Search Results - "GUICHELAAR, Teun"

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization by van Loosdregt, Jorg, Vercoulen, Yvonne, Guichelaar, Teun, Gent, Yoony Y.J., Beekman, Jeffrey M., van Beekum, Olivier, Brenkman, Arjan B., Hijnen, Dirk-Jan, Mutis, Tuna, Kalkhoven, Eric, Prakken, Berent J., Coffer, Paul J.

“…Regulatory T cells (Tregs) are a specific subset of lymphocytes that are critical for the maintenance of self-tolerance. Expression levels of the transcription…”
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Response kinetics reveal novel features of ageing in murine T cells by Pieren, Daan K. J., Smits, Noortje A. M., van de Garde, Martijn D. B., Guichelaar, Teun

“…The impact of ageing on the immune system results in defects in T cell responsiveness. The search for ageing hallmarks has been challenging due to the complex…”
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Co-Expression of TIGIT and Helios Marks Immunosenescent CD8 + T Cells During Aging by Pieren, Daan K J, Smits, Noortje A M, Postel, Rimke J, Kandiah, Vinitha, de Wit, Jelle, van Beek, Josine, van Baarle, Debbie, Guichelaar, Teun

“…Aging leads to alterations in the immune system that result in ineffective responsiveness against pathogens. Features of this process, collectively known as…”
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Characteristics of RSV-Specific Maternal Antibodies in Plasma of Hospitalized, Acute RSV Patients under Three Months of Age by Jans, Jop, Wicht, Oliver, Widjaja, Ivy, Ahout, Inge M L, de Groot, Ronald, Guichelaar, Teun, Luytjes, Willem, de Jonge, Marien I, de Haan, Cornelis A M, Ferwerda, Gerben

“…Respiratory syncytial virus (RSV) is the leading cause for respiratory illness that requires hospitalization in infancy. High levels of maternal antibodies can…”
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Contribution of SARS-CoV-2 infection preceding COVID-19 mRNA vaccination to generation of cellular and humoral immune responses in children by Verheul, Marije K, Vos, Martijn, de Rond, Lia, De Zeeuw-Brouwer, Mary-Lène, Nijhof, Kim H, Smit, Debbie, Oomen, Debbie, Molenaar, Petra, Bogaard, Marjan, van Bergen, Rianne, Middelhof, Irene, Beckers, Lisa, Wijmenga-Monsuur, Alienke J, Buisman, Anne-Marie, Boer, Mardi C, van Binnendijk, Rob, de Wit, Jelle, Guichelaar, Teun

“…Primary COVID-19 vaccination for children, 5-17 years of age, was offered in the Netherlands at a time when a substantial part of this population had already…”
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Application of cultured human regulatory T cells requires preclinical in vivo evaluation by Vercoulen, Yvonne, PhD, Guichelaar, Teun, PhD, Meerding, Jenny, BAS, Emmelot, Maarten, BAS, Pingen, Marieke, MSc, Storm, Gert, PhD, Coffer, Paul, PhD, Sawitzki, Birgit, PhD, Martens, Anton, PhD, Mutis, Tuna, MD, PhD, Prakken, Berent, MD, PhD

“…The failure of iFOXP3+ T cells to control x-GvHD resulted in both high x-GvHD scores, including weight loss (Fig 2, B, and see Fig E2, A, in this article's…”
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Bone marrow provides an environment that prevents suppression of therapeutic graft-vs.-tumor immunity by regulatory T cells by Guichelaar, Teun, Mutis, Tuna

“…Regulatory T cells (Tregs) can prevent graft-vs.-host disease as induced by the infusion of donor lymphocytes to cancer patients, but often they also suppress…”
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Disruption of circadian rhythm by alternating light‐dark cycles aggravates atherosclerosis development in APOE3‐Leiden.CETP mice by Schilperoort, Maaike, Berg, Rosa, Bosmans, Laura A., Os, Bram W., Dollé, Martijn E. T., Smits, Noortje A. M., Guichelaar, Teun, Baarle, Debbie, Koemans, Lotte, Berbée, Jimmy F. P., Deboer, Tom, Meijer, Johanna H., Vries, Margreet R., Vreeken, Dianne, Gils, Janine M., Willems van Dijk, Ko, Kerkhof, Linda W. M., Lutgens, Esther, Biermasz, Nienke R., Rensen, Patrick C. N., Kooijman, Sander

“…Disruption of circadian rhythm by means of shift work has been associated with cardiovascular disease in humans. However, causality and underlying mechanisms…”
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Regulatory KIR+RA+ T cells accumulate with age and are highly activated during viral respiratory disease by Pieren, Daan K. J., Smits, Noortje A. M., Hoeboer, Jeroen, Kandiah, Vinitha, Postel, Rimke J., Mariman, Rob, Beek, Josine, Baarle, Debbie, Wit, Jelle, Guichelaar, Teun

“…Severe respiratory viral infectious diseases such as influenza and COVID‐19 especially affect the older population. This is partly ascribed to diminished CD8+…”
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In Vitro Enhancement of Respiratory Syncytial Virus Infection by Maternal Antibodies Does Not Explain Disease Severity in Infants by van Erp, Elisabeth A, van Kasteren, Puck B, Guichelaar, Teun, Ahout, Inge M L, de Haan, Cornelis A M, Luytjes, Willem, Ferwerda, Gerben, Wicht, Oliver

