Search Results - "GUANHUA RAO"

Circulating tumor DNA functions as an alternative for tissue to overcome tumor heterogeneity in advanced gastric cancer by Gao, Jing, Wang, Haixing, Zang, Wanchun, Li, Beifang, Rao, Guanhua, Li, Lei, Yu, Yang, Li, Zhongwu, Dong, Bin, Lu, Zhihao, Jiang, Zhi, Shen, Lin

“…Overcoming tumor heterogeneity is a major challenge for personalized treatment of gastric cancer, especially for human epidermal growth factor receptor‐2…”
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Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer by Kim, In-Kyu, McCutcheon, Justine N., Rao, Guanhua, Liu, Stephen V., Pommier, Yves, Skrzypski, Marcin, Zhang, Yu-Wen, Giaccone, Giuseppe

“…Resistance to chemotherapy remains a critical barrier to effective cancer treatment. Although cisplatin is one of the most commonly used chemotherapeutic…”
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High utility of bronchoalveolar lavage fluid metagenomic next-generation sequencing approach for etiological diagnosis of pneumonia by Jiang, Lingyu, Han, Lin, Zhong, Yonglong, Zhang, Meng, Li, Jianliang, Rao, Guanhua, Xiang, Shulin

“…For patients with pneumonia, the rapid detection of pathogens is still a major global problem in clinical practice because traditional diagnostic techniques…”
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Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations by Rao, Guanhua, Pierobon, Mariaelena, Kim, In-Kyu, Hsu, Wei-Hsun, Deng, Jianghong, Moon, Yong-Wha, Petricoin, Emanuel F., Zhang, Yu-Wen, Wang, Yisong, Giaccone, Giuseppe

“…Accumulating evidence supports a role of the PI3K-AKT pathway in the regulation of cell motility, invasion and metastasis. AKT activation is known to promote…”
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Application of metagenomic next-generation sequencing in the clinical diagnosis of infectious diseases after allo-HSCT: a single-center analysis by Yuan, Hailong, Ma, Xiaolu, Xu, Jianli, Han, Peng, Rao, Guanhua, Chen, Gang, Zhang, Kaile, Yang, Ruixue, Han, Chuixia, Jiang, Ming

“…We investigated the value of metagenomic next-generation sequencing (mNGS) in diagnosing infectious diseases in patients receiving allogeneic hematopoietic…”
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Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer by Rao, Guanhua, Wang, Hongyi, Li, Baowei, Huang, Li, Xue, Danfeng, Wang, Xiaohui, Jin, Haijing, Wang, Jun, Zhu, Yushan, Lu, Youyong, Du, Lei, Chen, Quan

“…CD44 is of functional importance for tumor initiation and progression in colorectal cancer, but how this molecule benefits cancer cells from the tumor…”
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CD44-Positive Cancer Stem Cells Expressing Cellular Prion Protein Contribute to Metastatic Capacity in Colorectal Cancer by LEI DU, GUANHUA RAO, HONGMIN LIU, XIN SUN, YUSHAN ZHU, TANG, Dean G, MEHRPOUR, Maryam, YOUYONG LU, QUAN CHEN, HONGYI WANG, BAOWEI LI, WEILI TIAN, JIANTAO CUI, LEYA HE, LAFFIN, Brian, XIUYUN TIAN, CHUNYI HAO

“…Cancer stem cells are implicated in tumor progression, metastasis, and recurrence, although the exact mechanisms remain poorly understood. Here, we show that…”
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PI3K as a Potential Therapeutic Target in Thymic Epithelial Tumors by Alberobello, Anna Teresa, Wang, Yisong, Beerkens, Frans Joseph, Conforti, Fabio, McCutcheon, Justine N, Rao, Guanhua, Raffeld, Mark, Liu, Jing, Rahhal, Raneen, Zhang, Yu-Wen, Giaccone, Giuseppe

“…Thymic epithelial tumors (TETs) are rare tumors originating from the epithelium of the thymus with limited therapeutic options beyond surgery. The pathogenesis…”
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Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease by Song, Pingping, Li, Shanshan, Wu, Hao, Gao, Ruize, Gao, Ruize, Rao, Guanhua, Wang, Dongmei, Chen, Ziheng, Ma, Biao, Wang, Hongxia, Sui, Nan, Deng, Haiteng, Zhang, Zhuohua, Tang, Tieshan, Tan, Zheng, Han, Zehan, Lu, Tieyuan, Zhu, Yushan, Chen, Quan

“…Mutations or inactivation of parkin, an E3 ubiquitin ligase, are associated with familial form or sporadic Parkinson’s disease (PD), respectively, which…”
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Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors by Conforti, Fabio, Zhang, Xu, Rao, Guanhua, De Pas, Tommaso, Yonemori, Yoko, Rodriguez, Jose Antonio, McCutcheon, Justine N, Rahhal, Raneen, Alberobello, Anna T, Wang, Yisong, Zhang, Yu-Wen, Guha, Udayan, Giaccone, Giuseppe

