Search Results - "GUANLAN XU"

Thioredoxin-interacting protein regulates insulin transcription through microRNA-204 by Xu, Guanlan, Chen, Junqin, Jing, Gu, Shalev, Anath

“…Thioredoxin-interacting protein (TXNIP) regulates the redox potential of cells and has previously been found to be upregulated in diabetic states. In a new…”
Get full text

Preventing β-Cell Loss and Diabetes With Calcium Channel Blockers by GUANLAN XU, JUNQIN CHEN, GU JING, SHALEV, Anath

“…Although loss of functional β-cell mass is a hallmark of diabetes, no treatment approaches that halt this process are currently available. We recently…”
Get full text

Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes by Xu, Guanlan, Grimes, Tiffany D., Grayson, Truman B., Chen, Junqin, Thielen, Lance A., Tse, Hubert M., Li, Peng, Kanke, Matt, Lin, Tai-Tu, Schepmoes, Athena A., Swensen, Adam C., Petyuk, Vladislav A., Ovalle, Fernando, Sethupathy, Praveen, Qian, Wei-Jun, Shalev, Anath

“…Currently, no oral medications are available for type 1 diabetes (T1D). While our recent randomized placebo-controlled T1D trial revealed that oral verapamil…”
Get full text

miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function by Jo, SeongHo, Chen, Junqin, Xu, Guanlan, Grayson, Truman B, Thielen, Lance A, Shalev, Anath

“…Glucagon-like peptide 1 receptor (GLP1R) agonists are widely used to treat diabetes. However, their function is dependent on adequate GLP1R expression, which…”
Get full text

MicroRNA-200 Is Induced by Thioredoxin-interacting Protein and Regulates Zeb1 Protein Signaling and Beta Cell Apoptosis by Filios, Stephen R., Xu, Guanlan, Chen, Junqin, Hong, Kyunghee, Jing, Gu, Shalev, Anath

“…Small noncoding microRNAs have emerged as important regulators of cellular processes, but their role in pancreatic beta cells has only started to be…”
Get full text

Thioredoxin-Interacting Protein Stimulates Its Own Expression via a Positive Feedback Loop by Chen, Junqin, Jing, Gu, Xu, Guanlan, Shalev, Anath

“…Thioredoxin-interacting protein (TXNIP) has emerged as a key regulator of important cellular processes including redox state, inflammation, and apoptosis and…”
Get full text

Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop by Jing, Gu, Chen, Junqin, Xu, Guanlan, Shalev, Anath

“…Abstract Objective Carbohydrate-response element-binding protein (ChREBP) is the major transcription factor conferring glucose-induced gene expression in…”
Get full text

Thioredoxin-interacting Protein Promotes Islet Amyloid Polypeptide Expression through miR-124a and FoxA2 by Jing, Gu, Westwell-Roper, Clara, Chen, Junqin, Xu, Guanlan, Verchere, C. Bruce, Shalev, Anath

“…Thioredoxin-interacting protein (TXNIP) is up-regulated by glucose and diabetes and plays a critical role in glucotoxicity, inflammation, and beta-cell…”
Get full text

Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes by Cha-Molstad, Hyunjoo, Xu, Guanlan, Chen, Junqin, Jing, Gu, Young, Martin E, Chatham, John C, Shalev, Anath

“…First-generation calcium channel blockers such as verapamil are a widely used class of antihypertensive drugs that block L-type calcium channels. We recently…”
Get more information

Verapamil and beta cell function in adults with recent-onset type 1 diabetes by Ovalle, Fernando, Grimes, Tiffany, Xu, Guanlan, Patel, Anish J., Grayson, Truman B., Thielen, Lance A., Li, Peng, Shalev, Anath

“…Pancreatic beta cell loss is a key factor in the pathogenesis of type 1 diabetes (T1D), but therapies to halt this process are lacking. We previously reported…”
Get full text

Expanding G-Theory Models to Incorporate Congeneric Relationships: Illustrations Using the Big Five Inventory by Vispoel, Walter P., Xu, Guanlan, Kilinc, Murat

“…We used structural equation modeling techniques to expand traditional generalizability theory (G-theory) models to allow for congeneric relationships among…”
Get full text

Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling by Xu, Guanlan, Chen, Junqin, Lu, Brian, Sethupathy, Praveen, Qian, Wei-Jun, Shalev, Anath

“…Verapamil promotes functional β-cell mass and improves glucose homeostasis in diabetic mice and humans with type 1 diabetes (T1D). Now, our global proteomics…”
Get full text

FOXO1 Competes with Carbohydrate Response Element-binding Protein (ChREBP) and Inhibits Thioredoxin-interacting Protein (TXNIP) Transcription in Pancreatic Beta Cells by Kibbe, Carly, Chen, Junqin, Xu, Guanlan, Jing, Gu, Shalev, Anath

“…Thioredoxin-interacting protein (TXNIP) has emerged as an important factor in pancreatic beta cell biology, and tight regulation of TXNIP levels is necessary…”
Get full text

Interrelationships Between Latent State-Trait Theory and Generalizability Theory Within a Structural Equation Modeling Framework by Vispoel, Walter P., Xu, Guanlan, Schneider, Wei S.

“…Over recent years, latent state-trait theory (LST) and generalizability theory (GT) have been applied to a wide variety of situations in numerous disciplines…”
Get full text

Human Glucagon Expression Is under the Control of miR-320a by Jo, SeongHo, Xu, Guanlan, Jing, Gu, Chen, Junqin, Shalev, Anath

“…Increased glucagon is a hallmark of diabetes and leads to worsening of the hyperglycemia, but the molecular mechanisms causing it are still unknown. We…”
Get full text

miR-204 Targets PERK and Regulates UPR Signaling and β-Cell Apoptosis by Xu, Guanlan, Chen, Junqin, Jing, Gu, Grayson, Truman B, Shalev, Anath

“…Endoplasmic reticulum (ER) stress plays an important role in the pathogenesis of diabetes and the associated β-cell apoptosis. Although microRNAs (miRNAs) have…”
Get full text

Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and Hyperglucagonemia by Lu, Brian, Chen, Junqin, Xu, Guanlan, Grayson, Truman B, Jing, Gu, Jo, Seong Ho, Shalev, Anath

“…Thioredoxin-interacting protein (TXNIP) has emerged as a key factor in pancreatic beta cell biology, and its upregulation by glucose and diabetes contributes…”
Get full text

Using Parallel Splits with Self-Report and Other Measures to Enhance Precision in Generalizability Theory Analyses by Vispoel, Walter P., Xu, Guanlan, Schneider, Wei S.

“…Although generalizability theory (G-theory) provides indices of reliability that take multiple sources of measurement error into account, those indices are…”
Get full text

Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways by Hong, Kyunghee, Xu, Guanlan, Grayson, Truman B., Shalev, Anath

“…Thioredoxin-interacting protein (TXNIP) is a key regulator of diabetic β-cell apoptosis and dysfunction, and TXNIP inhibition prevents diabetes in mouse models…”
Get full text

Expanding Bifactor Models of Psychological Traits to Account for Multiple Sources of Measurement Error by Vispoel, Walter P., Lee, Hyeryung, Xu, Guanlan, Hong, Hyeri

“…Over the last decade, applications of bifactor modeling within clinical settings have increased markedly but typically rely on data collected on single…”
Get full text