Search Results - "GUAZA, Carmen"

Therapeutic potential of extracellular vesicles derived from human mesenchymal stem cells in a model of progressive multiple sclerosis by Laso-García, Fernando, Ramos-Cejudo, Jaime, Carrillo-Salinas, Francisco Javier, Otero-Ortega, Laura, Feliú, Ana, Gómez-de Frutos, MariCarmen, Mecha, Miriam, Díez-Tejedor, Exuperio, Guaza, Carmen, Gutiérrez-Fernández, María

“…Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication and as possible therapeutic agents in inflammation-mediated…”
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The Dual PDE7-GSK3β Inhibitor, VP3.15, as Neuroprotective Disease-Modifying Treatment in a Model of Primary Progressive Multiple Sclerosis by Benítez-Fernández, Rocio, Gil, Carmen, Guaza, Carmen, Mestre, Leyre, Martínez, Ana

“…Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune and degenerative disease with axonal damage and demyelination as its main features. Its dual…”
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Selected Clostridia Strains from The Human Microbiota and their Metabolite, Butyrate, Improve Experimental Autoimmune Encephalomyelitis by Calvo-Barreiro, Laura, Eixarch, Herena, Cornejo, Thais, Costa, Carme, Castillo, Mireia, Mestre, Leyre, Guaza, Carmen, Martínez-Cuesta, María del Carmen, Tanoue, Takeshi, Honda, Kenya, González-López, Juan José, Montalban, Xavier, Espejo, Carmen

“…Summary Gut microbiome studies in multiple sclerosis (MS) patients are unravelling some consistent but modest patterns of gut dysbiosis. Among these, a…”
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Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis by Navarrete, Carmen, García-Martin, Adela, Garrido-Rodríguez, Martín, Mestre, Leyre, Feliú, Ana, Guaza, Carmen, Calzado, Marco A., Muñoz, Eduardo

“…Multiple Sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes in the spinal cord and the brain. Natural and…”
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A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis by Hernández-Torres, Gloria, Cipriano, Mariateresa, Hedén, Erika, Björklund, Emmelie, Canales, Ángeles, Zian, Debora, Feliú, Ana, Mecha, Miriam, Guaza, Carmen, Fowler, Christopher J., Ortega-Gutiérrez, Silvia, López-Rodríguez, María L.

“…Monoacylglycerol lipase (MAGL) is the enzyme responsible for the inactivation of the endocannabinoid 2‐arachidonoylglycerol (2‐AG). MAGL inhibitors show…”
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Perspectives on Cannabis-Based Therapy of Multiple Sclerosis: A Mini-Review by Mecha, Miriam, Carrillo-Salinas, Francisco J, Feliú, Ana, Mestre, Leyre, Guaza, Carmen

“…The consistency, efficacy, and safety of cannabis-based medicines have been demonstrated in humans, leading to the approval of the first cannabis-based therapy…”
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CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation by Hernangómez, Miriam, Mestre, Leyre, Correa, Fernando G., Loría, Frida, Mecha, Miriam, Iñigo, Paula M., Docagne, Fabian, Williams, Richard O., Borrell, José, Guaza, Carmen

“…The endocannabinoid anandamide (AEA) is released by macrophages and microglia on pathological neuroinflammatory conditions such as multiple sclerosis (MS)…”
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Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis by Mestre, Leyre, Carrillo-Salinas, Francisco Javier, Mecha, Miriam, Feliú, Ana, Espejo, Carmen, Álvarez-Cermeño, José Carlos, Villar, Luisa María, Guaza, Carmen

“…Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the…”
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Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis by Mecha, Miriam, Yanguas-Casás, Natalia, Feliú, Ana, Mestre, Leyre, Carrillo-Salinas, Francisco Javier, Riecken, Kristoffer, Gomez-Nicola, Diego, Guaza, Carmen

“…The participation of microglia in CNS development and homeostasis indicate that these cells are pivotal for the regeneration that occurs after demyelination…”
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2‐AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs by Mecha, Miriam, Feliú, Ana, Machín, Isabel, Cordero, Cesar, Carrillo‐Salinas, Francisco, Mestre, Leyre, Hernández‐Torres, Gloria, Ortega‐Gutiérrez, Silvia, López‐Rodríguez, María L, de Castro, Fernando, Clemente, Diego, Guaza, Carmen