“…Exportin 1 (XPO1) mediates nuclear export of many cellular factors known to play critical roles in malignant processes, and selinexor (KPT-330) is the first…”
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Dysbiosis of lower respiratory tract microbiome are associated with proinflammatory states in non‐small cell lung cancer patients by Li, Yangqian, Rao, Guanhua, Zhu, Guonian, Cheng, Cheng, Yuan, Lijuan, Li, Chengpin, Gao, Jianpeng, Tang, Jun, Wang, Zhoufeng, Li, Weimin

“…Background The lung has a sophisticated microbiome, and respiratory illnesses are greatly influenced by the lung microbiota. Despite the fact that numerous…”
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RAS/BRAF Circulating Tumor DNA Mutations as a Predictor of Response to First-Line Chemotherapy in Metastatic Colorectal Cancer Patients by Yan, Rui, Yu, Yang, Jin, Mulan, Cheng, Gang, An, Guangyu, Jiang, Zhi, Rao, Guanhua, Li, Lei, Yu, Pan, Weygant, Nathaniel, Ge, Yang, Zang, Wanchun, Yao, Jiannan, He, Linjia

“…Background. Since circulating tumor DNA (ctDNA) offers clear advantages as a minimally invasive method for tumor monitoring compared with tumor tissue, we…”
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Morphine induces Beclin 1- and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus by Zhao, Lixia, Zhu, Yushan, Wang, Dongmei, Chen, Ming, Gao, Ping, Xiao, Weiming, Rao, Guanhua, Wang, Xiaohui, Jin, Haijing, Xu, Lin, Sui, Nan, Chen, Quan

“…Chronic exposure to morphine can induce drug addiction and neural injury, but the exact mechanism is not fully understood. Here we show that morphine induces…”
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A commentary on “The efficacy and safety of probiotics for patients with constipation predominant irritable bowel syndrome: A systematic review and meta-analysis based on seventeen randomized controlled trials” [Int. J. Surg. 2020; 79: 111–119] by Rao, Guanhua, Meng, Zhijian

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Machine learning-based colistin resistance marker screening and phenotype prediction in Escherichia coli from whole genome sequencing data by Tian, Yingxin, Zhang, Di, Chen, Fangyuan, Rao, Guanhua, Zhang, Ying

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Prediction of antimicrobial resistance in Klebsiella pneumoniae using genomic and metagenomic next-generation sequencing data by Zhou, Xun, Yang, Ming, Chen, Fangyuan, Wang, Leilei, Han, Peng, Jiang, Zhi, Shen, Siquan, Rao, Guanhua, Yang, Fan

“…Abstract Objectives Klebsiella pneumoniae is a significant pathogen with increasing resistance and high mortality rates. Conventional antibiotic susceptibility…”
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Novel Clinical mNGS-Based Machine Learning Model for Rapid Antimicrobial Susceptibility Testing of Acinetobacter baumannii by Hu, Xuejiao, Zhao, Yunhu, Han, Peng, Liu, Suling, Liu, Weijiang, Mai, Cong, Deng, Qianyun, Ren, Jing, Luo, Jiajie, Chen, Fangyuan, Jia, Xuefeng, Zhang, Jing, Rao, Guanhua, Gu, Bing

“…Multidrug-resistant (MDR) bacteria are important public health problems. Antibiotic susceptibility testing (AST) currently uses time-consuming culture-based…”
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Direct prediction of carbapenem resistance in Pseudomonas aeruginosa by whole genome sequencing and metagenomic sequencing by Liu, Bing, Gao, Jianpeng, Liu, Xue Fei, Rao, Guanhua, Luo, Jiajie, Han, Peng, Hu, Weiting, Zhang, Ze, Zhao, Qianqian, Han, Lizhong, Jiang, Zhi, Zhou, Min

“…Carbapenem resistance is a major concern in the management of antibiotic-resistant infections. The direct prediction of carbapenem-resistant phenotype from…”
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Clinical metagenomic sequencing of plasma microbial cell-free DNA for febrile neutropenia in patients with acute leukaemia by Feng, Sizhou, Rao, Guanhua, Wei, Xudong, Fu, Rong, Hou, Ming, Song, Yongping, Xu, Chunhui, Han, Peng, Gong, Benfa, Chen, Xin, Wang, Yihao, Dong, Xiaoyuan, Jiang, Zhi, Wang, Jianxiang

“…To evaluate the diagnostic performance and clinical impact of metagenomic next-generation sequencing (mNGS) of plasma microbial cell-free DNA (mcfDNA) in…”
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Dasatinib sensitises KRAS-mutant cancer cells to mitogen-activated protein kinase kinase inhibitor via inhibition of TAZ activity by Rao, Guanhua, Kim, In-kyu, Conforti, Fabio, Liu, Jing, Zhang, Yu-Wen, Giaccone, Giuseppe

“…Oncogenic KRAS mutations occur frequently in solid tumours, but no clinically applicable targeted strategy is yet available for treating human cancers with…”
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