Search Results - "GUALERZI, Alice"
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Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure
Published in Acta neuropathologica (01-12-2019)“…Microglia are highly plastic immune cells which exist in a continuum of activation states. By shaping the function of oligodendrocyte precursor cells (OPCs),…”
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Extracellular Vesicles as Biomarkers for Parkinson's Disease: How Far from Clinical Translation?
Published in International journal of molecular sciences (01-01-2024)“…Parkinson's disease (PD) is a neurodegenerative disorder affecting about 10 million people worldwide with a prevalence of about 2% in the over-80 population…”
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Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue
Published in Diabetes (New York, N.Y.) (01-03-2013)“…Chromatin modifications are sensitive to environmental and nutritional stimuli. Abnormalities in epigenetic regulation are associated with metabolic disorders…”
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Neuromuscular electrical stimulation enhances the ability of serum extracellular vesicles to regenerate aged skeletal muscle after injury
Published in Experimental gerontology (15-06-2023)“…Exercise promotes healthy aging of skeletal muscle. This benefit may be mediated by youthful factors in the circulation released in response to an exercise…”
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Multiplexing Biosensor for the Detection of Extracellular Vesicles as Biomarkers of Tissue Damage and Recovery after Ischemic Stroke
Published in International journal of molecular sciences (27-04-2023)“…The inflammatory, reparative and regenerative mechanisms activated in ischemic stroke patients immediately after the event cooperate in the response to injury,…”
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Raman spectroscopy as a quick tool to assess purity of extracellular vesicle preparations and predict their functionality
Published in Journal of extracellular vesicles (01-12-2019)“…Extracellular vesicles (EVs) from a variety of stem cell sources are believed to harbour regenerative capacity, which may be exploited for therapeutic…”
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Microglia-oligodendrocyte intercellular communication: role of extracellular vesicle lipids in functional signalling
Published in Neural regeneration research (01-06-2021)Get full text
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Extracellular Vesicles in Regeneration and Rehabilitation Recovery after Stroke
Published in Biology (Basel, Switzerland) (30-08-2021)“…Patients that survive after a stroke event may present disabilities that can persist for a long time or permanently after it. If stroke prevention fails, the…”
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Taking the Next Steps in Regenerative Rehabilitation: Establishment of a New Interdisciplinary Field
Published in Archives of physical medicine and rehabilitation (01-05-2020)“…The growing field of regenerative rehabilitation has great potential to improve clinical outcomes for individuals with disabilities. However, the science to…”
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Differential Proteomic Analysis Predicts Appropriate Applications for the Secretome of Adipose-Derived Mesenchymal Stem/Stromal Cells and Dermal Fibroblasts
Published in Stem cells international (01-01-2018)“…The adult stem cell secretome is currently under investigation as an alternative to cell-based therapy in regenerative medicine, thanks to the remarkable…”
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Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles
Published in Journal of extracellular vesicles (01-12-2019)“…ABSTRACT There is an increasing interest in exploring clinically relevant information that is present in body fluids, and extracellular vesicles (EVs) are…”
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Advances in the Field of Micro- and Nanotechnologies Applied to Extracellular Vesicle Research: Take-Home Message from ISEV2021
Published in Micromachines (16-12-2021)“…Extracellular Vesicles (EVs) are naturally secreted nanoparticles with a plethora of functions in the human body and remarkable potential as diagnostic and…”
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Plasma-derived extracellular vesicles released after endurance exercise exert cardioprotective activity through the activation of antioxidant pathways
Published in Redox biology (01-07-2023)“…Cardiovascular diseases (CVD) can cause various conditions, including an increase in reactive oxygen species (ROS) levels that can decrease nitric oxide (NO)…”
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Identification of the Raman Salivary Fingerprint of Parkinson's Disease Through the Spectroscopic- Computational Combinatory Approach
Published in Frontiers in neuroscience (26-10-2021)“…Despite the wide range of proposed biomarkers for Parkinson's disease (PD), there are no specific molecules or signals able to early and uniquely identify the…”
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Towards Secretome Standardization: Identifying Key Ingredients of MSC-Derived Therapeutic Cocktail
Published in Stem cells international (2021)“…The therapeutic potential of the conditioned medium (CM) derived from MSCs (mesenchymal stem/stromal cells) in disparate medical fields, from immunology to…”
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Extracellular vesicles released by microglia and macrophages carry endocannabinoids which foster oligodendrocyte differentiation
Published in Frontiers in immunology (2024)“…Microglia and macrophages can influence the evolution of myelin lesions through the production of extracellular vesicles (EVs). While microglial EVs promote in…”
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Raman Fingerprint of Extracellular Vesicles and Conditioned Media for the Reproducibility Assessment of Cell-Free Therapeutics
Published in Frontiers in bioengineering and biotechnology (13-04-2021)“…Extracellular Vesicles (EVs) and Conditioned Medium (CM) are promising cell-free approaches to repair damaged and diseased tissues for regenerative…”
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Biochemical Characterization of Human Salivary Extracellular Vesicles as a Valuable Source of Biomarkers
Published in Biology (Basel, Switzerland) (31-01-2023)“…Extracellular vesicles (EVs) are natural nanoparticles secreted under physiological and pathological conditions. Thanks to their diagnostic potential, EVs are…”
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Comparing the effects of augmented virtual reality treadmill training versus conventional treadmill training in patients with stage II-III Parkinson's disease: the VIRTREAD-PD randomized controlled trial protocol
Published in Frontiers in neurology (2024)“…Intensive treadmill training (TT) has been documented to improve gait parameters and functional independence in Parkinson's Disease (PD), but the optimal…”
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MIBlood‐EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research
Published in Journal of extracellular vesicles (01-12-2023)“…Blood is the most commonly used body fluid for extracellular vesicle (EV) research. The composition of a blood sample and its derivatives (i.e., plasma and…”
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