Search Results - "GUIRAKHOO, F"

Safety and Efficacy of Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine Formulations in Nonhuman Primates by GUIRAKHOO, F, PUGACHEV, K, BROWN, N, BRANDLER, S, FOURNIER, C, BARRERE, B, RIZVI, F, TRAVASSOS, A, NICHOLS, R, TRENT, D, MONATH, T, ZHANG, Z, MYERS, G, LEVENBOOK, I, DRAPER, K, LANG, J, OCRAN, S, MITCHELL, F, PARSONS, M

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Development of a Zika vaccine using a novel MVA-VLP platform by Guirakhoo, F, Domi, A, McCurley, N, Robinson, H

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Construction, Safety, and Immunogenicity in Nonhuman Primates of a Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine by Guirakhoo, F, Arroyo, J, Pugachev, K V, Miller, C, Zhang, Z X, Weltzin, R, Georgakopoulos, K, Catalan, J, Ocran, S, Soike, K, Ratterree, M, Monath, T P

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Viremia and Immunogenicity in Nonhuman Primates of a Tetravalent Yellow Fever–Dengue Chimeric Vaccine: Genetic Reconstructions, Dose Adjustment, and Antibody Responses against Wild-type Dengue Virus Isolates by Guirakhoo, F., Pugachev, K., Arroyo, J., Miller, C., Zhang, Z.-X., Weltzin, R., Georgakopoulos, K., Catalan, J., Ocran, S., Draper, K., Monath, T.P.

“…Chimeric yellow fever (YF)–dengue (DEN) viruses (ChimeriVax–DEN) were reconstructed to correct amino acid substitutions within the envelope genes of original…”
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Recombinant Chimeric Yellow Fever-Dengue Type 2 Virus Is Immunogenic and Protective in Nonhuman Primates by Guirakhoo, F, Weltzin, R, Chambers, T J, Zhang, Z X, Soike, K, Ratterree, M, Arroyo, J, Georgakopoulos, K, Catalan, J, Monath, T P

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Chimeric Yellow Fever Virus 17D-Japanese Encephalitis Virus Vaccine: Dose-Response Effectiveness and Extended Safety Testing in Rhesus Monkeys by Monath, T P, Levenbook, I, Soike, K, Zhang, Z X, Ratterree, M, Draper, K, Barrett, A D, Nichols, R, Weltzin, R, Arroyo, J, Guirakhoo, F

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Molecular Basis for Attenuation of Neurovirulence of a Yellow Fever Virus/Japanese Encephalitis Virus Chimera Vaccine (ChimeriVax-JE) by Arroyo, J, Guirakhoo, F, Fenner, S, Zhang, Z X, Monath, T P, Chambers, T J

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A Single Amino Acid Substitution in the Envelope Protein of Chimeric Yellow Fever-Dengue 1 Vaccine Virus Reduces Neurovirulence for Suckling Mice and Viremia/Viscerotropism for Monkeys by GUIRAKHOO, F, ZHANG, Z, LANG, J, FOURNIER, C, BARRERE, B, DELAGRAVE, S, MONATH, T. P, MYERS, G, JOHNSON, B. W, PUGACHEV, K, NICHOLS, R, BROWN, N, LEVENBOOK, I, DRAPER, K, CYREK, S

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Immunogenicity, Genetic Stability, and Protective Efficacy of a Recombinant, Chimeric Yellow Fever-Japanese Encephalitis Virus (ChimeriVax-JE) as a Live, Attenuated Vaccine Candidate against Japanese Encephalitis by Guirakhoo, F., Zhang, Z.-X., Chambers, T.J., Delagrave, S., Arroyo, J., Barrett, A.D.T., Monath, T.P.

“…Yellow fever (YF) 17D vaccine virus, having a 60-year history of safe and effective use, is an ideal vector to deliver heterologous genes from other medically…”
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Recombinant, chimaeric live, attenuated vaccine (ChimeriVax™) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates by Monath, T.P, Soike, K, Levenbook, I, Zhang, Z.-X, Arroyo, J, Delagrave, S, Myers, G, Barrett, A.D.T, Shope, R.E, Ratterree, M, Chambers, T.J, Guirakhoo, F

“…Yellow fever 17D virus, a safe and effective live, attenuated vaccine, was used as a vector for genes encoding the protective antigenic determinants of a…”
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Phenotypic and Molecular Analyses of Yellow Fever 17DD Vaccine Viruses Associated with Serious Adverse Events in Brazil by Galler, R., Pugachev, K.V., Santos, C.L.S., Ocran, S.W., Jabor, A.V., Rodrigues, S.G., Marchevsky, R.S., Freire, M.S., Almeida, L.F.C., Cruz, A.C.R., Yamamura, A.M.Y., Rocco, I.M., Travassos da Rosa, E.S., Souza, L.T.M., Vasconcelos, P.F.C., Guirakhoo, F., Monath, T.P.