“…The innate immune response is mediated by primary immune modulators such as cytokines and chemokines that together with immune cells and resident glia…”
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Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system by Hernangómez, Miriam, Carrillo-Salinas, Francisco J, Mecha, Miriam, Correa, Fernando, Mestre, Leyre, Loría, Frida, Feliú, Ana, Docagne, Fabian, Guaza, Carmen

“…The central nervous system (CNS) innate immune response includes an arsenal of molecules and receptors expressed by professional phagocytes, glial cells and…”
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Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy by Navarrete, Carmen, Carrillo-Salinas, Francisco, Palomares, Belén, Mecha, Miriam, Jiménez-Jiménez, Carla, Mestre, Leyre, Feliú, Ana, Bellido, Maria L, Fiebich, Bernd L, Appendino, Giovanni, Calzado, Marco A, Guaza, Carmen, Muñoz, Eduardo

“…Multiple sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes variously dominant in different stages of the…”
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A cannabigerol derivative suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis by Carrillo-Salinas, Francisco J, Navarrete, Carmen, Mecha, Miriam, Feliú, Ana, Collado, Juan A, Cantarero, Irene, Bellido, María L, Muñoz, Eduardo, Guaza, Carmen

“…Phytocannabinoids that do not produce psychotropic effects are considered of special interest as novel therapeutic agents in CNS diseases. A cannabigerol…”
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How oral probiotics affect the severity of an experimental model of progressive multiple sclerosis? Bringing commensal bacteria into the neurodegenerative process by Mestre, Leyre, Carrillo-Salinas, Francisco J., Feliú, Ana, Mecha, Miriam, Alonso, Graciela, Espejo, Carmen, Calvo-Barreiro, Laura, Luque-García, José L., Estevez, Héctor, Villar, Luisa María, Guaza, Carmen

“…A growing number of studies support that the bidirectional interactions between the gut microbiota, the immune system and the CNS are relevant for the…”
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CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model by Hernangómez, Miriam, Klusáková, Ilona, Joukal, Marek, Hradilová-Svíženská, Ivana, Guaza, Carmen, Dubový, Petr

“…Interaction of CD200 with its receptor CD200R has an immunoregulatory role and attenuates various types of neuroinflammatory diseases. Immunofluorescence…”
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A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis by Calvo-Barreiro, Laura, Eixarch, Herena, Ponce-Alonso, Manuel, Castillo, Mireia, Lebrón-Galán, Rafael, Mestre, Leyre, Guaza, Carmen, Clemente, Diego, Del Campo, Rosa, Montalban, Xavier, Espejo, Carmen

“…Previous studies in experimental autoimmune encephalomyelitis (EAE) models have shown that some probiotic bacteria beneficially impact the development of this…”
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The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: Evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells by Correa, Fernando, Hernangómez-Herrero, Miriam, Mestre, Leyre, Loría, Frida, Docagne, Fabian, Guaza, Carmen

“…Research highlights ► Anandamide downregulates IL-12p70 and IL-23 in TMEV-IDD influencing adaptive immunity. ► TMEV-infected microglia is a target for…”
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The endocannabinoid system is modulated in response to spinal cord injury in rats by Garcia-Ovejero, Daniel, Arevalo-Martin, Angel, Petrosino, Stefania, Docagne, Fabian, Hagen, Carlos, Bisogno, Tiziana, Watanabe, Masahiko, Guaza, Carmen, Di Marzo, Vincenzo, Molina-Holgado, Eduardo

“…Abstract Endocannabinoids are lipid mediators with protective effects in many diseases of the nervous system. We have studied the modulation of the…”
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Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide by Loría, Frida, Petrosino, Stefania, Mestre, Leyre, Spagnolo, Alessandra, Correa, Fernando, Hernangómez, Miriam, Guaza, Carmen, Di Marzo, Vincenzo, Docagne, Fabian

“…Cannabinoids have recently been approved as a treatment for pain in multiple sclerosis (MS). Increasing evidence from animal studies suggests that this class…”
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Activation of cannabinoid CB2 receptor negatively regulates IL‐12p40 production in murine macrophages: role of IL‐10 and ERK1/2 kinase signaling by Correa, Fernando, Mestre, Leyre, Docagne, Fabian, Guaza, Carmen

“…1 Cannabinoid (CB) receptor agonists have potential utility as anti‐inflammatory drugs for the treatment of many disease conditions. In the present study, we…”
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