Search Results - "GUILBAUD, Nicolas"

Melanoma chemotherapy leads to the selection of ABCB5-expressing cells by Chartrain, Marine, Riond, Joëlle, Stennevin, Aline, Vandenberghe, Isabelle, Gomes, Bruno, Lamant, Laurence, Meyer, Nicolas, Gairin, Jean Edouard, Guilbaud, Nicolas, Annereau, Jean Philippe

“…Metastatic melanoma is the most aggressive skin cancer. Recently, phenotypically distinct subpopulations of tumor cells were identified. Among them,…”
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Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA by Stéphane Vispé, Luc DeVries, Laurent Créancier, Jérome Besse, Sophie Bréand, David J. Hobson, Jesper Q. Svejstrup, Jean-Philippe Annereau, Didier Cussac, Charles Dumontet, Nicolas Guilbaud, Jean-Marc Barret, Christian Bailly

“…Triptolide, a natural product extracted from the Chinese plant Tripterygium wilfordii , possesses antitumor properties. Despite numerous reports showing the…”
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KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties by NAKAMURA, Kazuhide, TAGUCHI, Eri, SUZUKI, Rika, KUBO, Kinya, SHIBUYA, Masabumi, ISOE, Toshiyuki, MIURA, Toru, YAMAMOTO, Atsushi, TAKAHASHI, Kazumi, BICHAT, Francis, GUILBAUD, Nicolas, HASEGAWA, Kazumasa, KUBO, Kazuo, FUJIWARA, Yasunari

“…Vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis by stimulating the proangiogenic signaling of endothelial cells via activation…”
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Actinic keratosis modelling in mice: A translational study by Pillon, Arnaud, Gomes, Bruno, Vandenberghe, Isabelle, Cartron, Valérie, Cèbe, Patrick, Blanchet, Jean-Christophe, Sibaud, Vincent, Guilbaud, Nicolas, Audoly, Laurent, Lamant, Laurence, Kruczynski, Anna

“…Actinic keratoses (AK) are pre-malignant cutaneous lesions caused by prolonged exposure to ultraviolet radiation. As AKs lesions are generally accepted to be…”
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Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs by Liéby-Muller, Frédéric, Marion, Frédéric, Schmitt, Philippe, Annereau, Jean-Philippe, Kruczynski, Anna, Guilbaud, Nicolas, Bailly, Christian

“…(-)-Cryptopleurine 1 is one of the most potent anti-proliferative member of the phenanthroquinolizidine class of alkaloids. We report here the synthesis of…”
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An integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase II by Chelouah, Sonia, Monod-Wissler, Caroline, Bailly, Christian, Barret, Jean-Marc, Guilbaud, Nicolas, Vispé, Stéphane, Käs, Emmanuel

“…F14512 is a novel anti-tumor molecule based on an epipodophyllotoxin core coupled to a cancer-cell vectoring spermine moiety. This polyamine linkage is assumed…”
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Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor by McKillop, David, Partridge, Elizabeth A, Kemp, John V, Spence, Mike P, Kendrew, Jane, Barnett, Sharon, Wood, Phillippa G, Giles, Petrina B, Patterson, Andrew B, Bichat, Francis, Guilbaud, Nicolas, Stephens, Trevor C

“…The relative distribution of gefitinib-related material in nude mice bearing s.c. human tumor xenografts and in an orthotopic rat lung tumor model was…”
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CD10 expression by melanoma cells is associated with aggressive behavior in vitro and predicts rapid metastatic progression in humans by Thomas-Pfaab, Marianne, Annereau, Jean-Philippe, Munsch, Coline, Guilbaud, Nicolas, Garrido, Ignacio, Paul, Carle, Brousset, Pierre, Lamant, Laurence, Meyer, Nicolas

“…Abstract Background No biological or molecular marker of primary melanoma tumor cells has been shown to predict clinical outcome in melanoma. Objective To…”
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Optical imaging of disseminated leukemia models in mice with near-infrared probe conjugated to a monoclonal antibody by Pesnel, Sabrina, Pillon, Arnaud, Créancier, Laurent, Lerondel, Stéphanie, Le Pape, Alain, Recher, Christian, Demur, Cécile, Guilbaud, Nicolas, Kruczynski, Anna

“…The assessment of anticancer agents to treat leukemia needs to have animal models closer to the human pathology such as implantation in immunodeficient mice of…”
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Pursaethosides A-E, triterpene saponins from Entada pursaetha by Tapondjou, A.L, Miyamoto, T, Mirjolet, J.F, Guilbaud, N, Lacaille-Dubois, M.A

