Search Results - "GUILD, B. C"

Helicobacter pylori Physiology Predicted from Genomic Comparison of Two Strains by DOIG, P, DE JONGE, B. L, MOIR, D. T, VOVIS, G. F, TRUST, T. J, ALM, R. A, BROWN, E. D, URIA-NICKELSEN, M, NOONAN, B, MILLS, S. D, TUMMINO, P, CARMEL, G, GUILD, B. C

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Humanization of Murine Monoclonal Antibodies Through Variable Domain Resurfacing by Roguska, Michael A., Pedersen, Jan T., Keddy, Christine A., Henry, Andrew H., Searle, Stephen J., Lambert, John M., Goldmacher, Victor S., Blattler, Walter A., Rees, Anthony R., Guild, Braydon C.

“…Two murine monoclonal antibodies, N901 (anti-CD56) and anti-B4 (anti-CD19), were humanized by a process we call "resurfacing." A systematic analysis of known…”
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Induction of apoptosis by the Bcl-2 homologue Bak by Chittenden, Thomas, Harrington, Elizabeth A, O'Connor, Rosemary, Remington, Cathy, Lutz, Robert J, Evan, Gerard I, Guild, Braydon C

“…Cells are eliminated in a variety of physiological settings by apoptosis, a genetically encoded process of cellular suicide. Apoptosis comprises an intrinsic…”
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Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori by Alm, Richard A, Ling, Lo-See L, Moir, Donald T, King, Benjamin L, Brown, Eric D, Doig, Peter C, Smith, Douglas R, Noonan, Brian, Guild, Braydon C, deJonge, Boudewijn L, Carmel, Gilles, Tummino, Peter J, Caruso, Anthony, Uria-Nickelsen, Maria, Mills, Debra M, Ives, Cameron, Gibson, Rene, Merberg, David, Mills, Scott D, Jiang, Qin, Taylor, Diane E, Vovis, Gerald F, Trust, Trevor J

“…Helicobacter pylori, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life…”
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Phage Display of Ricin B Chain and its Single Binding Domains: System for Screening Galactose-Binding Mutants by Swimmer, Candace, Lehar, Sophie M., McCafferty, John, Chiswell, David J., Blattler, Walter A., Guild, Braydon C.

“…We demonstrate that the B chain of ricin toxin preserves its lectin activity when expressed as a fusion protein on the surface of fd phage. Moreover, B chain,…”
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Retroviral Transfer of a Murine cDNA for Multidrug Resistance Confers Pleiotropic Drug Resistance to Cells without Prior Drug Selection by Guild, Braydon C., Mulligan, Richard C., Gros, Philippe, Housman, David E.

“…We have constructed a retrovirus expression vector that carries the murine mdr cDNA transcribed under the control of the human H4 histone promoter to examine…”
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Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivo by GUILD, B. C, FINER, M. H, HOUSMAN, D. E, MULLIGAN, R. C

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Comparison of surface accessible residues in human and murine immunoglobulin Fv domains. Implication for humanization of murine antibodies by Pedersen, J T, Henry, A H, Searle, S J, Guild, B C, Roguska, M, Rees, A R

“…Statistical analysis of a database of unique human and murine immunoglobulin heavy chain and light chain variable regions reveals that the precise patterns of…”
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Anti-B4-Blocked Ricin Synergizes With Doxorubicin and Etoposide on Multidrug-Resistant and Drug-Sensitive Tumors by O’Connor, Rosemary, Liu, Changnian, Ferris, Cynthia A., Guild, Braydon C., Teicher, Beverly A., Corvi, Christopher, Liu, Yimao, Arceci, Robert J., Goldmacher, Victor S., Lambert, John M., Blättler, Walter A.