“…Respiratory syncytial virus (RSV) is the leading cause of severe respiratory illness in infants. At this young age, infants typically depend on maternally…”
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Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance by Pennings, Jeroen L. A., Mariman, Rob, Hodemaekers, Hennie M., Reemers, Sylvia S. N., Janssen, Riny, Guichelaar, Teun

“…Aging poses an increased risk of severe infection by respiratory syncytial virus (RSV). The many different biological pathways comprising the response to…”
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Diversity of aging of the immune system classified in the cotton rat (Sigmodon hispidus) model of human infectious diseases by Guichelaar, Teun, van Erp, Elisabeth A., Hoeboer, Jeroen, Smits, Noortje A.M., van Els, Cécile A.C.M., Pieren, Daan K.J., Luytjes, Willem

“…Susceptibility and declined resistance to human pathogens like respiratory syncytial virus (RSV) at old age is well represented in the cotton rat (Sigmodon…”
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Human regulatory T cells do not suppress the antitumor immunity in the bone marrow: a role for bone marrow stromal cells in neutralizing regulatory T cells by Guichelaar, Teun, Emmelot, Maarten E, Rozemuller, Henk, Martini, Bianka, Groen, Richard W J, Storm, Gert, Lokhorst, Henk M, Martens, Anton C, Mutis, Tuna

“…Regulatory T cells (Tregs) are potent tools to prevent graft-versus-host disease (GVHD) induced after allogeneic stem cell transplantation or donor lymphocyte…”
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Impaired immune response to vaccination against infection with human respiratory syncytial virus at advanced age by Guichelaar, Teun, Hoeboer, Jeroen, Widjojoatmodjo, Myra N, Reemers, Sylvia S N, van Els, Cécile A C M, Otten, Rob, van Remmerden, Yvonne, Boes, Jolande, Luytjes, Willem

“…Elderly humans are prone to severe infection with human respiratory syncytial virus (HRSV). The aging of today's human population warrants the development of…”
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Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness by Pieren, Daan K J, Smits, Noortje A M, Imholz, Sandra, Nagarajah, Bhawani, van Oostrom, Conny T, Brandt, Renata M C, Vermeij, Wilbert P, Dollé, Martijn E T, Guichelaar, Teun

“…Decline of immune function during aging has in part been ascribed to the accumulation of regulatory T cells (Tregs) and decreased T-cell responses with age…”
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Oral or Nasal Antigen Induces Regulatory T Cells That Suppress Arthritis and Proliferation of Arthritogenic T Cells in Joint Draining Lymph Nodes by Broere, Femke, Wieten, Lotte, Klein Koerkamp, Elles I, van Roon, Joel A. G, Guichelaar, Teun, Lafeber, Floris P. J. G, van Eden, Willem

“…The propagation of mucosal tolerance as a therapeutic approach in autoimmune diseases remains a difficult goal to achieve, and therefore further mechanistic…”
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Bone Marrow Neutralizes Human Regulatory T-Cells to Permit Graft-Versus-Tumor Immunity In Humanized Mice by Guichelaar, Teun, Rozemuller, Henk, Emmelot, Maarten, Martini, Bianka, Storm, Gert, Lokhorst, Henk M, Martens, Anton, Mutis, Tuna

“…Abstract 1017 While application of regulatory T-cells (Tregs) has become a promising tool to prevent Graft-versus-Host Disease (GvHD), Tregs pose the risk of…”
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Eradication of Medullary Multiple Myeloma by CD4+ Cytotoxic Human T Lymphocytes Directed at a Single Minor Histocompatibility Antigen by SPAAPEN, Robbert M, GROEN, Richard W. J, MUTIS, Tuna, VAN DEN OUDENALDER, Kelly, GUICHELAAR, Teun, VAN ELK, Maureen, AARTS-RIEMENS, Tineke, BLOEM, Andries C, STORM, Gert, MARTENS, Anton C, LOKHORST, Henk M

“…The essential role of CD4(+) T cells as helpers of anticancer immunity is indisputable. Little is known, however, about their capacity to serve as effector…”
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Autoantigen-Specific IL-10-Transduced T Cells Suppress Chronic Arthritis by Promoting the Endogenous Regulatory IL-10 Response by Guichelaar, Teun, ten Brink, Corlinda B, van Kooten, Peter J, Berlo, Suzanne E, Broeren, Chris P, van Eden, Willem, Broere, Femke

“…Deficient T cell regulation can be mechanistically associated with development of chronic autoimmune diseases. Therefore, combining the regulatory properties…”
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Increased efficacy of immersion vaccination in fish with hyperosmotic pretreatment by Huising, Mark O., Guichelaar, Teun, Hoek, Casper, Verburg-van Kemenade, B.M.Lidy, Flik, Gert, Savelkoul, Huub F.J., Rombout, Jan H.W.M.

“…Immersion vaccination is common practice in aquaculture, because of its convenience for mass vaccination with sufficient protection. However, the mechanisms of…”
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