Search Results - "GUIMARÃES, Elisalva Teixeira"

Potent anti-inflammatory activity of betulinic acid treatment in a model of lethal endotoxemia by Oliveira Costa, José Fernando, Barbosa-Filho, José Maria, de Azevedo Maia, Gabriela Lemos, Guimarães, Elisalva Teixeira, Meira, Cássio Santana, Ribeiro-dos-Santos, Ricardo, Pontes de Carvalho, Lain Carlos, Soares, Milena Botelho Pereira

“…Betulinic acid (BA) is a lupane-type triterpene with a number of biological activities already reported. While potent anti-HIV and antitumoral activities were…”
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Structural Design, Synthesis and Antioxidant, Antileishmania, Anti-Inflammatory and Anticancer Activities of a Novel Quercetin Acetylated Derivative by da Silva, Saul Vislei Simões, Barboza, Orlando Maia, Souza, Jéssica Teles, Soares, Érica Novaes, dos Santos, Cleonice Creusa, Pacheco, Luciano Vasconcellos, Santos, Ivanilson Pimenta, Magalhães, Tatiana Barbosa dos Santos, Soares, Milena Botelho Pereira, Guimarães, Elisalva Teixeira, Meira, Cássio Santana, Costa, Silvia Lima, da Silva, Victor Diógenes Amaral, de Santana, Lourenço Luís Botelho, de Freitas Santos Júnior, Aníbal

“…Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability…”
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Structural Investigation of Anti-Trypanosoma cruzi 2‑Iminothiazolidin-4-ones Allows the Identification of Agents with Efficacy in Infected Mice by Moreira, Diogo Rodrigo Magalhaes, Costa, Salvana Priscylla Manso, Hernandes, Marcelo Zaldini, Rabello, Marcelo Montenegro, de Oliveira Filho, Gevanio Bezerra, de Melo, Cristiane Moutinho Lagos, da Rocha, Lucas Ferreira, de Simone, Carlos Alberto, Ferreira, Rafaela Salgado, Fradico, Jordana Rodrigues Barbosa, Meira, Cássio Santana, Guimarães, Elisalva Teixeira, Srivastava, Rajendra Mohan, Pereira, Valéria Rêgo Alves, Soares, Milena Botelho Pereira, Leite, Ana Cristina Lima

“…We modified the thiazolidinic ring at positions N3, C4, and C5, yielding compounds 6–24. Compounds with a phenyl at position N3, 15–19, 22–24, exhibited better…”
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Design, synthesis and structure–activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities by Cardoso, Marcos Veríssimo de Oliveira, Moreira, Diogo Rodrigo Magalhães, Filho, Gevanio Bezerra Oliveira, Cavalcanti, Suellen Melo Tiburcio, Coelho, Lucas Cunha Duarte, Espíndola, José Wanderlan Pontes, Gonzalez, Laura Rubio, Rabello, Marcelo Montenegro, Hernandes, Marcelo Zaldini, Ferreira, Paulo Michel Pinheiro, Pessoa, Cláudia, Alberto de Simone, Carlos, Guimarães, Elisalva Teixeira, Soares, Milena Botelho Pereira, Leite, Ana Cristina Lima

“…The present work reports the synthesis and evaluation of the antitumour and immunomodulatory properties of new phthalimides derivatives designed to explore…”
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In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N -Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis by Silva, Dahara Keyse Carvalho, Teixeira, Jessicada Silva, Moreira, Diogo Rodrigo Magalhães, da Silva, Tiago Fernandes, Barreiro, Eliezer Jesus de Lacerda, de Freitas, Humberto Fonseca, Pita, Samuel Silva da Rocha, Teles, André Lacerda Braga, Guimarães, Elisalva Teixeira, Soares, Milena Botelho Pereira

“…Leishmaniasis are group of neglected diseases with worldwide distribution that affect about 12 million people. The current treatment is limited and may cause…”
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Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice by dos Santos Filho, José Maurício, Moreira, Diogo Rodrigo M., de Simone, Carlos Alberto, Ferreira, Rafaela Salgado, McKerrow, James H., Meira, Cássio Santana, Guimarães, Elisalva Teixeira, Soares, Milena Botelho Pereira

