Search Results - "GUILLOUZO, André"

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs by Sharanek, Ahmad, Burban, Audrey, Burbank, Matthew, Le Guevel, Rémy, Li, Ruoya, Guillouzo, André, Guguen-Guillouzo, Christiane

“…Intrahepatic cholestasis represents a frequent manifestation of drug-induced liver injury; however, the mechanisms underlying such injuries are poorly…”
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The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics by Guillouzo, André, Corlu, Anne, Aninat, Caroline, Glaise, Denise, Morel, Fabrice, Guguen-Guillouzo, Christiane

“…Although they have several important limitations primary human hepatocytes still represent the in vitro gold standard model for xenobiotic metabolism and…”
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Optimization of the HepaRG cell model for drug metabolism and toxicity studies by Anthérieu, Sébastien, Chesné, Christophe, Li, Ruoya, Guguen-Guillouzo, Christiane, Guillouzo, André

“…► This review summarizes recent data on the performances of the human HepaRG cell line. ► The HepaRG cell line is the first human cell line able to…”
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Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes by Bachour-El Azzi, Pamela, Sharanek, Ahmad, Burban, Audrey, Li, Ruoya, Guével, Rémy Le, Abdel-Razzak, Ziad, Stieger, Bruno, Guguen-Guillouzo, Christiane, Guillouzo, André

“…The role of hepatobiliary transporters in drug-induced liver injury remains poorly understood. Various in vivo and in vitro biological approaches are currently…”
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Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells by Akhdar, Hanane, Loyer, Pascal, Rauch, Claudine, Corlu, Anne, Guillouzo, André, Morel, Fabrice

“…Abstract Acquisition of drug resistance by cancer cells is attributed to various factors including alterations in apoptotic pathways, enhanced expression of…”
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Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways by Burban, Audrey, Sharanek, Ahmad, Hüe, Romain, Gay, Marion, Routier, Sylvain, Guillouzo, André, Guguen-Guillouzo, Christiane

“…The penicillinase-resistant antibiotics (PRAs), especially the highly prescribed flucloxacillin, caused frequent liver injury via mechanisms that remain…”
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Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in human hepatocytes by Rogue, Alexandra, Lambert, Carine, Jossé, Rozenn, Antherieu, Sebastien, Spire, Catherine, Claude, Nancy, Guillouzo, André

“…Several glitazones (PPARγ agonists) and glitazars (dual PPARα/γ agonists) have been developed to treat hyperglycemia and, simultaneously, hyperglycemia and…”
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In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments by Pomponio, Giuliana, Savary, Camille C., Parmentier, Céline, Bois, Frederic, Guillouzo, André, Romanelli, Luca, Richert, Lysiane, Di Consiglio, Emma, Testai, Emanuela

“…•Amiodarone biokinetics was studied and modelled in two human liver cells after acute and repeated treatment.•Amiodarone bioavailability was influenced by…”
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Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project by Mueller, Stefan O., Guillouzo, André, Hewitt, Philip G., Richert, Lysiane

“…•Overview on the work performed within the EU-funded Predict-IV project.•Selected drug compounds analyzed in rat and human primary hepatocytes and HepaRG…”
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Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells by Savary, Camille C, Jossé, Rozenn, Bruyère, Arnaud, Guillet, Fabrice, Robin, Marie-Anne, Guillouzo, André

“…Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other…”
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Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver by Rogue, Alexandra, Spire, Catherine, Brun, Manuel, Claude, Nancy, Guillouzo, André

“…Thiazolidinediones are a class of Peroxisome Proliferator Activated Receptor γ (PPARγ) agonists that reduce insulin resistance in type 2 diabetic patients…”
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Functional expression, inhibition and induction of CYP enzymes in HepaRG cells by Turpeinen, Miia, Tolonen, Ari, Chesne, Christophe, Guillouzo, André, Uusitalo, Jouko, Pelkonen, Olavi

“…Practically all human hepatocyte cell lines are deficient in major cytochrome P450 (CYP)-related enzyme activities, making them unrepresentative of in vivo…”
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GATA-1 is essential in EGF-mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells by ANDRIEUX, Lise O, FAUTREL, Alain, BESSARD, Anne, GUILLOUZO, André, BAFFET, Georges, LANGOUËT, Sophie

“…The nucleotide excision repair (NER) pathway and its leading gene excision-repair cross-complementary 1 (ERCC1) have been shown to be up-regulated in…”
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Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period by Savary, Camille C., Jiang, Xiaoqi, Aubry, Marc, Jossé, Rozenn, Kopp-Schneider, Annette, Hewitt, Philip, Guillouzo, André

“…•The transcriptome of HepaRG cells was analyzed at confluence over a 2-week period.•Less than 1% of expressed genes was found to be deregulated over this…”
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From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells by Burbank, Matthew Gibson, Sharanek, Ahmad, Burban, Audrey, Mialanne, Hervé, Aerts, Hélène, Guguen-Guillouzo, Christiane, Weaver, Richard John, Guillouzo, André

“…Several endothelin receptor antagonists (ERAs) have been developed for the treatment of pulmonary arterial hypertension (PAH). Some of them have been related…”
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Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes by Petit, Elise, Langouet, Sophie, Akhdar, Hanane, Nicolas-Nicolaz, Christophe, Guillouzo, André, Morel, Fabrice

“…Thiopurines (azathioprine, 6-mercaptopurine and 6-thioguanine) are therapeutic compounds widely administered in the clinic for their multiple uses (autoimmune…”
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Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines by Dumont, Julie, Jossé, Rozenn, Lambert, Carine, Anthérieu, Sébastien, Laurent, Véronique, Loyer, Pascal, Robin, Marie-Anne, Guillouzo, André

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) are two of the most common heterocyclic…”
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General review on in vitro hepatocyte models and their applications by Guguen-Guillouzo, Christiane, Guillouzo, Andre

“…In vitro hepatocyte models represent very useful systems in both fundamental research and various application areas. Primary hepatocytes appear as the closest…”
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Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes by Piton, Amélie, Rauch, Claudine, Langouet, Sophie, Guillouzo, André, Morel, Fabrice

“…Oltipraz, a synthetic derivative of the cruciferous vegetable product 1,2-dithiole-3-thione, is considered as a potent chemoprotectant. Previously, we have…”
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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models by Weaver, Richard J., Blomme, Eric A., Chadwick, Amy E., Copple, Ian M., Gerets, Helga H. J., Goldring, Christopher E., Guillouzo, Andre, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig, Juhila, Satu, Klingmüller, Ursula, Labbe, Gilles, Liguori, Michael J., Lovatt, Cerys A., Morgan, Paul, Naisbitt, Dean J., Pieters, Raymond H. H., Snoeys, Jan, van de Water, Bob, Williams, Dominic P., Park, B. Kevin

“…Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in…”
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