Search Results - "GUANSHAN ZHU"

EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples by Ellison, Gillian, Zhu, Guanshan, Moulis, Alexandros, Dearden, Simon, Speake, Georgina, McCormack, Rose

“…Activating mutations in the gene encoding epidermal growth factor receptor (EGFR) can confer sensitivity to EGFR tyrosine kinase inhibitors such as gefitinib…”
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Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non―Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models by JINGCHUAN ZHANG, LIN ZHANG, ZHENGWEI DONG, GUANSHAN ZHU, ZILIANG QIAN, LILI TANG, PING ZHAN, QUNSHENG JI, KILGOUR, Elaine, SMITH, Paul D, NIGEL BROOKS, A, THOMAS, Roman K, XINYING SU, GAVINE, Paul R, MING LI, LIANG XIE, MALCHERS, Florian, SHUQIONG FAN, XIAOLU YIN, YANPING XU, KUNJI LIU

“…To investigate the incidence of FGFR1 amplification in Chinese non-small cell lung cancer (NSCLC) and to preclinically test the hypothesis that the novel,…”
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Serotonin Transporter Promoter Gain-of-Function Genotypes Are Linked to Obsessive-Compulsive Disorder by Hu, Xian-Zhang, Lipsky, Robert H., Zhu, Guanshan, Akhtar, Longina A., Taubman, Julie, Greenberg, Benjamin D., Xu, Ke, Arnold, Paul D., Richter, Margaret A., Kennedy, James L., Murphy, Dennis L., Goldman, David

“…A functional serotonin transporter promoter polymorphism, HTTLPR, alters the risk of disease as well as brain morphometry and function. Here, we show that…”
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Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma by Dong, Hua, Zhang, Lan, Qian, Ziliang, Zhu, Xuehua, Zhu, Guanshan, Chen, Yunqin, Xie, Xiaoying, Ye, Qinghai, Zang, Jie, Ren, Zhenggang, Ji, Qunsheng

“…To gain molecular insights of HBV integration that may contribute to HCC tumorigenesis, we performed whole transcriptome sequencing and whole genome copy…”
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Genetic variation in human NPY expression affects stress response and emotion by Stohler, Christian S, Zhou, Zhifeng, Hodgkinson, Colin A, Hauger, Richard L, Enoch, Mary-Anne, Ferrell, Robert E, Brown, Sarah M, Hariri, Ahmad R, Yuan, Qiaoping, Goldman, David, Hu, Xian-Zhang, Shen, Pei-Hong, Sinha, Rajita, Lipsky, Robert H, Xu, Ke, Scott, David, Virkkunen, Matti, Mash, Deborah C, Zubieta, Jon-Kar, Buzas, Beata, Manuck, Stephen B, Zhu, Guanshan

“…Understanding inter-individual differences in stress response requires the explanation of genetic influences at multiple phenotypic levels, including complex…”
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Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets by Qian, Ziliang, Zhu, Guanshan, Tang, Lili, Wang, Mei, Zhang, Lianhai, Fu, Jiangang, Huang, Chunlei, Fan, Shuqiong, Sun, Yun, Lv, Jing, Dong, Hua, Gao, Beirong, Su, Xinying, Yu, Dehua, Zang, Jie, Zhang, Xiaolin, Ji, Jiafu, Ji, Qunsheng

“…Gastric cancer is the second leading cause of death from cancer worldwide, with an approximately 20% 5‐year survival rate. To identify molecular subtypes…”
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Multigene PCR using both cfDNA and cfRNA in the supernatant of pleural effusion achieves accurate and rapid detection of mutations and fusions of driver genes in patients with advanced NSCLC by Chen, Xuejing, Li, Kun, Liu, Zichen, Gai, Fei, Zhu, Guanshan, Lu, Shun, Che, Nanying

“…Background Pleural effusion from patients with advanced non‐small cell lung cancer (NSCLC) has been proved valuable for molecular analysis, especially when the…”
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Malignant pleural effusion supernatants are substitutes for metastatic pleural tumor tissues in EGFR mutation test in patients with advanced lung adenocarcinoma by Liu, Dan, Lu, Yachao, Hu, Zhenli, Wu, Ning, Nie, Xiaomeng, Xia, Yang, Han, Yiping, Li, Qiang, Zhu, Guanshan, Bai, Chong

“…Though the possibility of using malignant pleural effusions (MPEs) as alternatives for metastatic pleural tumor tissues (MPTTs) in epidermal growth factor…”
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Recurrent amplification of MYC and TNFRSF11B in 8q24 is associated with poor survival in patients with gastric cancer by Wang, Xiaohong, Liu, Yiqiang, Shao, Duanfang, Qian, Ziliang, Dong, Zhengwei, Sun, Yun, Xing, Xiaofang, Cheng, Xiaojing, Du, Hong, Hu, Ying, Li, Yingai, Li, Lin, Dong, Bin, Li, Ziyu, Wu, Aiwen, Wu, Xiaojiang, Bu, Zhaode, Zong, Xianglong, Zhu, Guanshan, Ji, Qunsheng, Wen, Xian-zi, Zhang, Lian-hai, Ji, Jia-fu