“…Oxadiazole 6d substantially reduces blood parasitemia in Trypanosoma cruzi-infected mice. We recently showed that oxadiazoles have anti-Trypanosoma cruzi…”
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Transplantation of stem cells obtained from murine dental pulp improves pancreatic damage, renal function, and painful diabetic neuropathy in diabetic type 1 mouse model by Guimarães, Elisalva Teixeira, Cruz, Gabriela da Silva, Almeida, Tiago Farias de, Souza, Bruno Solano de Freitas, Kaneto, Carla Martins, Vasconcelos, Juliana Fraga, Santos, Washington Luis Conrado dos, Santos, Ricardo Ribeiro-dos, Villarreal, Cristiane Flora, Soares, Milena Botelho Pereira

“…Diabetes mellitus (DM) is one of the most common and serious chronic diseases in the world. Here, we investigated the effects of mouse dental pulp stem cell…”
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Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs by Soares, Milena Botelho, Ribeiro-dos-Santos, Ricardo, Pinheiro, Taiana Maria Bahia, Pinheiro, Cláudia Maria Bahia, Gravely, Faye Alice, Mendonça, Marcus Vinícius Pinheiro, Guimarães, Elisalva Teixeira, Meira, Cássio Santana, Penha, Euler Moraes, Barrouin-Melo, Stella Maria

“…The use of stem cells in injury repair has been extensively investigated. Here, we examined the therapeutic effects of autologous bone marrow mesenchymal stem…”
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A Betulinic Acid Derivative, BA5, Induces G0/G1 Cell Arrest, Apoptosis Like-Death, and Morphological Alterations in Leishmania sp by Magalhães, Tatiana Barbosa Dos Santos, Silva, Dahara Keyse Carvalho, Teixeira, Jessica da Silva, De Lima, Juliana Dizaira Teles, Barbosa-Filho, José Maria, Moreira, Diogo Rodrigo Magalhães, Guimarães, Elisalva Teixeira, Soares, Milena Botelho Pereira

“…Leishmaniasis are endemic diseases caused by different species of intracellular parasites of the genus . Due to the high toxicity and drug resistance of…”
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Therapeutic Applications of Physalins: Powerful Natural Weapons by Meira, Cássio Santana, Soares, José Waldson Capinan, Dos Reis, Bruna Padilha Zurita Claro, Pacheco, Luciano Vasconcellos, Santos, Ivanilson Pimenta, Silva, Dahara Keyse Carvalho, de Lacerda, Julia Costa, Daltro, Sérgio Ricardo Teixeira, Guimarães, Elisalva Teixeira, Soares, Milena Botelho Pereira

“…Physalins, or 16,24-cyclo-13,14-seco steroids, are compounds belonging to the class of withanolides that can be found in plants of Solanaceae family, mainly in…”
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Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina by Da Silva, Vagner Cardoso, Magalhães, Bárbara Elizabeth Alves de, Magalhães, Tatiana Barbosa dos Santos, Guimarães, Elisalva Teixeira, Guedes, Alessandra da Silva, Mota, Milleno Dantas, Dos Santos, Walter Nei Lopes, Cerqueira, Bruno Antonio Veloso, Santos Júnior, Aníbal de Freitas

“…Introduction: Tradescantia zebrina is a species used mainly in South America, with few reports about its chemical composition and bioactivity. Aim: To…”
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Synthesis, crystal structure and leishmanicidal activity of new trimethoprim Ru(III), Cu(II) and Pt(II) metal complexes by Silva, Giovani Lindolfo, Dias, Júlia Scaff Moreira, Silva, Henrique Vieira Reis, Teixeira, Jessica Da Silva, De Souza, Ijaiel Rian Brito, Guimarães, Elisalva Teixeira, de Magalhães Moreira, Diogo Rodrigo, Soares, Milena Botelho Pereira, Barbosa, Marília Imaculada Frazão, Doriguetto, Antônio Carlos

“…Leishmaniasis is a parasitic disease caused by protozoa of the genus Leishmania, which has very limited treatment options and affects poor and underdeveloped…”
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In vitro and in vivo antiparasitic activity of Physalis angulata L. concentrated ethanolic extract against Trypanosoma cruzi by Meira, Cássio Santana, Guimarães, Elisalva Teixeira, dos Santos, Jamyle Andrade Ferreira, Moreira, Diogo Rodrigo Magalhães, Nogueira, Renata Campos, Tomassini, Therezinha Coelho Barbosa, Ribeiro, Ivone Maria, de Souza, Claudia Valeria Campos, Ribeiro dos Santos, Ricardo, Soares, Milena Botelho Pereira

