Search Results - "GUMMULURU, Suryaram"

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses by Jalloh, Sallieu, Olejnik, Judith, Berrigan, Jacob, Nisa, Annuurun, Suder, Ellen L, Akiyama, Hisashi, Lei, Maohua, Ramaswamy, Sita, Tyagi, Sanjay, Bushkin, Yuri, Mühlberger, Elke, Gummuluru, Suryaram

“…Exacerbated and persistent innate immune response marked by pro-inflammatory cytokine expression is thought to be a major driver of chronic COVID-19 pathology…”
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HIV-1 Persistence and Chronic Induction of Innate Immune Responses in Macrophages by Akiyama, Hisashi, Gummuluru, Suryaram

“…A hallmark of HIV-1 infection is chronic inflammation, which plays a significant role in disease pathogenesis. Acute HIV infection induces robust inflammatory…”
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Illuminating the Role of Vpr in HIV Infection of Myeloid Cells by Nodder, Sarah Beth, Gummuluru, Suryaram

“…Vpr is a 14 kDa accessory protein conserved amongst extant primate lentiviruses that is required for virus replication . Although many functions have been…”
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CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV‑2 by Amraei, Razie, Yin, Wenqing, Napoleon, Marc A, Suder, Ellen L, Berrigan, Jacob, Zhao, Qing, Olejnik, Judith, Chandler, Kevin Brown, Xia, Chaoshuang, Feldman, Jared, Hauser, Blake M, Caradonna, Timothy M, Schmidt, Aaron G, Gummuluru, Suryaram, Mühlberger, Elke, Chitalia, Vipul, Costello, Catherine E, Rahimi, Nader

“…As the COVID-19 pandemic continues to spread, investigating the processes underlying the interactions between SARS-CoV-2 and its hosts is of high importance…”
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HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction by Akiyama, Hisashi, Miller, Caitlin M., Ettinger, Chelsea R., Belkina, Anna C., Snyder-Cappione, Jennifer E., Gummuluru, Suryaram

“…Low levels of type I interferon (IFN-I) are thought to be a driving force for immune activation and T-cell exhaustion in HIV-1 infected individuals on…”
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Immature Dendritic Cell-Derived Exosomes Can Mediate HIV-1 Trans Infection by Wiley, Rebecca D., Gummuluru, Suryaram

“…Immature dendritic cells (DCs) capture HIV type 1 (HIV-1) and can transmit captured virus particles to T cells. In this report, we show that HIV-1 particles…”
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Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon by Akiyama, Hisashi, Ramirez, Nora-Guadalupe Pina, Gibson, Gregory, Kline, Christopher, Watkins, Simon, Ambrose, Zandrea, Gummuluru, Suryaram

“…A hallmark of human immunodeficiency virus type 1 (HIV-1) infection is chronic immune activation concomitant with type I interferon (IFN) production. Although…”
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Membrane-wrapped nanoparticles probe divergent roles of GM3 and phosphatidylserine in lipid-mediated viral entry pathways by Xu, Fangda, Bandara, Asanga, Akiyama, Hisashi, Eshaghi, Behnaz, Stelter, David, Keyes, Tom, Straub, John E., Gummuluru, Suryaram, Reinhard, Björn M.

“…Gold nanoparticles (NPs) wrapped in a membrane can be utilized as artificial virus nanoparticles (AVNs) that combine the large nonblinking or bleaching optical…”
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HIV-1 incorporation of host-cell–derived glycosphingolipid GM3 allows for capture by mature dendritic cells by Puryear, Wendy Blay, Yu, Xinwei, Ramirez, Nora P, Reinhard, Björn M, Gummuluru, Suryaram

“…The interaction between HIV and dendritic cells (DCs) is an important early event in HIV-1 pathogenesis that leads to efficient viral dissemination. Here we…”
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Hsp70-Bag3 Interactions Regulate Cancer-Related Signaling Networks by COLVIN, Teresa A, GABAI, Vladimir L, GARCIA-MARCOS, Mikel, XIAOKAI LI, YOUNG, Z. T, RAUCH, Jennifer N, GESTWICKI, Jason E, TAKAYAMA, Shinichi, SHERMAN, Michael Y, JIANLIN GONG, CALDERWOOD, Stuart K, HU LI, GUMMULURU, Suryaram, MATCHUK, Olga N, SMIRNOVA, Svetlana G, ORLOVA, Nina V, ZAMULAEVA, Irina A

