Search Results - "GUENGERICH, F. Peter"

Mechanisms of Cytochrome P450-Catalyzed Oxidations by Guengerich, F. Peter

“…Enzymes are complex biological catalysts and are critical to life. Most oxidations of chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which…”
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Cytochrome P450 research and The Journal of Biological Chemistry by Guengerich, F. Peter

“…In honor of the 100th birthday of Dr. Herbert Tabor, JBC’s Editor-in-Chief for 40 years, I will review here JBC’s extensive coverage of the field of cytochrome…”
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Formation and Cleavage of C–C Bonds by Enzymatic Oxidation–Reduction Reactions by Guengerich, F. Peter, Yoshimoto, Francis K

“…Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions that make and break C–C bonds. The list includes cytochrome P450 and…”
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Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals by Rendic, Slobodan, Guengerich, F. Peter

“…Analyzing the literature resources used in our previous reports, we calculated the fractions of the oxidoreductase enzymes FMO (microsomal flavin-containing…”
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Drug Metabolism: A Half-Century Plus of Progress, Continued Needs, and New Opportunities by Guengerich, F Peter

“…The systematic study of drug metabolism began in the 19th Century, but most of what we know now has been learned in the last 50 years. Drug metabolism…”
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Recent Structural Insights into Cytochrome P450 Function by Guengerich, F. Peter, Waterman, Michael R, Egli, Martin

“…Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-soluble vitamins, carcinogens, pesticides, and many other types of…”
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A history of the roles of cytochrome P450 enzymes in the toxicity of drugs by Guengerich, F. Peter

“…The history of drug metabolism began in the 19th Century and developed slowly. In the mid-20th Century the relationship between drug metabolism and toxicity…”
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Introduction to Metals in Biology 2018: Copper homeostasis and utilization in redox enzymes by Guengerich, F. Peter

“…This 11th Thematic Metals in Biology Thematic Series deals with copper, a transition metal with a prominent role in biochemistry. Copper is a very versatile…”
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Unusual Cytochrome P450 Enzymes and Reactions by Guengerich, F. Peter, Munro, Andrew W.

“…Cytochrome P450 enzymes primarily catalyze mixed-function oxidation reactions, plus some reductions and rearrangements of oxygenated species, e.g…”
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Contributions of Human Enzymes in Carcinogen Metabolism by Rendic, Slobodan, Guengerich, F. Peter

“…Considerable support exists for the roles of metabolism in modulating the carcinogenic properties of chemicals. In particular, many of these compounds are…”
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Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development by Guengerich, F. Peter

“…Toxicity has been estimated to be responsible for the attrition of approximately one-third of drug candidates and is a major contributor to the high cost of…”
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The relationships between cytochromes P450 and H2O2: Production, reaction, and inhibition by Albertolle, Matthew E., Peter Guengerich, F.

“…In this review we address the relationship between cytochromes P450 (P450) and H2O2. This association can affect biology in three distinct ways. First, P450s…”
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Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update by Rendic, Slobodan P., Guengerich, F. Peter

“…This is an overview of the metabolic activation of drugs, natural products, physiological compounds, and general chemicals by the catalytic activity of…”
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Inhibition of Cytochrome P450 Enzymes by Drugs-Molecular Basis and Practical Applications by Guengerich, F Peter

“…Drug-drug interactions are a major cause of hospitalization and deaths related to drug use. A large fraction of these is due to inhibition of enzymes involved…”
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Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens by Peter Guengerich, F, Avadhani, Narayan G

“…Cytochrome P450 (P450) enzymes are involved in the metabolism of carcinogens, as well as drugs, steroids, vitamins, and other classes of chemicals. P450s also…”
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Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis by Hargrove, Tatiana Y., Friggeri, Laura, Wawrzak, Zdzislaw, Qi, Aidong, Hoekstra, William J., Schotzinger, Robert J., York, John D., Guengerich, F. Peter, Lepesheva, Galina I.

“…With some advances in modern medicine (such as cancer chemotherapy, broad exposure to antibiotics, and immunosuppression), the incidence of opportunistic…”
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Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions by Guengerich, F Peter

“…In the course of investigations of the kinetics of individual reactions of cytochrome P450 (P450) enzymes, a number of points about the complexity of P450…”
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Mechanism of the Third Oxidative Step in the Conversion of Androgens to Estrogens by Cytochrome P450 19A1 Steroid Aromatase by Yoshimoto, Francis K, Guengerich, F. Peter

“…Aromatase is the cytochrome P450 enzyme that cleaves the C10–C19 carbon–carbon bond of androgens to form estrogens, in a three-step process. Compound I (FeO3+)…”
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Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data by Kloudova-Spalenkova, Alzbeta, Ueng, Yune-Fang, Wei, Shouzou, Kopeckova, Katerina, Peter Guengerich, F., Soucek, Pavel

“…•Oxygenated cholesterol metabolites (oxysterols) can contribute to cancer progression.•Circulating levels of 7 oxysterols were assessed in luminal breast…”
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A requirement for an active proton delivery network supports a compound I-mediated C–C bond cleavage in CYP51 catalysis by Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Guengerich, F. Peter, Lepesheva, Galina I.

“…CYP51 enzymes (sterol 14α-demethylases) are cytochromes P450 that catalyze multistep reactions. The CYP51 reaction occurs in all biological kingdoms and is…”
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