“…Anti-B4–blocked ricin (anti-B4–bR) is an immunotoxin directed against CD19-positive cells that is currently being tested in several B-cell leukemia/lymphoma…”
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Human and murine class I MHC antigens share conserved serine 335, the site of HLA phosphorylation in vivo by Guild, B C, Strominger, J L

“…The site of phosphorylation of the HLA-B7 antigen in vivo is serine 335, which is located in the intracellular region. Pseudomonas fragi protease was used in…”
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Genetics of multidrug resistance: relationship of a cloned gene to the complete multidrug resistant phenotype by CROOP, J. M, GUILD, B. C, GROS, P, HOUSMAN, D. E

“…Resistance to multiple chemotherapeutic agents remains the major cause of failure in cancer chemotherapy. Multidrug resistant cell lines developed in vitro…”
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HLA-A2 and HLA-B7 Antigens are Phosphorylated in vitro by Rous Sarcoma Virus Kinase (pp60v-src) at a Tyrosine Residue Encoded in a Highly Conserved Exon of the Intracellular Domain by Guild, Braydon C., Erikson, Raymond L., Strominger, Jack L.

“…HLA-A2 and -B7 antigens are phosphorylated by Rous sarcoma kinase (pp60v-src) in vitro. The phosphate group is attached to the heavy chains as determined by…”
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HLA-A2 antigen phosphorylation in vitro by cyclic AMP-dependent protein kinase. Sites of phosphorylation and segmentation in class i major histocompatibility complex gene structure by Guild, B C, Strominger, J L

“…The heavy chain of the HLA-A2 antigen is phosphorylated by cyclic AMP-dependent protein kinase at two serine residues of the intracellular region. Limited…”
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Reconstitution of Purified Detergent-Soluble HLA-A and HLA-B Antigens into Phospholipid Vesicles by Engelhard, Victor H., Guild, Braydon C., Helenius, Ari, Terhorst, Cox, Strominger, Jack L.

“…Purified detergent-soluble human histocompatibility antigens (HLA-A and HLA-B) were reconstituted into phospholipid vesicles by mixing the protein and lipid…”
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Phosphorylation in vivo and in vitro of Human Histocompatibility Antigens (HLA-A and HLA-B) in the Carboxy-Terminal Intracellular Domain by Pober, Jordan S., Guild, Braydon C., Strominger, Jack L.

“…HLA-A and -B antigens are phosphorylated in transformed lymphoblastoid cells and peripheral blood lymphocytes, both incubated with 32Pi. The phosphate group is…”
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Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells by Lehar, S M, Nacht, M, Jacks, T, Vater, C A, Chittenden, T, Guild, B C

“…To search for candidate genes involved in p53-mediated apoptosis, the differential display technique was used to identify RNA species whose expression was…”
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A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing by Roguska, Michael A., Pedersen, Jan. T., Henry, Andrew H., Searle, Stephen M.J., Roja, C.Michelle, Avery, Brian, Hoffee, Mary, Cook, Sherri, Lambert, John M., Blättler, Walter A., Rees, Anthony R., Guild, Braydon C.

“…The variable domain resurfacing and CDR-grafting approaches to antibody humanization were compared directly on the two murine monoclonal antibodies N901…”
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The molecular biology of Gaucher disease and the potential for gene therapy by Choudary, P V, Tsuji, S, Martin, B M, Guild, B C, Mulligan, R C, Murray, G J, Barranger, J A, Ginns, E I

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Mutational and structural analysis of the lectin activity in binding domain 2 of ricin B chain by Lehar, S M, Pedersen, J T, Kamath, R S, Swimmer, C, Goldmacher, V S, Lambert, J M, Blättler, W A, Guild, B C

“…The study of the lectin binding sites of ricin B chain and of other homologous members of the small gene family that make up ricin-like molecules has revealed…”
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Expression and secretion of a recombinant ricin immunotoxin from murine myeloma cells by Krek, C E, Ladino, C A, Goldmacher, V S, Blättler, W A, Guild, B C

“…Expression plasmids carrying a humanized N901 immunoglobulin heavy chain gene (hN901HC) fused to a gene encoding the native B chain of ricin toxin (RTB),…”
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