“…The yellow fever (YF) 17D virus is one of the most successful vaccines developed to date. Its use has been estimated to be over 400 million doses with an…”
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Antigenic structure of the flavivirus envelope protein E at the molecular level, using tick-borne encephalitis virus as a model by MANDL, C. W, FARSHAD GUIRAKHOO, HOLZMANN, H, HEINZ, F. X, KUNZ, C

“…A model of the tick-borne encephalitis virus envelope protein E is presented that contains information on the structural organization of this flavivirus…”
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Growth characteristics of the chimeric Japanese encephalitis virus vaccine candidate, ChimeriVax-JE (YF/JE SA14--14--2), in Culex tritaeniorhynchus, Aedes albopictus, and Aedes aegypti mosquitoes by Bhatt, T R, Crabtree, M B, Guirakhoo, F, Monath, T P, Miller, B R

“…The Japanese encephalitis (JE) virus vaccine candidate, ChimeriVax-JE, which consists of a yellow fever (YF) 17D virus backbone containing the prM and E genes…”
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Fusion activity of flaviviruses: comparison of mature and immature (prM-containing) tick-borne encephalitis virions by Guirakhoo, F, Heinz, F.X, Mandl, C.W, Holzmann, H, Kunz, C

“…The fusion activity of flaviviruses [tick-borne encephalitis (TBE) virus and Japanese encephalitis virus] was assessed by inducing fusion from without of C6/36…”
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Selection and partial characterization of dengue 2 virus mutants that induce fusion at elevated pH by Guirakhoo, F, Hunt, A R, Lewis, J G, Roehrig, J T

“…Two types of dengue (DEN) 2 virus mutants were selected either by repeated exposure to acidic pH (acid mutant, AM), or by the addition of ammonium chloride to…”
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A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model by Holzmann, H, Heinz, F X, Mandl, C W, Guirakhoo, F, Kunz, C

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The interactions of the flavivirus envelope proteins: implications for virus entry and release by Heinz, F X, Auer, G, Stiasny, K, Holzmann, H, Mandl, C, Guirakhoo, F, Kunz, C

“…Viral membrane proteins play an important role in the assembly and disassembly of enveloped viruses. Oligomerization and proteolytic cleavage events are…”
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Adaptation of bluetongue virus in mosquito cells results in overexpression of NS3 proteins and release of virus particles by Guirakhoo, F, Catalan, J.A, Monath, T.P

“…Adaptation of bluetongue virus (BTV) to grow in mosquito cells (C6/36) resulted in overexpression of two non-structural proteins (NS3 and NS3a) in infected…”
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A Live, Attenuated Recombinant West Nile Virus Vaccine by Monath, Thomas P., Liu, Jian, Kanesa-Thasan, Niranjan, Myers, Gwendolyn A., Nichols, Richard, Deary, Alison, McCarthy, Karen, Johnson, Casey, Ermak, Thomas, Shin, Sunheang, Arroyo, Juan, Guirakhoo, Farshad, Kennedy, Jeffrey S., Ennis, Francis A., Green, Sharone, Bedford, Philip

“…West Nile (WN) virus is an important cause of febrile exanthem and encephalitis. Since it invaded the U.S. in 1999, >19,000 human cases have been reported. The…”
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Chimeric Live, Attenuated Vaccine against Japanese Encephalitis (ChimeriVax-JE): Phase 2 Clinical Trials for Safety and Immunogenicity, Effect of Vaccine Dose and Schedule, and Memory Response to Challenge with Inactivated Japanese Encephalitis Antigen by Monath, Thomas P., Guirakhoo, Farshad, Nichols, Richard, Yoksan, Sutee, Schrader, Robert, Murphy, Chris, Blum, Paul, Woodward, Stephen, McCarthy, Karen, Mathis, Danell, Johnson, Casey, Bedford, Philip

“…ChimeriVax-JE is a live, attenuated vaccine against Japanese encephalitis, using yellow fever (YF) 17D vaccine as a vector. In a double-blind phase 2 trial, 99…”
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