Search Results - "GULLICK, W. J"

The epidermal growth factor receptor family by Bazley, L A, Gullick, W J

“…The epidermal growth factor receptor family consists of four receptor genes and at least 11 ligands, several of which are produced in different protein forms…”
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Mutations of the epidermal growth factor receptor in non-small cell lung cancer – Search and destroy by Chan, S.K., Gullick, W.J., Hill, M.E.

“…The targeting of the ATP binding pocket of the epidermal growth factor receptor (EGFR) tyrosine kinase, by the small molecule drugs gefitinib and erlotinib,…”
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The Type 1 growth factor receptors and their ligands considered as a complex system by Gullick, W J

“…The Type 1 family of growth factors and their receptors play an important role in normal development, wound healing and in diseases such as cancer. The…”
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Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers by Gullick, W J

“…This chapter reviews briefly the prevalence of overexpression of the epidermal growth factor receptor in human cancers. In addition, it examines the mechanisms…”
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Assessment of HER2 status in breast cancer: why, when and how? by Dowsett, M, Cooke, T, Ellis, I, Gullick, W.J, Gusterson, B, Mallon, E, Walker, R

“…Human epidermal growth factor receptor 2 (HER2) is overexpressed, usually as a result of HER2 proto-oncogene amplification, in 20–30% of breast cancers. A…”
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Characterization of the cell membrane-associated products of the Neuregulin 4 gene by Hayes, N V L, Newsam, R J, Baines, A J, Gullick, W J

“…The NRG4 gene is a member of a family of four genes that encode a class of epidermal growth factors. This gene has been reported to express a protein…”
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Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway by CLARKE, K, SMITH, K, GULLICK, W. J, HARRIS, A. L

“…Over-expression of truncated epidermal growth factor receptor (EGFR) occurs in a variety of malignancies including glioblastoma multiforme, breast and lung…”
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Type 1 growth factor receptor expression in node positive breast cancer: adverse prognostic significance of c-erbB-4 by Lodge, A J, Anderson, J J, Gullick, W J, Haugk, B, Leonard, R C F, Angus, B

“…Background: There is a clear need to define biological markers that will predict the response to treatment in breast cancer, and several recent studies suggest…”
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Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity by MCCLELLAND, C. M, GULLICK, W. J

“…Epidermal growth factor receptor is a potential target for cancer treatment and new small-molecule tyrosine kinase inhibitor drugs have been designed to…”
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The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer by Saloman, D S, Bianco, C, Ebert, A D, Khan, N I, De Santis, M, Normanno, N, Wechselberger, C, Seno, M, Williams, K, Sanicola, M, Foley, S, Gullick, W J, Persico, G

“…The EGF-CFC gene family encodes a group of structurally related proteins that serve as important competence factors during early embryogenesis in Xenopus,…”
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c-erbB-4 protein expression in human breast cancer by KEW, T. Y, BELL, J. A, PINDER, S. E, DENLEY, H, SRINIVASAN, R, GULLICK, W. J, NICHOLSON, R. I, BLAMEY, R. W, ELLIS, I. O

“…The Type 1 family of growth factor receptors includes epidermal growth factor receptor (EGFR), c-erbB-2, c-erbB-3 and c-erbB-4. Overexpression of the first two…”
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Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types by Srinivasan, Radhika, Poulsom, Richard, Hurst, Helen C., Gullick, William J.

“…The c‐erbB‐4/HER4 receptor belongs to the family of the type I growth factor receptors. Mouse monoclonal antibodies have been raised to the cytoplasmic domain…”
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c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer by KNOWLDEN, J. M, GEE, J. M. W, SEERY, L. T, FARROW, L, GULLICK, W. J, ELLIS, I. O, BLAMEY, R. W, ROBERTSON, J. F. R, NICHOLSON, R. I

“…We examined c-erbB3 and c-erbB4 mRNA expression in 47 primary breast cancer samples by simultaneous RT-PCR and have investigated correlations between these…”
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Clinical value of epidermal growth factor receptor expression in primary breast cancer by Rampaul, R S, Pinder, S E, Nicholson, R I, Gullick, W J, Robertson, J F, Ellis, I O

“…EGFR expression in primary breast cancer has been extensively investigated for its prognostic and predictive value. However overall there is no consensus on…”
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Expression of the ERBB3 gene product in breast cancer by LEMOINE, N. R, BARNES, D. M, HOLLYWOOD, D. P, HUGHES, C. M, SMITH, P, DUBLIN, E, PRIGENT, S. A, GULLICK, W. J, HURST, H. C

“…Abnormalities of the EGF receptor and/or the related ERBB2 receptor occur in a significant proportion of cases of human breast cancer and are important…”
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eph, the largest known family of putative growth factor receptors by TUZI, N. L, GULLICK, W. J

“…(DBO)…”
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Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 Growth Factor Receptors and Their Ligands, Neuregulin-1 α, Neuregulin-1 β, and Betacellulin, in Normal Endometrium and Endometrial Cancer by SRINIVASAN, R, BENTON, E, MCCORMICK, F, THOMAS, H, GULLICK, W. J

“…The objective of this study was to determine the immunohistochemical expression of the c-erbB-3 and c-erbB-4 growth factor receptors and their principal…”
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c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes by GULLICK, W. J, LOVE, S. B, WRIGHT, C, BARNES, D. M, GUSTERSON, B, HARRIS, A. L, ALTMAN, D. G

“…The c-erbB-2 gene is overexpressed in about 20% of human breast cancers. Four hundred and eighty-three cases previously examined by immunohistochemical…”
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c-erbB-2 oncoprotein expression in primary and advanced breast cancer by LOVEKIN, C, ELLIS, I. O, LOCKER, A, ROBERTSON, J. F. R, BELL, J, NICHOLSON, R, GULLICK, W. J, ELSTON, C. W, BLAMEY, R. W

“…Immunoreactivity for c-erbB-2 oncogene product expression has been investigated in patients with breast cancer using the polyclonal antibody 21N. Three series…”
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C-erbB-3 in human breast carcinoma: expression and relation to prognosis and established prognostic indicators by Travis, A, Pinder, S E, Robertson, J F, Bell, J A, Wencyk, P, Gullick, W J, Nicholson, R I, Poller, D N, Blamey, R W, Elston, C W, Ellis, I O

“…A series of 346 patients with primary operable breast cancer and a series of 145 patients with advanced breast cancer were investigated for c-erbB-3 protein…”
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