Search Results - "GUARINI, Salvatore"

Multiple beneficial effects of melanocortin MC4 receptor agonists in experimental neurodegenerative disorders: Therapeutic perspectives by Giuliani, Daniela, Ottani, Alessandra, Neri, Laura, Zaffe, Davide, Grieco, Paolo, Jochem, Jerzy, Cavallini, Gian Maria, Catania, Anna, Guarini, Salvatore

“…Melanocortin peptides induce neuroprotection in acute and chronic experimental neurodegenerative conditions. Melanocortins likewise counteract systemic…”
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Corrigendum to “Modulation of the JAK/ERK/STAT signaling in melanocortin -induced inhibition of local and systemic responses to myocardial ischemia/reperfusion [Pharmacological Research 72 (2013) 1–8] by Ottani, Alessandra, Galantucci, Maria, Ardimento, Ettore, Neri, Laura, Canalini, Fabrizio, Calevro, Anita, Zaffe, Davide, Novellino, Ettore, Grieco, Paolo, Giuliani, Daniela, Guarini, Salvatore

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Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways by Giuliani, Daniela, Bitto, Alessandra, Galantucci, Maria, Zaffe, Davide, Ottani, Alessandra, Irrera, Natasha, Neri, Laura, Cavallini, Gian Maria, Altavilla, Domenica, Botticelli, Annibale R, Squadrito, Francesco, Guarini, Salvatore

“…Abstract Besides specific triggering causes, Alzheimer's disease (AD) involves pathophysiological pathways that are common to acute and chronic…”
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Beneficial Effects of Polydeoxyribonucleotide (PDRN) in an In Vitro Model of Fuchs Endothelial Corneal Dystrophy by Ceravolo, Ida, Mannino, Federica, Irrera, Natasha, Minutoli, Letteria, Arcoraci, Vincenzo, Altavilla, Domenica, Cavallini, Gian Maria, Guarini, Salvatore, Squadrito, Francesco, Pallio, Giovanni

“…Fuchs endothelial corneal dystrophy (FECD) is a bilateral, hereditary syndrome characterized by progressive irreversible injury in the corneal endothelium; it…”
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Up-regulation of the canonical Wnt-3A and Sonic hedgehog signaling underlies melanocortin-induced neurogenesis after cerebral ischemia by Spaccapelo, Luca, Galantucci, Maria, Neri, Laura, Contri, Miranda, Pizzala, Roberto, D'Amico, Roberto, Ottani, Alessandra, Sandrini, Maurizio, Zaffe, Davide, Giuliani, Daniela, Guarini, Salvatore

“…In experimental cerebral ischemia, melanocortin MC4 receptor agonists induce neuroprotection and neurogenesis with subsequent long-lasting functional recovery…”
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Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism by Ottani, Alessandra, Giuliani, Daniela, Galantucci, Maria, Spaccapelo, Luca, Novellino, Ettore, Grieco, Paolo, Jochem, Jerzy, Guarini, Salvatore

“…Recently we reported that an efferent vagal fibre-mediated cholinergic protective pathway, activated by melanocortins acting at brain melanocortin MC 3…”
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Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats by Mioni, Chiara, Bazzani, Carla, Giuliani, Daniela, Altavilla, Domenica, Leone, Sheila, Ferrari, Anna, Minutoli, Letteria, Bitto, Alessandra, Marini, Herbert, Zaffe, Davide, Botticelli, Annibale R, Iannone, Anna, Tomasi, Aldo, Bigiani, Albertino, Bertolini, Alfio, Squadrito, Francesco, Guarini, Salvatore

“…OBJECTIVE:A vagus nerve–mediated, brain cholinergic protective mechanism activated by melanocortin peptides is operative in conditions of circulatory shock;…”
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Effects of aglycone genistein in a rat experimental model of postmenopausal metabolic syndrome by Bitto, Alessandra, Altavilla, Domenica, Bonaiuto, Antonio, Polito, Francesca, Minutoli, Letteria, Di Stefano, Vincenzo, Giuliani, Daniela, Guarini, Salvatore, Arcoraci, Vincenzo, Squadrito, Francesco

“…Genistein aglycone, a soy derived isoflavone, has been demonstrated to be effective in reducing cardiovascular risk in postmenopausal women. We therefore…”
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Protective effect of melanocortin peptides in rat myocardial ischemia by Bazzani, C, Guarini, S, Botticelli, A R, Zaffe, D, Tomasi, A, Bini, A, Cainazzo, M M, Ferrazza, G, Mioni, C, Bertolini, A

“…The influence of the melanocortin peptide ACTH-(1-24) (adrenocorticotropin) on the consequences of short-term coronary ischemia (5 min) followed by…”
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Hydrogen sulfide slows down progression of experimental Alzheimer’s disease by targeting multiple pathophysiological mechanisms by Giuliani, Daniela, Ottani, Alessandra, Zaffe, Davide, Galantucci, Maria, Strinati, Flavio, Lodi, Renzo, Guarini, Salvatore

