Search Results - "GRUYS, Eilene"

Nitric Oxide Is a Key Component in Inflammation-Accelerated Tumorigenesis by PERWEZ HUSSAIN, S, PEIJUN HE, MATHE, Ewy, DJURICKOVIC, Draginja, HAINES, Diana, WEISS, Jonathan, BACK, Timothy, GRUYS, Eilene, LAUBACH, Victor E, WILTROUT, Robert H, HARRIS, Curtis C, SUBLESKI, Jeffery, HOFSETH, Lorne J, TRIVERS, Glenwood E, MECHANIC, Leah, HOFSETH, Anne B, BERNARD, Mark, SCHWANK, Jonathan, NGUYEN, Giang

“…Nitric oxide (NO(*)), an important signaling molecule and a component of inflammatory response, is involved in tumorigenesis. However, the quantity of NO(*)…”
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Combination Therapy of an Orthotopic Renal Cell Carcinoma Model Using Intratumoral Vector-Mediated Costimulation and Systemic Interleukin-2 by Kudo-Saito, Chie, Wansley, Elizabeth K., Gruys, M. Eilene, Wiltrout, Robert, Schlom, Jeffrey, Hodge, James W.

“…Purpose: Interleukin (IL)-2 therapy is currently used for therapy of renal cell carcinoma (RCC). However, it is only effective in approximately 10% to 15% of…”
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IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy by Wigginton, J M, Gruys, E, Geiselhart, L, Subleski, J, Komschlies, K L, Park, J W, Wiltrout, T A, Nagashima, K, Back, T C, Wiltrout, R H

“…Systemic administration of IL-12 and intermittent doses of IL-2 induce complete regression of metastatic murine renal carcinoma. Here, we show that overt tumor…”
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Flavone acetic acid directly induces expression of cytokine genes in mouse splenic leukocytes but not in human peripheral blood leukocytes by FUTAMI, H, EADER, L. A, KOMSCHLIES, K. L, BULL, R, GRUYS, M. E, ORTALDO, J. R, YOUNG, H. A, WILTROUT, R. H

“…Flavone-8-acetic acid (FAA) is a flavonoid drug that augments mouse natural killer activity, induces cytokine gene expression, and synergizes with recombinant…”
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Prevention of acute chemotherapy-induced death in mice by recombinant human interleukin 1 : protection from hematological and nonhematological toxicities by DAMIA, G, KOMSCHLIES, K. L, FUTAMI, H, BACK, T, EILENE GRUYS, M, LONGO, D. L, KELLER, J. R, RUSCETTI, F. W, WILTROUT, R. H

“…Previous studies have demonstrated that interleukin 1 (IL-1) can protect most mice from the acute lethal toxicity mediated by high doses of radiation and/or…”
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Effects of Trypan Blue Treatment on the Immune Responses of Mice by Kripke, M L, Norbury, K C, Gruys, E, Hibbs, Jr, J B

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Combination therapy of an orthotopic renal cell carcinoma model using intratumoral vector-mediated costimulation and systemic lnterleukin-2 by KUDO-SAITO, Chie, WANSLEY, Elizabeth K, GRUYS, M. Eilene, WILTROUT, Robert, SCHLOM, Jeffrey, HODGE, James W

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Friend or Foe? IFNγ Mediates Pro-Metastatic Gene Expression in the Tumor Microenvironment (48.34) by Hall, Veronica L, Subleski, Jeff, Back, Tim C, Gruys, M. Eilene, Shorts-Cary, Lynnette, Weiss, Jonathan M., Wiltrout, Robert H

“…Abstract Several immunotherapeutic models have shown that interferon gamma (IFNγ) is required for tumor regression. Treatment with IFNγ as a sole therapy,…”
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Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin by Fidler, I J, Gruys, E, Cifone, M A, Barnes, Z, Bucana, C

“…The purpose of these studies was to examine whether the metastatic heterogeneity that is frequently found in serially transplanted neoplasms could be observed…”
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Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin by Kripke, M L, Gruys, E, Fidler, I J

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Complete Regression of Established Spontaneous Mammary Carcinoma and the Therapeutic Prevention of Genetically Programmed Neoplastic Transition by IL-12/Pulse IL-2: Induction of Local T Cell Infiltration, Fas/Fas Ligand Gene Expression, and Mammary Epithelial Apoptosis by Wigginton, Jon M, Park, Jong-Wook, Gruys, M. Eilene, Young, Howard A, Jorcyk, Cheryl L, Back, Timothy C, Brunda, Michael J, Strieter, Robert M, Ward, Jerrold, Green, Jeffrey E, Wiltrout, Robert H

