Histologic features of the liver in insulin resistance-associated iron overload: A study of 139 patients

The aim of the present study was to describe histologic features of the liver in insulin resistance-associated hepatic iron overload (IR-HIO), defined as the association of metabolic disorders and hepatic iron overload. We included 139 patients in the study on the basis of one or more metabolic diso...

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Bibliographic Details
Published in:	American journal of clinical pathology Vol. 116; no. 2; pp. 263 - 270
Main Authors:	TURLIN, Bruno, MENDLER, Michel H, MOIRAND, Romain, GUYADER, Dominique, GUILLYGOMARC, Anne, DEUGNIER, Yves
Format:	Journal Article
Language:	English
Published:	Chicago, IL American Society of Clinical Pathologists 01-08-2001
Subjects:	Adult Aged Associated diseases and complications Biological and medical sciences Biopsy Body Mass Index Diabetes Complications Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fatty Liver - complications Fatty Liver - pathology Female Glucose Intolerance - complications Humans Insulin Resistance Iron - analysis Iron Overload - complications Iron Overload - pathology Liver - chemistry Liver - pathology Liver Cirrhosis - complications Liver Cirrhosis - pathology Male Medical sciences Middle Aged Endocrinopathy Human Pancreatic hormone Hemochromatosis Liver Staining Hepatic disease Metabolic diseases Iron Enzymopathy Insulin Differential diagnostic Genetic disease Resistance Protein hormone Pathology Overload Digestive diseases Endocrine pancreatic diseases Comparative study
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Summary:	The aim of the present study was to describe histologic features of the liver in insulin resistance-associated hepatic iron overload (IR-HIO), defined as the association of metabolic disorders and hepatic iron overload. We included 139 patients in the study on the basis of one or more metabolic disorders and liver iron overload unrelated to usual causes. Liver biopsy specimens were reviewed, and histologic data were compared with those of a previously published, well-defined population with genetic hemochromatosis. Iron overload was characterized by a mixed pattern with iron deposits in hepatocytes and sinusoidal cells. Steatosis was present in 59.7% of patients with inflammation in 32.4% of cases. Periportal fibrosis was found in 67.4% of patients. These patients were older, had higher sinusoidal iron scores, and had a higher prevalence of steatosis and inflammation than patients without fibrosis. Iron overload in IR-HIO was histologically different from that in genetic hemochromatosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9173 1943-7722
DOI:	10.1309/WWNE-KW2C-4KTW-PTJ5