“…[Display omitted] •We found that hydrogen sulfide supply improves cognitive functions in three animal models of Alzheimer’s disease.•These effects are…”
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Retracted: Vagus Nerve Mediates the Protective Effects of Melanocortins against Cerebral and Systemic Damage after Ischemic Stroke by Ottani, Alessandra, Giuliani, Daniela, Mioni, Chiara, Galantucci, Maria, Minutoli, Letteria, Bitto, Alessandra, Altavilla, Domenica, Zaffe, Davide, Botticelli, Annibale R, Squadrito, Francesco, Guarini, Salvatore

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Lipid peroxidation triggers both c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) activation and neointimal hyperplasia induced by cessation of blood flow in the mouse carotid artery by Squadrito, Francesco, Minutoli, Letteria, Esposito, Maria, Bitto, Alessandra, Marini, Herbert, Seminara, Paolo, Crisafulli, Alessandra, Passaniti, Mariolina, Adamo, Elena Bianca, Marini, Rolando, Guarini, Salvatore, Altavilla, Domenica

“…We investigated whether lipid peroxidation might influence activation of the mitogen activated protein kinase (MAPK) extracellular regulated kinase (ERK1/2)…”
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A highly reproducible model of arterial thrombosis in rats by Guarini, Salvatore

“…The objective of this investigation was to develop a reproducible and reliable method of arterial thrombosis in a small laboratory animal. Rats were…”
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Evidence that melanocortin 4 receptor mediates hemorrhagic shock reversal caused by melanocortin peptides by Guarini, S, Bazzani, C, Cainazzo, M M, Mioni, C, Ferrazza, G, Vergoni, A V, Schiöth, H B, Wikberg, J E, Bertolini, A

“…Melanocortin peptides are known to be extremely potent in causing the sustained reversal of different shock conditions, both in experimental animals and…”
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Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer's Disease in Transgenic Mice at Different Ages by Vandini, Eleonora, Ottani, Alessandra, Zaffe, Davide, Calevro, Anita, Canalini, Fabrizio, Cavallini, Gian Maria, Rossi, Rosario, Guarini, Salvatore, Giuliani, Daniela

“…Backgroud: Alzheimer disease is an age-related severe neurodegenerative pathology. The level of the third endogenous gas, hydrogen sulfide (H2S), is decreased…”
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NDP-α-MSH induces intense neurogenesis and cognitive recovery in Alzheimer transgenic mice through activation of melanocortin MC4 receptors by Giuliani, Daniela, Neri, Laura, Canalini, Fabrizio, Calevro, Anita, Ottani, Alessandra, Vandini, Eleonora, Sena, Paola, Zaffe, Davide, Guarini, Salvatore

“…Melanocortins exert neuroprotection in a variety of experimental neurodegenerative disorders, including Alzheimer's disease (AD). Further, in previous research…”
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Adrenocorticotropin reverses vascular dysfunction and protects against splanchnic artery occlusion shock by Squadrito, Francesco, Guarini, Salvatore, Altavilla, Domenica, Squadrito, Giovanni, Campo, Giuseppe M, Arlotta, Mariarita, Quartarone, Cristina, Saitta, Antonino, Cucinotta, Domenico, Bazzani, Carla, Cainazzo, Maria M, Mioni, Chiara, Bertolini, Alfio, Caputi, Achille P

“…Tumour necrosis factor (TNF‐α) is involved in the pathogenesis of splanchnic artery occlusion (SAO) shock. On the other hand, inhibition of TNF‐α is an…”
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Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice by Bitto, Alessandra, Giuliani, Daniela, Pallio, Giovanni, Irrera, Natasha, Vandini, Eleonora, Canalini, Fabrizio, Zaffe, Davide, Ottani, Alessandra, Minutoli, Letteria, Rinaldi, Mariagrazia, Guarini, Salvatore, Squadrito, Francesco, Altavilla, Domenica

“…Objective and design Alzheimer’s disease (AD) is associated with amyloid plaques (Aβ) and hyperphosphorylated tau protein tangles in the brain. We investigated…”
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Protective effects of the melanocortin analog NDP-α-MSH in rats undergoing cardiac arrest by Ottani, Alessandra, Neri, Laura, Canalini, Fabrizio, Calevro, Anita, Rossi, Rosario, Cappelli, Gianni, Ballestri, Marco, Giuliani, Daniela, Guarini, Salvatore

“…We previously reported that melanocortins afford cardioprotection in conditions of experimental myocardial ischemia/reperfusion, with involvement of the janus…”
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Melanocortin Receptor-4 and Glioblastoma Cells: Effects of the Selective Antagonist ML00253764 Alone and in Combination with Temozolomide In Vitro and In Vivo by Vaglini, Francesca, Pardini, Carla, Di Desidero, Teresa, Orlandi, Paola, Pasqualetti, Francesco, Ottani, Alessandra, Pacini, Simone, Giuliani, Daniela, Guarini, Salvatore, Bocci, Guido

“…Currently, no description of melanocortin receptor-4 (MC4R) expression or activity is available in human cancer cells, including glioblastoma (GBM). The aim of…”
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