“…Background Gastric cancer (GC) is an aggressive malignancy whose mechanisms of development and progression are poorly understood. The identification of…”
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Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models by Wu, Xianhua, Zhang, Jingchuan, Zhen, Ruheng, Lv, Jing, Zheng, Li, Su, Xinying, Zhu, Guanshan, Gavine, Paul R, Xu, Songtao, Lu, Shaohua, Hou, Jun, Liu, Yalan, Xu, Chen, Tan, Yunshan, Xie, Liang, Yin, Xiaolu, He, Deming, Ji, Qunsheng, Hou, Yingyong, Ge, Di

“…Trastuzumab is currently approved for the clinical treatment of breast and gastric cancer patients with HER-2 positive tumors, but not yet for the treatment of…”
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Sputum cell‐free DNA: Valued surrogate sample for the detection of EGFR exon 20 p.T790M mutation in patients with advanced lung adenocarcinoma and acquired resistance to EGFR‐TKIs by Wang, Zheng, Li, Xiaoguang, Zhang, Lin, Xu, Yan, Wang, Mengzhao, Liang, Li, Jiao, Peng, Li, Yuanming, He, Shurong, Du, Jun, He, Lei, Tang, Min, Sun, Mingjun, Yang, Li, Di, Jing, Zhu, Guanshan, Li, Lin, Liu, Dongge

“…Background Sputum cell‐free DNA (cfDNA) is a valuable surrogate sample for assessing EGFR‐sensitizing mutations in patients with advanced lung adenocarcinoma…”
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An evaluation and recommendation of the optimal methodologies to detect RET gene rearrangements in papillary thyroid carcinoma by Zhang, Tianwei, Lu, Yachao, Ye, Qingqing, Zhang, Meizhuo, Zheng, Li, Yin, Xiaolu, Gavine, Paul, Sun, Zhongsheng, Ji, Qunsheng, Zhu, Guanshan, Su, Xinying

“…To recommend a reliable and clinically realistic RET/PTC rearrangement detection assay for papillary thyroid carcinoma (PTC), we compared multiplex…”
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Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer by Yunxia, Zuo, Jun, Cao, Guanshan, Zhu, Yachao, Lu, Xueke, Zhou, Jin, Li

“…Doc number: 95…”
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Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer by Yunxia, Zuo, Jun, Cao, Guanshan, Zhu, Yachao, Lu, Xueke, Zhou, Jin, Li

“…Mutations of EGFR and K-ras are biomarkers for predicting the efficacy of targeting agents in non-small-cell lung cancer (NSCLC) and colorectal cancer (CRC)…”
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A modified extraction method of circulating free DNA for epidermal growth factor receptor mutation analysis by Yuan, Haihua, Zhu, Zhong-Zheng, Lu, Yachao, Liu, Feng, Zhang, Wenying, Huang, Gang, Zhu, Guanshan, Jiang, Bin

“…Circulating free DNA (cfDNA) in plasma is promising to be a surrogate for tumor tissue DNA. However, not all epidermal growth factor receptor (EGFR) mutations…”
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A Novel Single Nucleotide Polymorphism of the Neuropeptide Y (NPY) Gene Associated With Alcohol Dependence by Mottagui-Tabar, Salim, Prince, Jonathan A., Wahlestedt, Claes, Zhu, Guanshan, Goldman, David, Heilig, Markus

“…Background: Neuropeptide Y (NPY) is a major endogenous regulator of anxiety‐related behaviors and emotionality. Transgenic work with NPY and null‐mutant mice…”
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AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3‐kinase‐dependent activation in extracellular signal‐regulated kinase to upregulate BDNF gene expression by Wu, Xuan, Zhu, Daming, Jiang, Xueying, Okagaki, Peter, Mearow, Karen, Zhu, Guanshan, McCall, Sherman, Banaudha, Krishna, Lipsky, Robert H., Marini, Ann M.

“…The signal transduction and molecular mechanisms underlying α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionate (AMPA)‐mediated neuroprotection are unknown. In…”
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Association of the TP53 Codon 72 Polymorphism with Colorectal Cancer in a Chinese Population by Zhu, Zhong-Zheng, Wang, Ai-Zhong, Jia, Hang-Ruo, Jin, Xia-Xiang, He, Xiang-Lei, Hou, Li-Fang, Zhu, Guanshan

“…A TP53 gene polymorphism, resulting in an arginine (R) to proline (P) at codon 72 (TP53 R72P), has been associated with the susceptibility to various cancers…”
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NPY leu7pro and Alcohol Dependence in Finnish and Swedish Populations by Zhu, Guanshan, Pollak, Lotta, Mottagui-Tabar, Salim, Wahlestedt, Claes, Taubman, Julie, Virkkunen, Matti, Goldman, David, Heilig, Markus

“…Background: Neuropeptide Y (NPY) is a modulator of alcohol intake in animal models of alcoholism, and is potentially involved in alcohol dependence. A coding…”
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Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay by GUANSHAN ZHU, LIPSKY, Robert H, KE XU, ALI, Sameer, HYDE, Thomas, KLEINMAN, Joel, AKHTAR, Longina A, MASH, Deborah C, GOLDMAN, David

“…A common polymorphism, Val158Met, alters catechol- O-methyltransferase (COMT) enzyme activity and has been linked to psychiatric phenotypes. Bray et al. (2003)…”
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