Search Results - "GUANGCHUN CHEN"

IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells by Wong, Victoria A, Dinh, Kristie N, Chen, Guangchun, Wrenshall, Lucile E

“…IL-2Rα knock out (KO) mice have been instrumental to discovering the immunoregulatory properties of IL-2Rα. While initially thought of only as a stimulatory…”
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GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression by LIQUAN YANG, GUANGCHUN CHEN, MOHANTY, Sonali, SCOTT, Glynis, FAZAL, Fabeha, RAHMAN, Arshad, BEGUM, Shahinoor, HYNES, Richard O, LEI XU

“…Angiogenesis is a critical step during cancer progression. The VEGF is a major stimulator for angiogenesis and is predominantly contributed by cancer cells in…”
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Antiviral immunity in amphibians by Chen, Guangchun, Robert, Jacques

“…Although a variety of virus species can infect amphibians, diseases caused by ranaviruses ([RVs]; Iridoviridae) have become prominent, and are a major concern…”
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Improved Knockout Methodology Reveals That Frog Virus 3 Mutants Lacking either the 18K Immediate-Early Gene or the Truncated vIF-2α Gene Are Defective for Replication and Growth In Vivo by GUANGCHUN CHEN, WARD, Brian M, YU, Kwang H, CHINCHAR, V. Gregory, ROBERT, Jacques

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor by Chen, Guangchun, Goto, Yutaka, Sakamoto, Ryuichi, Tanaka, Kimitaka, Matsubara, Eri, Nakamura, Masafumi, Zheng, Hong, Lu, Jian, Takayanagi, Ryoichi, Nomura, Masatoshi

“…► GLI1, which play a central role in sonic hedgehog signaling in prostate cancer, can act as a co-repressor to substantially block androgen receptor-mediated…”
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Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing by Gong, Binsheng, Li, Dan, Łabaj, Paweł P., Pan, Bohu, Novoradovskaya, Natalia, Thierry-Mieg, Danielle, Thierry-Mieg, Jean, Chen, Guangchun, Bergstrom Lucas, Anne, LoCoco, Jennifer S., Richmond, Todd A., Tseng, Elizabeth, Kusko, Rebecca, Happe, Scott, Mercer, Timothy R., Pabón-Peña, Carlos, Salmans, Michael, Tilgner, Hagen U., Xiao, Wenzhong, Johann, Donald J., Jones, Wendell, Tong, Weida, Mason, Christopher E., Kreil, David P., Xu, Joshua

“…Next-generation sequencing (NGS) has revolutionized genomic research by enabling high-throughput, cost-effective genome and transcriptome sequencing…”
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Comprehensive microRNA-seq transcriptomic profiling across 11 organs, 4 ages, and 2 sexes of Fischer 344 rats by Yao, Xintong, Sun, Shanyue, Zi, Yi, Liu, Yaqing, Yang, Jingcheng, Ren, Luyao, Chen, Guangchun, Cao, Zehui, Hou, Wanwan, Song, Yueqiang, Shang, Jun, Jiang, He, Li, Zhihui, Wang, Haiyan, Zhang, Peipei, Shi, Leming, Li, Quan-Zhen, Yu, Ying, Zheng, Yuanting

“…Rat is one of the most widely-used models in chemical safety evaluation and biomedical research. However, the knowledge about its microRNA (miRNA) expression…”
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Immune evasion strategies of ranaviruses and innate immune responses to these emerging pathogens by Grayfer, Leon, Andino, Francisco De Jesús, Chen, Guangchun, Chinchar, Gregory V, Robert, Jacques

“…Ranaviruses (RV, Iridoviridae) are large double-stranded DNA viruses that infect fish, amphibians and reptiles. For ecological and commercial reasons,…”
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Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA by Willey, James C., Morrison, Tom B., Austermiller, Bradley, Crawford, Erin L., Craig, Daniel J., Blomquist, Thomas M., Jones, Wendell D., Wali, Aminah, Lococo, Jennifer S., Haseley, Nathan, Richmond, Todd A., Novoradovskaya, Natalia, Kusko, Rebecca, Chen, Guangchun, Li, Quan-Zhen, Johann, Donald J., Deveson, Ira W., Mercer, Timothy R., Wu, Leihong, Xu, Joshua

“…The primary objective of the FDA-led Sequencing and Quality Control Phase 2 (SEQC2) project is to develop standard analysis protocols and quality control…”
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Activating the expression of human K-rasG12D stimulates oncogenic transformation in transgenic goat fetal fibroblast cells by Gong, Jianhua, Wang, Zhongde, Polejaeva, Irina, Salgia, Ravi, Kao, Chien-Min, Chen, Chin-Tu, Chen, Guangchun, Chen, Liaohai

