Search Results - "GUDASHEVA, T. A"

Dimeric mimetic of BDNF loop 4 promotes survival of serum-deprived cell through TrkB-dependent apoptosis suppression by Zainullina, L. F., Vakhitova, Yu. V., Lusta, A. Yu, Gudasheva, T. A., Seredenin, S. B.

“…Brain-derived neurotrophic factor (BDNF) is involved in the regulation of neuronal cell growth, differentiation, neuroprotection and synaptic plasticity…”
Get full text

Anxiolytic Action of Dipeptide Mimetic of the BDNF Loop 2 in Adult Animals by Kolik, L. G., Nadorova, A. V., Grigorevskikh, E. M., Sazonova, N. M., Gudasheva, T. A.

“…We studied the anti-anxiety effect of a low-molecular-weight mimetic of the BDNF loop 2, hexamethylenediamide bis-(-N-hexanoyl-L-seryl-L-lysine) (GTS-201) in…”
Get full text

Analysis of the Role of PI3K/Akt Pathway in the Realization of the Normalizing Effect of Low-Molecular-Weight Mimetics of NGF and BDNF on Activity of Prooxidant and Antioxidant Systems in C57BL/6 Mice with Modeled Diabetes by Yagubova, S. S., Zolotov, N. N., Ostrovskaya, R. U., Gudasheva, T. A.

“…The effect of low-molecular-weight mimetics of NGF and BDNF (GK-2 and GSB-214 in a dose 0.5 mg/kg, respectively) on malondialdehyde content and activity of an…”
Get full text

Antidiabetic Effect of a New Original NT-3 Dipeptide Mimetic by Yagubova, S. S., Chernyshevskaya, M. A., Ostrovskaya, R. U., Gudasheva, T. A., Seredenin, S. B.

“…It was previously established that the original dipeptide mimetic of the 4th loop of NT-3, hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine)…”
Get full text

The Anxiolytic Effect of the Neuropeptide Cycloprolylglycine Is Mediated by AMPA and TrkB Receptors by Gudasheva, T. A., Povarnina, P. Yu, Koliasnikova, K. N., Alyaeva, A. G., Vorontsova, O. N., Seredenin, S. B.

“…Previously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the pharmacological…”
Get full text

Low-Molecular-Weight Perorally Active Nerve Growth Factor Mimetic Reduces Manifestations of Diabetic Neuropathy in Wistar Rats by Ivanov, S. V., Ostrovskaya, R. U., Khlybova, A. S., Gudasheva, T. A.

“…A low-molecular-weight nerve growth factor mimetic, compound GK-2 (bis-( N -monosuccinyl- L-glutamyl-L-lysine)hexamethylenediamide) that previously…”
Get full text

Pharmacogenetic Analysis of the Interaction of the Low-Molecular-Weight BDNF Mimetic Dipeptide GSB-106 with TRK Receptors by Antipova, T. A., Logvinov, I. O., Deyev, I. E., Povarnina, P. Yu, Vakhitova, Yu. V., Gudasheva, T. A., Seredenin, S. B.

“…Using TrkA or TrkB receptor gene knockout HT-22 cells, the selectivity of the interaction of the low-molecular-weight dipeptide BDNF mimetic GSB-106…”
Get full text

Neuroprotective Effect of the Neuropeptide Cycloprolylglycine Depends on AMPA- and TrkB-Receptor Activation by Gudasheva, T. A., Koliasnikova, K. N., Alyaeva, A. G., Nikolaev, S. V., Antipova, T. A., Seredenin, S. B.

“…Previously, we have shown that the endogenous neuropeptide cycloprolylglycine (CPG) is the positive modulator of AMPA receptors and revealed the dependence of…”
Get full text

The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties by Gudasheva, T. A., Sazonova, N. M., Tarasiuk, A. V., Logvinov, I. O., Antipova, T. A., Nikiforov, D. M., Povarnina, P. Yu, Seredenin, S. B.

“…The dimeric dipeptide mimetic hexamethylenediamide bis -( N -monosuccinyl- L -asparaginyl- L -asparagine) (GTS-301) was created on the basis of the structure…”
Get full text

Dipeptide Mimetics of Different NGF and BDNF Loops Activate PLC-γ1 by Gudasheva, T. A., Logvinov, I. O., Nikolaev, S. V., Antipova, T. A., Povarnina, P. Yu, Seredenin, S. B.

