Search Results - "GUILLEMIN, G"

Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways by Hallal, S., Mallawaaratchy, D. M., Wei, H., Ebrahimkhani, S., Stringer, B. W., Day, B. W., Boyd, A. W., Guillemin, G. J., Buckland, M. E., Kaufman, Kimberley L.

“…The role of astrocytes is becoming increasingly important to understanding how glioblastoma (GBM) tumor cells diffusely invade the brain. Yet, little is known…”
Get full text

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation by Brundin, L, Sellgren, C M, Lim, C K, Grit, J, Pålsson, E, Landén, M, Samuelsson, M, Lundgren, K, Brundin, P, Fuchs, D, Postolache, T T, Traskman-Bendz, L, Guillemin, G J, Erhardt, S

“…Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is involved in neuroinflammation and…”
Get full text

Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases? A Response to a Critical Review of the BMAA Hypothesis by RA, Dunlop, SA, Banack, SL, Bishop, JS, Metcalf, SJ, Murch, DA, Davis, EW, Stommel, O, Karlsson, EB, Brittebo, AD, Chatziefthimiou, VX, Tan, GG, Guillemin, PA, Cox, DC, Mash, WG, Bradley

“…In a literature survey, Chernoff et al. ( 2017 ) dismissed the hypothesis that chronic exposure to β- N -methylamino-L-alanine (BMAA) may be a risk factor for…”
Get full text

Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus by Guillemin, G. J., Brew, B. J., Noonan, C. E., Takikawa, O., Cullen, K. M.

“…The present immunohistochemical study provides evidence that the kynurenine pathway is up‐regulated in Alzheimer's disease (AD) brain, leading to increases in…”
Get full text

Neuroprotective Effects of Rosmarinic Acid on Ciguatoxin in Primary Human Neurons by Braidy, N., Matin, A., Rossi, F., Chinain, M., Laurent, D., Guillemin, G. J.

“…Ciguatoxin (CTX), is a toxic compound produced by microalgae (dinoflagellate) Gambierdiscus spp., and is bio-accumulated and bio-transformed through the marine…”
Get full text

Excitotoxicity in the Pathogenesis of Autism by Essa, M. M., Braidy, N., Vijayan, K. R., Subash, S., Guillemin, G. J.

“…Autism is a debilitating neurodevelopment disorder characterised by stereotyped interests and behaviours, and abnormalities in verbal and non-verbal…”
Get full text

The p38-MK2-HuR pathway potentiates EGFRvIII–IL-1β-driven IL-6 secretion in glioblastoma cells by Gurgis, F M S, Yeung, Y T, Tang, M X M, Heng, B, Buckland, M, Ammit, A J, Haapasalo, J, Haapasalo, H, Guillemin, G J, Grewal, T, Munoz, L

“…The microenvironment of glioblastoma (GBM) contains high levels of inflammatory cytokine interleukin 6 (IL-6), which contributes to promote tumour progression…”
Get full text

l-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI) by Dunlop, R. A., Powell, J. T., Metcalf, J. S., Guillemin, G. J., Cox, P. A.

“…The unfolded protein response (UPR) is a highly evolutionarily conserved response to endoplasmic reticulum (ER) stress, which functions to return cells to…”
Get full text

Kynurenines, Gender and Neuroinflammation; Showcase Schizophrenia by de Bie, J., Lim, C. K., Guillemin, G. J.

“…Schizophrenia has a clear sexual dimorphism in age of onset and progression. The underlying mechanisms of this dimorphism are not known, but may be found in…”
Get full text

Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways by Hallal, S., Mallawaaratchy, D. M., Wei, H., Ebrahimkhani, S., Stringer, B. W., Day, B. W., Boyd, A. W., Guillemin, G. J., Buckland, M. E., Kaufman, Kimberley L.

Get full text

Tissue-engineered bone regeneration by Petite, Herve, Viateau, Veronique, Bensaïd, Wassila, Meunier, Alain, de Pollak, Cindy, Bourguignon, Marianne, Oudina, Karim, Sedel, Laurent, Guillemin, Genevieve

“…Bone lesions above a critical size become scarred rather than regenerated, leading to nonunion. We have attempted to obtain a greater degree of regeneration by…”
Get full text

Mechanisms of l-Serine Neuroprotection in vitro Include ER Proteostasis Regulation by Dunlop, R. A., Powell, J., Guillemin, G. J., Cox, P. A.

“…β-N-methylamino- l -alanine (L-BMAA) is a neurotoxic non-protein amino acid produced by cyanobacteria. Recently, chronic dietary exposure to l -BMAA was shown…”
Get full text

Progesterone Alters Kynurenine Pathway Activation in IFN-γ-Activated Macrophages - Relevance for Neuroinflammatory Diseases by de Bie, J., Lim, C. K., Guillemin, G. J.

“…We have previously demonstrated that the kynurenine pathway (KP), the major biochemical pathway for tryptophan metabolism, is dysregulated in many inflammatory…”
Get full text

Beneficial Effects of Desferrioxamine on Encapsulated Human Islets—In Vitro and In Vivo Study by Vaithilingam, V., Oberholzer, J., Guillemin, G. J., Tuch, B. E.

“…As many as 2000 IEQs (islet equivalent) of encapsulated human islets are required to normalize glucose levels in diabetic mice. To reduce this number,…”
Get full text

Nanomaterials and their role in advancing biodiesel feedstock production: A comprehensive review by Hosseinzadeh-Bandbafha, Homa, Hamed Kazemi Shariat Panahi, Dehhaghi, Mona, Orooji, Yasin, Shahbeik, Hossein, Mahian, Omid, Karimi-Maleh, Hassan, Sulaiman, Alawi, Changtong Mei, Kiehbadroudinezhad, Mohammadali, Abdul-Sattar Nizami, Guillemin, Gilles G, Lam, Su Shiung, Peng, Wanxi, Chen, Xiangmeng, Ki-Hyun, Kim, Aghbashlo, Mortaza, Tabatabaei, Meisam

“…Sustainable socio-economic development largely depends on the sustainability of the energy supply from economic, environmental, and public health perspectives…”
Get full text

Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds by Jacobs, K R, Guillemin, G J, Lovejoy, D B

“…Kynurenine 3-monooxygenase (KMO) is a well-validated therapeutic target for the treatment of neurodegenerative diseases, including Alzheimer's disease (AD) and…”
Get more information

Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2 by Gurgis, FMS, Åkerfeldt, MC, Heng, B, Wong, C, Adams, S, Guillemin, GJ, Johns, TG, Chircop, M, Munoz, L

“…MAPK-activated protein kinase 2 (MK2) is a checkpoint kinase involved in the DNA damage response. MK2 inhibition enhances the efficacy of chemotherapeutic…”
Get full text

Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle by Zepf, Florian Daniel, Stewart, R M, Guillemin, G, Ruas, J L

Get more information

Serotonin decreases HIV‐1 replication in primary cultures of human macrophages through 5‐HT1A receptors by Manéglier, B, Guillemin, G J, Clayette, P, Rogez‐Kreuz, C, Brew, B J, Dormont, D, Advenier, C, Therond, P, Spreux‐Varoquaux, O

“…Background and purpose: 5‐HT (serotonin) is known to be involved in neuroinflammation and immunoregulation. The human immunodeficiency virus (HIV) targets…”
Get full text

Great expectations: Nutritional medicine as a mainstream in clinical psychiatry and weighing opportunities against risks by Zepf, F.D, Stewart, R.M, Hood, S, Guillemin, G.J, On behalf of the International Society for Tryptophan Research (ISTRY)

Get full text