Search Results - "GUICHEUX, J."

Cartilage tissue engineering: From biomaterials and stem cells to osteoarthritis treatments by Vinatier, C, Guicheux, J

“…Abstract Articular cartilage is a non-vascularized and poorly cellularized connective tissue that is frequently damaged as a result of trauma and degenerative…”
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An injectable vehicle for nucleus pulposus cell-based therapy by Collin, Estelle C, Grad, Sibylle, Zeugolis, Dimitrios I, Vinatier, Claire S, Clouet, Johann R, Guicheux, Jérôme J, Weiss, Pierre, Alini, Mauro, Pandit, Abhay S

“…Abstract An injectable hydrogel, acting as a reservoir for cell delivery and mimicking the native environment, offers promise for nucleus pulposus (NP) repair…”
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Assessing glucose and oxygen diffusion in hydrogels for the rational design of 3D stem cell scaffolds in regenerative medicine by Figueiredo, L., Pace, R., D'Arros, C., Réthoré, G., Guicheux, J., Le Visage, C., Weiss, P.

“…Hydrogels are attractive biomaterials for replicating cellular microenvironments, but attention needs to be given to hydrogels diffusion properties. A large…”
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Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium by Khoshniat, S, Bourgine, A, Julien, M, Petit, M, Pilet, P, Rouillon, T, Masson, M, Gatius, M, Weiss, P, Guicheux, J, Beck, L

“…Abstract Inorganic phosphate (Pi) acts as a signaling molecule in bone-forming cells, affecting cell functions and gene expression. Particularly, Pi stimulates…”
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Degenerative lumbar disc disease: in vivo data support the rationale for the selection of appropriate animal models by Fusellier, M, Clouet, J, Gauthier, O, Tryfonidou, M, Le Visage, C, Guicheux, J

“…Since low-back pain is increasing in ageing populations, current research efforts are focused on obtaining a better understanding of the pathophysiology of…”
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Correlation between magnetic resonance, X-ray imaging alterations and histological changes in an ovine model of age-related disc degeneration by Bouhsina, N, Decante, C, Hardel, J B, Madec, S, Abadie, J, Hamel, A, Le Visage, C, Lesoeur, J, Guicheux, J, Clouet, J, Fusellier, M

“…Sheep are one of the many animal models used to investigate the pathophysiology of disc degeneration and the regenerative strategies for intervertebral disc…”
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injectable cellulose-based hydrogel for the transfer of autologous nasal chondrocytes in articular cartilage defects by Vinatier, C, Gauthier, O, Fatimi, A, Merceron, C, Masson, M, Moreau, A, Moreau, F, Fellah, B, Weiss, P, Guicheux, J

“…Articular cartilage has a low capacity for spontaneous repair. To promote the repair of this tissue, the transfer of autologous chondrocytes using a…”
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Controlling the biological function of calcium phosphate bone substitutes with drugs by Verron, E., Bouler, J.M., Guicheux, J.

“…There is a growing interest in bone tissue engineering for bone repair after traumatic, surgical or pathological injury, such as osteolytic tumor or…”
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Development and characterization of a humanized mouse model of osteoarthritis by Bodic, B., Boutet, M.A., Boyer, C., Metayer, B., Vignes, C., Lesoeur, J., Veziers, J., Daguin, V., Haspot, F., Maugars, Y., Djouad, F., Guicheux, J., Vinatier, C.

“…In light of the role of immune cells in OA pathogenesis, the development of sophisticated animal models closely mimicking the immune dysregulation during the…”
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Articular cartilage regeneration and bioengineering: From biomaterials to stem cells by Guicheux, J

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Activation of p38 Mitogen‐Activated Protein Kinase and c‐Jun‐NH2‐Terminal Kinase by BMP‐2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation by Guicheux, J, Lemonnier, J, Ghayor, C, Suzuki, A, Palmer, G, Caverzasio, J

“…Signaling involved in osteoblastic cell differentiation remains largely unknown. This study further investigates mechanisms involved in BMP‐2‐induced…”
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Clinical relevance of 3D gait analysis in patients with haemophilia by Fouasson‐Chailloux, A., Maugars, Y., Vinatier, C., Trossaert, M., Menu, P., Rannou, F., Guicheux, J., Dauty, M.

“…Haemophilia is characterized by a congenital deficiency of clotting factor VIII or IX. One of the consequences of haemophilia is joint bleedings. Repetitive…”
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Expression of Phosphate Transporters during Dental Mineralization by Merametdjian, L., Beck-Cormier, S., Bon, N., Couasnay, G., Sourice, S., Guicheux, J., Gaucher, C., Beck, L.

“…The importance of phosphate (Pi) as an essential component of hydroxyapatite crystals suggests a key role for membrane proteins controlling Pi uptake during…”
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Enriching a cellulose hydrogel with a biologically active marine exopolysaccharide for cell‐based cartilage engineering by Rederstorff, E., Rethore, G., Weiss, P., Sourice, S., Beck‐Cormier, S., Mathieu, E., Maillasson, M., Jacques, Y., Colliec‐Jouault, S., Fellah, B. H., Guicheux, J., Vinatier, C.

“…The development of biologically and mechanically competent hydrogels is a prerequisite in cartilage engineering. We recently demonstrated that a marine…”
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Identification of TGFβ signatures in six murine models mimicking different osteoarthritis clinical phenotypes by Maumus, M., Noël, D., Ea, H.K., Moulin, D., Ruiz, M., Hay, E., Houard, X., Cleret, D., Cohen-Solal, M., Jacques, C., Jouzeau, J.-Y., Lafage-Proust, M.-H., Reboul, P., Sellam, J., Vinatier, C., Rannou, F., Jorgensen, C., Guicheux, J., Berenbaum, F.

“…TGFβ is a key player in cartilage homeostasis and OA pathology. However, few data are available on the role of TGFβ signalling in the different OA phenotypes…”
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Molecular effects of gallium on osteoclastic differentiation of mouse and human monocytes by Verron, E., Loubat, A., Carle, G.F., Vignes-Colombeix, C., Strazic, I., Guicheux, J., Rochet, N., Bouler, J.M., Scimeca, J.C.

“…We had previously reported that gallium (Ga) inhibited both the differentiation and resorbing activity of osteoclasts in a dose-dependent manner. To provide…”
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Non-invasive and functional evaluation of osteoarthritis by radiographic and gait analyses: application to the anti-inflammatory and anti-catabolic effects of a combination of natural molecules by Le Tilly, E, Hivernaud, V, Guicheux, J, Beck, L

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Design and evaluation of electrospun structured biomaterials for Annulus fibrosus regeneration by Gluais, M.D, Clouet, J, Chew, S, Guicheux, J, Le Visage, C

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A new boronate ester-based crosslinking strategy allows the design of nonswelling and long-term stable dynamic covalent hydrogels by Lagneau, N, Terriac, L, Tournier, P, Helesbeux, J-J, Viault, G, Séraphin, D, Halgand, B, Loll, F, Garnier, C, Jonchère, C, Rivière, M, Tessier, A, Lebreton, J, Maugars, Y, Guicheux, J, Le Visage, C, Delplace, V

“…Dynamic hydrogels are viscoelastic materials that can be designed to be self-healing, malleable, and injectable, making them particularly interesting for a…”
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Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration by Peter, B., Pioletti, D.P., Laïb, S., Bujoli, B., Pilet, P., Janvier, P., Guicheux, J., Zambelli, P.-Y., Bouler, J.-M., Gauthier, O.

“…Despite total hip replacement (THR) gives generally satisfactory results, the quality of outcome in young patients is markedly decreased compared to the…”
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