“…Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here, we report that Bag3 interacts with the SH3…”
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CD169-mediated trafficking of HIV to plasma membrane invaginations in dendritic cells attenuates efficacy of anti-gp120 broadly neutralizing antibodies by Akiyama, Hisashi, Ramirez, Nora-Guadalupe Pina, Gudheti, Manasa V, Gummuluru, Suryaram

“…Myeloid dendritic cells (DCs) can capture HIV-1 via the receptor CD169/Siglec-1 that binds to the ganglioside, GM3, in the virus particle membrane. In turn,…”
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Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169 by Puryear, Wendy Blay, Akiyama, Hisashi, Geer, Suzanne D, Ramirez, Nora P, Yu, Xinwei, Reinhard, Björn M, Gummuluru, Suryaram

“…Human immunodeficiency virus type 1 (HIV-1) interactions with myeloid dendritic cells (DCs) can result in virus dissemination to CD4⁺ T cells via a trans…”
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Deamination-Independent Inhibition of Hepatitis B Virus Reverse Transcription by APOBEC3G by NGUYEN, David H, GUMMULURU, Suryaram, JIANMING HU

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Anti‐SARS‐CoV‐2 activity of targeted kinase inhibitors: Repurposing clinically available drugs for COVID‐19 therapy by Boytz, RuthMabel, Słabicki, Mikołaj, Ramaswamy, Sita, Patten, J. J., Zou, Charles, Meng, Chengcheng, Hurst, Brett L., Wang, Jinhua, Nowak, Radosław P., Yang, Priscilla L., Sattler, Martin, Stone, Richard M., Griffin, James D., Gray, Nathanael S., Gummuluru, Suryaram, Davey, Robert A., Weisberg, Ellen

“…Coronavirus disease 2019 (COVID‐19) remains a major public health concern, and vaccine unavailability, hesitancy, or failure underscore the need for discovery…”
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Strength of T cell signaling regulates HIV-1 replication and establishment of latency by Gagne, Matthew, Michaels, Daniel, Schiralli Lester, Gillian M, Gummuluru, Suryaram, Wong, Wilson W, Henderson, Andrew J

“…A major barrier to curing HIV-1 is the long-lived latent reservoir that supports re-emergence of HIV-1 upon treatment interruption. Targeting this reservoir…”
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Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells by Yu, Xinwei, Feizpour, Amin, Ramirez, Nora-Guadalupe P., Wu, Linxi, Akiyama, Hisashi, Xu, Fangda, Gummuluru, Suryaram, Reinhard, Björn M.

“…Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions…”
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Stiffness of HIV‐1 Mimicking Polymer Nanoparticles Modulates Ganglioside‐Mediated Cellular Uptake and Trafficking by Eshaghi, Behnaz, Alsharif, Nourin, An, Xingda, Akiyama, Hisashi, Brown, Keith A., Gummuluru, Suryaram, Reinhard, Björn M.

“…The monosialodihexosylganglioside, GM3, and its binding to CD169 (Siglec‐1) have been indicated as key factors in the glycoprotein‐independent sequestration of…”
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Functional Interplay Between Murine Leukemia Virus Glycogag, Serinc5, and Surface Glycoprotein Governs Virus Entry, with Opposite Effects on Gammaretroviral and Ebolavirus Glycoproteins by Ahi, Yadvinder S, Zhang, Shu, Thappeta, Yashna, Denman, Audrey, Feizpour, Amin, Gummuluru, Suryaram, Reinhard, Bjoern, Muriaux, Delphine, Fivash, Matthew J, Rein, Alan

“…Gammaretroviruses, such as murine leukemia viruses (MLVs), encode, in addition to the canonical Gag, Pol, and Env proteins that will form progeny virus…”
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Plasmonic Enhancement of Selective Photonic Virus Inactivation by Nazari, Mina, Xi, Min, Lerch, Sarah, Alizadeh, M. H., Ettinger, Chelsea, Akiyama, Hisashi, Gillespie, Christopher, Gummuluru, Suryaram, Erramilli, Shyamsunder, Reinhard, Björn M.

“…Femtosecond (fs) pulsed laser irradiation techniques have attracted interest as a photonic approach for the selective inactivation of virus contaminations in…”
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Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture by Ruedas, John B, Ladner, Jason T, Ettinger, Chelsea R, Gummuluru, Suryaram, Palacios, Gustavo, Connor, John H

“…Ebolaviruses have a surface glycoprotein (GP ) that is required for virus attachment and entry into cells. Mutations affecting GP functions can alter virus…”
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