“…Previously, we designed and synthesized dipeptide mimetics of individual loops of the nerve growth factor (NGF) and the brain-derived neurotrophic factor…”
Get full text

Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells by Gudasheva, T. A., Koliasnikova, K. N., Antipova, T. A., Seredenin, S. B.

“…It was shown for the first time that the endogenous cyclic dipeptide cycloprolylglycine (CPG) at concentrations of 10 –7 and 10 –3 M and piracetam at a…”
Get full text

The first dipeptide ligand of translocator protein: Design and anxiolytic activity by Gudasheva, T. A., Deeva, O. A., Mokrov, G. V., Yarkov, S. A., Yarkova, M. A., Seredenin, S. B.

“…On the basis of the structure of Alpidem, a pyrazolopyrimidine ligand of the translocator protein (TSPO), a dipeptide TSPO ligand, N-carbobenzoxy- L…”
Get full text

Preclinical Pharmacokinetic and Pharmacodynamic Studies of Pharmaceutical Compositions of the Dipeptide Anxiolytic GB-115 by Zherdev, V. P., Boiko, S. S., Konstantinopol’skii, M. A., Raskin, S. Yu, Alekseev, K. V., Gudasheva, T. A., Mart’yanov, V. A., Kolik, L. G.

“…Four pharmaceutical compositions for oral use that contained the dipeptide anxiolytic GB-115 as the active ingredient underwent preclinical trials in male…”
Get full text

Neuroprotective Effects of Dipeptide Analogue of Brain-Derived Neurotrophic Factor GSB-106 in In Vitro Experiments by Logvinov, I. O., Antipova, T. A., Gudasheva, T. A, Tarasiuk, A. V., Antipov, P. I., Seredenin, S. B.

“…Dimeric dipeptide GSB-106, a novel structural analogue of neurotrophin BDNF, in doses from 10 −5 to 10 −8 M protected cultured immortalized mouse hippocampal…”
Get full text

Neuroprotective and Neuroregenerative Properties of Dimeric Dipeptide Mimetics of Individual NGF and BDNF Loops Under Conditions of an Experimental Ischemic Stroke Model by Povarnina, P. Yu, Antipova, T. A., Gudasheva, T. A., Seredenin, S. B.

“…This article reviews our work devoted to studying the biochemical properties of original dimeric dipeptide mimetics of nerve growth factor (NGF) and…”
Get full text

Effect of a Low-Molecular-Weight NGF Mimetic on a Combined High-Carbohydrate Diet/Streptozotocin-Induced Model of Type 2 Diabetes by Ivanov, S. V., Ostrovskaya, R. U., Demorzhi, M. S., Alchinova, I. B., Gudasheva, T. A.

“…Results of the antidiabetic activity of the low-molecular-weight NGF mimetic GK-2 [bis-( N -monosuccinylglutamyl- L -lysine) hexamethylenediamide] in a type 2…”
Get full text

Comparative Study of the Mnemotropic Activity of Dimeric Dipeptide Mimetics of Individual NGF and BDNF Loops Using a New-Object Recognition Test in Rats by Volkova, A. A., Povarnina, P. Yu, Nikiforov, D. M., Gudasheva, T. A., Seredenin, S. B.

“…It is well known that the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are involved in learning and memory. Specialists…”
Get full text

Dipeptide Ligands of TSPO by Deeva, O. A., Yarkova, M. A., Mokrov, G. V., Gudasheva, T. A., Seredenin, S. B.

“…Our own investigations of the synthesis and pharmacological properties of dipeptide ligands of the translocator protein (TSPO) are reviewed. The compounds were…”
Get full text

Dose-Dependent Effect of Nerve Growth Factor Mimetic GK-2 in a Wistar Rat Diabetes Model by Ivanov, S. V., Ostrovskaya, R. U., Gudasheva, T. A., Seredenin, S. B.

“…Experimental results for the new nerve growth factor (NGF) mimetic GK-2 [ bis -( N -monosuccinyl- L -glutamyl- L -lysine)hexamethylenediamide] administered…”
Get full text

Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides by Mokrov, G.V., Deeva, O.A., Gudasheva, T.A., Yarkov, S.A., Yarkova, M.A., Seredenin, S.B.

“…[Display omitted] A series of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides were designed and synthesized as 18kDa translocator protein (TSPO) ligands…”
Get full text