“…Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the n-BuOH extract of the seed kernels of Entada pursaetha along with the known…”
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Marked Antitumor Activity of a New Potent Acronycine Derivative in Orthotopic Models of Human Solid Tumors by GUILBAUD, Nicolas, KRAUS-BERTHIER, Laurence, ATASSI, Ghanem, HICKMAN, John, PIERRE, Alain, MEYER-LOSIC, Florence, MALIVET, Virginie, CHACUN, Christine, JAN, Michel, TILLEQUIN, Francois, MICHEL, Sylvie, KOCH, Michel, PFEIFFER, Bruno

“…S 23906-1 is a novel acronycine derivative selected on the basis of its potency in vitro . We investigated the antitumor activity of S 23906-1 against several…”
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Histology and Sensitivity to Anticancer Drugs of Two Human Non-Small Cell Lung Carcinomas Implanted in the Pleural Cavity of Nude Mice by KRAUS-BERTHIER, L, JAN, M, GUILBAUD, N, NAZE, M, PIERRE, A, ATASSI, G

“…We have established two metastatic models of human non-small cell lung carcinoma (NSCLC)—the NCI-H460 large-cell carcinoma and the A549 adenocarcinoma—by…”
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Synthesis and Cytotoxic and Antitumor Activity of Esters in the 1,2-Dihydroxy-1,2-dihydroacronycine Series by Elomri, Abdelhakim, Mitaku, Sofia, Michel, Sylvie, Skaltsounis, Alexios-Léandros, Tillequin, François, Koch, Michel, Pierré, Alain, Guilbaud, Nicolas, Léonce, Stéphane, Kraus-Berthier, Laurence, Rolland, Yves, Atassi, Ghanem

“…Seven 1,2-dihydroxy-1,2-dihydroacronycine and 1,2-dihydroxy-1,2-dihydro-6-demethoxyacronycine esters and diesters were synthesized via osmic oxidation of…”
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Synthesis of N, N′-disubstituted 3-aminobenzo[ c] and [ d]azepin-2-ones as potent and specific farnesyl transferase inhibitors by Le Diguarher, Thierry, Ortuno, Jean-Claude, Shanks, David, Guilbaud, Nicolas, Pierré, Alain, Raimbaud, Eric, Fauchère, Jean-Luc, Hickman, John A, Tucker, Gordon C, Casara, Patrick J

“…A structure–activity study was performed by synthesis on N, N′-disubstitution of 3-aminobenzo[ c] and [ d]azepin-2-one 2 and 3 to afford potent and specific…”
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Comparison of the pharmacological profile of an olivacine derivative and a potential prodrug by KRAUS-BERTHIER, Laurence, GUILBAUD, Nicolas, LEONCE, Stéphane, PARKER, Tracy, GENISSEL, Patrick, GUILLONNEAU, Claude, GOLDSTEIN, Solo, ATASSI, Ghanem, PIERRE, Alain

“…The new olivacine derivative S 16020-2 (NSC-659687) has entered clinical trials on the basis of a marked antitumor activity in experimental models. Amongst the…”
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The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks by Bombarde, Oriane, Larminat, Florence, Gomez, Dennis, Frit, Philippe, Racca, Carine, Gomes, Bruno, Guilbaud, Nicolas, Calsou, Patrick

“…Poisons of topoisomerase II (TOP2) kill cancer cells by preventing religation of intermediate DNA breaks during the enzymatic process and thus by accumulating…”
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Acronycine derivatives as promising antitumor agents by Guilbaud, Nicolas, Léonce, Stéphane, Tillequin, François, Koch, Michel, Hickman, John A, Pierré, Alain

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Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer by Leary, Alexandra, Le Tourneau, Christophe, Varga, Andrea, Sablin, Marie-Paule, Gomez-Roca, Carlos, Guilbaud, Nicolas, Petain, Aurelie, Pavlyuk, Mariya, Delord, Jean-Pierre

“…Summary Purpose To determine the maximum tolerated dose (MTD) of F14512, a topoisomerase II inhibitor designed to target cancer cells through the polyamine…”
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The nonlysosomal β‐glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells by Sorli, Sonia‐Caroline, Colié, Sandra, Albinet, Virginie, Dubrac, Alexandre, Touriol, Christian, Guilbaud, Nicolas, Bedia, Carmen, Fabriàs, Gemma, Casas, Josefina, Ségui, Bruno, Levade, Thierry, Andrieu‐Abadie, Nathalie

“…Glycosphingolipids, which are abundant at the surface of melanoma cells, play crucial roles in tumor progression. We investigated whether a newly described…”
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Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II by Brel, Viviane, Annereau, Jean-Philippe, Vispé, Stéphane, Kruczynski, Anna, Bailly, Christian, Guilbaud, Nicolas

“…The polyamines transport system (PTS) is usually enhanced in cancer cells and can be exploited to deliver anticancer drugs. The spermine-conjugated…”
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