“…Humane use of preclinical large animal cancer models plays a critical role in understanding cancer biology and developing therapeutic treatments. Among the…”
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Determination of oxymatrine and its metabolite matrine in rat blood and dermal microdialysates by high throughput liquid chromatography/tandem mass spectrometry by Zheng, Hong, Chen, Guangchun, Shi, Lifu, Lou, Ziyang, Chen, Fangjian, Hu, Jinhong

“…Oxymatrine (OMT) and matrine (MT) are the major quinolizidine alkaloids found in certain Sophora plants, which have been extensively used in China for the…”
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Glucocorticoid Up-Regulates Transforming Growth Factor-β (TGF-β) Type II Receptor and Enhances TGF-β Signaling in Human Prostate Cancer PC-3 Cells by Li, Zongbin, Chen, Yuxia, Cao, Dongmei, Wang, Yan, Chen, Guangchun, Zhang, Shimin, Lu, Jian

“…Previous studies have shown that dexamethasone (Dex) induces the expression of TGF-β1 in androgen-independent prostate cancer both in vitro and in vivo…”
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Environmental Information Disclosure, Digital Transformation, and Total Factor Productivity: Evidence from Chinese Heavy Polluting Listed Companies by Liu, Hongnan, Liu, Weili, Chen, Guangchun

“…Environmental information disclosure, as a new environmental regulatory model, is important for achieving collaborative environmental pollution management and…”
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Novel method for identifying sensitive geometric errors of CNC machine tools oriented to cylindricity in flank milling by Chen, Guangchun, Ding, Shuang, Xu, Guicai

“…Parts machining accuracy is greatly affected by the machine tool geometric errors. According to geometrical product specification (GPS), the evaluation…”
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Androgen receptor mutants detected in recurrent prostate cancer exhibit diverse functional characteristics by Chen, Guangchun, Wang, Xiaohui, Zhang, Shimin, Lu, Ying, Sun, Yinghao, Zhang, Jinshan, Li, Zongbin, Lu, Jian

“…BACKGROUND Alterations in the function of androgen receptor (AR) and its signaling pathway may be responsible for the progression of prostate cancer. The goal…”
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Efficient pH-universal aqueous supercapacitors enabled by an azure C-decorated N-doped graphene aerogel by Wu, Chenghan, Zhu, Jiawan, Zhang, Buyuan, Shi, Hucheng, Zhang, Hui, Yuan, Saisai, Yin, Yu, Chen, Guangchun, Chen, Chuanxiang

“…[Display omitted] •An azure C/N-doped graphene aerogel (AC/NGA) is prepared via a hydrothermal method.•AC molecules graft onto NGA by strong non-covalent π-π…”
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Aniline tetramer conjugated N-doped graphene aerogel enabling efficient pH-universal aqueous supercapacitors by Zhang, Buyuan, Wu, Chenghan, Bao, Yan, Zou, Pingfan, Wang, Xijuan, Yuan, Saisai, Chen, Guangchun, Chen, Chuanxiang

“…Aqueous supercapacitors have attracted enormous attention from academic and industry communities. However, the development of aqueous supercapacitors is…”
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Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor by Fan, Shuli, Goto, Kiminobu, Chen, Guangchun, Morinaga, Hidetaka, Nomura, Masatoshi, Okabe, Taijiro, Nawata, Hajime, Yanase, Toshihiko

“…Previously, we identified a transcriptional coactivator for the activation function-1 (AF-1) domain of the human androgen receptor (AR) and designated it…”
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Bioaccessibility of BDE 47 in a simulated gastrointestinal system and its metabolic transformation mechanisms in Caco-2 cells by Chen, Guangchun, Jiang, Xiaofeng, Gu, Chenggang, Sun, Cheng, Li, Mei

“…Polybrominated diphenyl ethers (PBDEs) have been regarded as ubiquitous environmental pollutants. However, the absorption and transformation of these compounds…”
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Modulation of Androgen Receptor Transactivation by FoxH1 by Chen, Guangchun, Nomura, Masatoshi, Morinaga, Hidetaka, Matsubara, Eri, Okabe, Taijiro, Goto, Kiminobu, Yanase, Toshihiko, Zheng, Hong, Lu, Jian, Nawata, Hajime

“…Androgen signaling plays key roles in the development and progression of prostate cancer, and numerous ongoing studies focus on the regulation of androgen…”
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