“…Using a novel transgenic mouse model of spontaneous mammary carcinoma, we show here that the IL-12/pulse IL-2 combination can induce rapid and complete…”
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Cytokine induction and therapeutic synergy with interleukin-2 against murine renal and colon cancers by xanthenone-4-acetic acid derivatives by Futami, H, Eader, L, Back, T T, Gruys, E, Young, H A, Wiltrout, R H, Baguley, B C

“…Derivatives of xanthenone-4-acetic acid (XAA) have been found to have similar activity to flavone-8-acetic acid against transplantable solid tumors. Some of…”
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Primary hepatocytes from mice treated with IL-2/IL-12 produce T cell chemoattractant activity that is dependent on monokine induced by IFN-gamma (Mig) and chemokine responsive to gamma-2 (Crg-2) by Park, J W, Gruys, M E, McCormick, K, Lee, J K, Subleski, J, Wigginton, J M, Fenton, R G, Wang, J M, Wiltrout, R H

“…The IFN-gamma-inducible proteins monokine induced by IFN-gamma (Mig) and chemokine responsive to gamma-2 (Crg-2) can contribute to IL-12-induced antiangiogenic…”
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Augmentation of natural cell activity in tumor-bearing and normal mice by MVE-2 by BUDZYNSKI, W, CHIRIGOS, M, GRUYS, E

“…Mice bearing advanced Lewis lung carcinoma were found to have significantly decreased natural killer (NK) cell activity in spleen and blood. The same pattern…”
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Systemic alkalinization inhibits the ability of flavone acetic acid to augment natural killer activity, induce cytokine gene expression, and synergize with interleukin 2 for the treatment of murine renal cancer by Futami, H, Hornung, R L, Back, T T, Bull, R, Gruys, E, Wiltrout, R H

“…Flavone acetic acid (FAA) is an investigational drug that augments natural killer activity, induces the genes for alpha- and gamma-interferon (IFN) and tumor…”
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Induction of transplantable mouse renal cell cancers by streptozotocin : In vivo growth, metastases, and angiogenic phenotype by GRUYS, M. Eilene, BACK, Timothy C, WILTROUT, Robert H, SUBLESKI, Jeff, WILTROUT, Theresa A, LEE, Jong-Keuk, SCHMIDT, Laura, WATANABE, Morihiro, STANYON, Roscoe, WARD, Jerrold M, WIGGINTON, Jon M

“…Interleukin-2-based regimens of biological therapy have shown some clinical promise for the treatment of kidney cancer in humans, although the mechanisms…”
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Administration of recombinant human IL-7 to mice alters the composition of B-lineage cells and T cell subsets, enhances T cell function, and induces regression of established metastases by Komschlies, KL, Gregorio, TA, Gruys, ME, Back, TC, Faltynek, CR, Wiltrout, RH

“…These studies investigate the effects of exogenously administered recombinant human IL-7 (rhIL-7) on mouse leukocyte subsets in vivo in normal and…”
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Murine T-cell hybridomas that produce lymphokine with macrophage-activating factor activity as a constitutive product by Erickson, K L, Cicurel, L, Gruys, E, Fidler, I J

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Primary Hepatocytes from Mice Treated with IL-2/IL-12 Produce T Cell Chemoattractant Activity that Is Dependent on Monokine Induced by IFN-{{gamma}} (Mig) and Chemokine Responsive to {{gamma}}-2 (Crg-2) by Park, Jong-Wook, Gruys, M. Eilene, McCormick, Kathy, Lee, Jong-Keuk, Subleski, Jeffrey, Wigginton, Jon M, Fenton, Robert G, Wang, Ji-Ming, Wiltrout, Robert H

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In vivo distribution and cytokine gene expression by enriched mouse LAK effector cells by FUTAMI, H, PILARO, A. M, GRUYS, M. E, BACK, T. C, YOUNG, H. A, WILTROUT, R. H

“…Lymphokine activated killer (LAK) cells administered in combination with interleukin 2 (IL2) can mediate antitumor activity in tumor-bearing mice and advanced…”
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