterns is an important goal of neuroscience research,…”
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Relaxin‐3 inputs target hippocampal interneurons and deletion of hilar relaxin‐3 receptors in “floxed‐RXFP3” mice impairs spatial memory by Haidar, M., Guèvremont, G., Zhang, C., Bathgate, R.A.D., Timofeeva, E., Smith, C.M., Gundlach, A.L.

“…ABSTRACT Hippocampus is innervated by γ‐aminobutyric acid (GABA) “projection” neurons of the nucleus incertus (NI), including a population expressing the…”
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Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear by Pereira, C.W., Santos, F.N., Sánchez-Pérez, A.M., Otero-García, M., Marchioro, M., Ma, S., Gundlach, A.L., Olucha-Bordonau, F.E.

“…•The pontine n. incertus role in fear conditioning and extinction has been studied.•An important projection from the n. incertus to amygdala nuclei has been…”
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Anxiogenic drug administration and elevated plus-maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus by Lawther, A.J, Clissold, M.L, Ma, S, Kent, S, Lowry, C.A, Gundlach, A.L, Hale, M.W

“…Highlights • Anxiogenic stimuli activate serotonergic neurons in the dorsal raphe nucleus and relaxin-3 neurons in the nucleus incertus. • Activation of…”
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Relaxin‐3 receptor (Rxfp3) gene deletion reduces operant sucrose‐ but not alcohol‐responding in mice by Walker, A. W., Smith, C. M., Gundlach, A. L., Lawrence, A. J.

“…The pervasive use of refined sugars in highly accessible, palatable foods and persistent exposure to reinforcing food‐associated cues has contributed to…”
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Leucine-rich repeat-containing G-protein-coupled receptor 8 in the rat brain: Enrichment in thalamic neurons and their efferent projections by Sedaghat, K, Shen, P.-J, Finkelstein, D.I, Henderson, J.M, Gundlach, A.L

“…Abstract Leucine-rich repeat-containing G-protein-coupled receptor 8 (LGR8; also classified as relaxin family peptide 2 receptor; RXFP2) has been identified as…”
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Ascending Control of Arousal and Motivation: Role of Nucleus Incertus and its Peptide Neuromodulators in Behavioural Responses to Stress by Ma, S., Gundlach, A. L.

“…Arousal is a process that involves the activation of ascending neural pathways originating in the rostral pons that project to the forebrain through the…”
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Comparative localization of leucine-rich repeat-containing G-protein-coupled receptor-7 (RXFP1) mRNA and [33P]-relaxin binding sites in rat brain: Restricted somatic co-expression a clue to relaxin action? by Ma, S., Shen, P.-J., Burazin, T.C.D., Tregear, G.W., Gundlach, A.L.

“…Relaxin is a polypeptide hormone with established actions associated with reproductive physiology, but until recently the precise nature of the relaxin…”
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[ 125I]-Galanin binding in brain of wildtype, and galanin- and GalR1-knockout mice: Strain and species differences in GalR1 density and distribution by Jungnickel, S.R.-F., Gundlach, A.L.

“…Widespread production of knockout and transgenic mice has led to an increased use of mice as animal models for studies of normal- and patho-physiology. Hence,…”
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Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation by Fu, P, Shen, P-J, Zhao, C-X, Scott, D J, Samuel, C S, Wade, J D, Tregear, G W, Bathgate, R A D, Gundlach, A L

“…Leucine-rich repeat-containing G-protein-coupled receptor 8 (LGR8, or RXFP2) is a member of the type C leucine-rich repeat-containing G protein-coupled…”
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Atrial natriuretic peptide expression is increased in rat cerebral cortex following spreading depression: Possible contribution to SD-induced neuroprotection by WIGGINS, A. K, SHEN, P.-J, GUNDLACH, A. L

“…Cortical spreading depression (CSD) is characterised by slowly propagating waves of cellular depolarization and depression and involves transient changes in…”
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Galanin treatment offsets the inhibition of bone formation and downregulates the increase in mouse calvarial expression of TNFα and GalR2 mRNA induced by chronic daily injections of an injurious vehicle by McDonald, A.C, Schuijers, J.A, Gundlach, A.L, Grills, B.L

“…Abstract We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however,…”
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Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus by Ganella, D E, Callander, G E, Ma, S, Bye, C R, Gundlach, A L, Bathgate, R A D

“…Relaxin-3 is a neuropeptide that is abundantly expressed by discrete brainstem neuron populations that broadly innervate forebrain areas rich in the relaxin-3…”
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Induction of galanin receptor‐1 (GalR1) expression in external granule cell layer of post‐natal mouse cerebellum by Jungnickel, S. R.‐F., Yao, M., Shen, P.‐J., Gundlach, A. L.

“…Galanin is a modulator of fast transmission in adult brain and recent evidence suggests that it also acts as a trophic factor during neurogenesis and neural…”
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Nucleus incertus ablation disrupted conspecific recognition and modified immediate early gene expression patterns in ‘social brain’ circuits of rats by García-Díaz, C., Sánchez-Catalán, M.J., Castro-Salazar, E., García-Avilés, A., Albert-Gascó, H., Sánchez-Sarasúa de la Bárcena, S., Sánchez-Pérez, A.M., Gundlach, A.L., Olucha-Bordonau, F.E.

“…[Display omitted] •NI lesion did not affect discrimination between conspecific and object.•NI lesion impaired increased interaction to the novel vs familiar…”
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Relaxin-3 mRNA levels in nucleus incertus correlate with alcohol and sucrose intake in rats by Ryan, P.J, Krstew, E.V, Sarwar, M, Gundlach, A.L, Lawrence, A.J

“…Abstract Background Chronic alcohol intake produces multiple neuroadaptive changes, including up- and down-regulation of neuropeptides and receptors. There are…”
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Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine by Largent, B L, Gundlach, A L, Snyder, S H

“…The benzomorphan opioid, SKF 10,047, is the prototypical agonist for the sigma receptor. In this study, pharmacological and autoradiographic analyses reveal…”
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Regulation by Osmotic Stimuli of Galanin-R1 Receptor Expression in Magnocellular Neurones of the Paraventricular and Supraoptic Nuclei of the Rat by Burazin, T. C. D., Larm, J. A., Gundlach, A. L.

“…Neurones of the supraoptic nucleus (SON) and the magnocellular and parvocellular divisions ofthe paraventricular nucleus (PVN) express galanin and…”
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Prolonged Induction of Neuronal NOS Expression and Activity Following Cortical Spreading Depression (SD): Implications for SD- and NO-Mediated Neuroprotection by Shen, Pei-Juan, Gundlach, Andrew L.

“…Cortical spreading depression (CSD) is associated with various short- and long-term physiological and neurochemical changes and has been shown to confer an…”
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