“…The current treatment of Chagas disease, endemic in Latin America and emerging in several countries, is limited by the frequent side effects and variable…”
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Antiparasitic evaluation of betulinic acid derivatives reveals effective and selective anti-Trypanosoma cruzi inhibitors by Meira, Cássio Santana, Barbosa-Filho, José Maria, Lanfredi-Rangel, Adriana, Guimarães, Elisalva Teixeira, Moreira, Diogo Rodrigo Magalhães, Soares, Milena Botelho Pereira

“…Betulinic acid is a pentacyclic triterpenoid with several biological properties already described, including antiparasitic activity. Here, the anti-Trypanosoma…”
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Potent immunosuppressive activity of a phosphodiesterase-4 inhibitor N-acylhydrazone in models of lipopolysaccharide-induced shock and delayed-type hypersensitivity reaction by Guimarães, Elisalva Teixeira, dos Santos, Tatiana Barbosa, Silva, Dahara Keyse Carvalho, Meira, Cássio Santana, Moreira, Diogo Rodrigo Magalhães, da Silva, Tiago Fernandes, Salmon, Didier, Barreiro, Eliezer J., Soares, Milena Botelho Pereira

“…Immunosuppressive drugs are widely used for the treatment of immune-mediated diseases and inflammation, but the toxicity and side effects of the available…”
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Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae) by Meira, Cássio S., Menezes, Leociley R. A., dos Santos, Tatiana B., Macedo, Taís S., Fontes, José E. N., Costa, Emmanoel V., Pinheiro, Maria L. B., da Silva, Thanany B., Teixeira Guimarães, Elisalva, Soares, Milena B. P.

“…Natural products represent a valuable source for discovery of antiparasitic agents. Here, we describe the antiparasitic activity from essential oils extracted…”
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Activity of antimalarial drugs in vitro and in a murine model of cutaneous leishmaniasis by COSTA ROCHA, Vinícius Pinto, NONATO, Fabiana Regina, GUIMARÃES, Elisalva Teixeira, DE FREITAS, Luiz Antônio Rodrigues, PEREIRA SOARES, Milena Botelho

“…The currently used treatments for leishmaniasis, a neglected parasitic disease, are associated with several side effects, high cost and resistance of the…”
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Chemical composition and anti-Trypanosoma cruzi activity of essential oils obtained from leaves of Xylopia frutescens and X. laevigata (Annonaceae) by da Silva, Thanany Brasil, Menezes, Leociley Rocha Alencar, Sampaio, Marília Fernanda Chaves, Meira, Cássio Santana, Guimarães, Elisalva Teixeira, Soares, Milena Botelho Pereira, Prata, Ana Paula do Nascimento, Nogueira, Paulo Cesar de Lima, Costa, Emmanoel Vilaça

“…Essential oils from leaves of Xylopia frutescens (XFMJ) and two specimens of Xylopia laevigata (XLMC and XLSI) were obtained by hydrodistillation using a…”
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Betulinic acid derivative BA5, a dual NF-kB/calcineurin inhibitor, alleviates experimental shock and delayed hypersensitivity by Meira, Cássio Santana, Espírito Santo, Renan Fernandes do, dos Santos, Tatiana Barbosa, Orge, Iasmim Diniz, Silva, Dahara Keyse Carvalho, Guimarães, Elisalva Teixeira, Aragão França, Luciana Souza de, Barbosa-Filho, José Maria, Moreira, Diogo Rodrigo Magalhães, Soares, Milena Botelho Pereira

“…Betulinic acid (BA) is a naturally occurring triterpenoid with several biological properties already described, including immunomodulatory activity. Here we…”
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A new source of (R)-limonene and rotundifolone from leaves of Lippia pedunculosa (verbenaceae) and their trypanocidal properties by Santos, Nilmara Nunes, Menezes, Leociley Rocha Alencar, dos Santos, Jamyle Andrade Ferreira, Meira, Cássio Santana, Guimarhes, Elisalva Teixeira, Soares, Milena Botelho Pereira, Nepel, Angelita, Barisone, Andersson, Costa, Emmanoel Vilaça

“…Investigation by GC-FID and GC-MS of the essential oil (LPOE) from the leaves of Lippia pedunculosa revealed, as the major compounds, the monoterpenes…”
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