Search Results - "GRUNEWALD, Thomas G. P"

LASP1, a Newly Identified Melanocytic Protein with a Possible Role in Melanin Release, but Not in Melanoma Progression by Vaman V S, Anjana, Poppe, Heiko, Houben, Roland, Grunewald, Thomas G P, Goebeler, Matthias, Butt, Elke

“…The LIM and SH3 protein 1 (LASP1) is a focal adhesion protein. Its expression is increased in many malignant tumors. However, little is known about the…”
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The LIM and SH3 domain protein family: structural proteins or signal transducers or both? by Grunewald, Thomas G P, Butt, Elke

“…LIM and SH3 Protein 1 (LASP-1) was initially identified from a cDNA library of metastatic axillary lymph nodes (MLN) more than a decade ago. It was found to be…”
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Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration by Hailer, Amelie, Grunewald, Thomas G P, Orth, Martin, Reiss, Cora, Kneitz, Burkhard, Spahn, Martin, Butt, Elke

“…Several studies have linked overexpression of the LIM and SH3 domain protein 1 (LASP1) to progression of breast, colon, liver, and bladder cancer. However, its…”
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G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1 by Richter, Günther HS, Fasan, Annette, Hauer, Kristina, Grunewald, Thomas GP, Berns, Colette, Rössler, Sabine, Naumann, Ivonne, Staege, Martin S., Fulda, Simone, Esposito, Irene, Burdach, Stefan

“…Metastatic spread in Ewing sarcomas (ES) is frequent and haematogenous. G‐protein coupled receptor 64 (GPR64), an orphan receptor with normal expression…”
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Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays by Willier, Semjon, Butt, Elke, Grunewald, Thomas G. P.

“…ABSTRACT Lysophosphatidic acid (LPA) is a ubiquitously present signalling molecule involved in diverse cellular processes such as cell migration, proliferation…”
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YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1 by Somasekharan, Syam Prakash, El-Naggar, Amal, Leprivier, Gabriel, Cheng, Hongwei, Hajee, Shamil, Grunewald, Thomas G P, Zhang, Fan, Ng, Tony, Delattre, Olivier, Evdokimova, Valentina, Wang, Yuzhuo, Gleave, Martin, Sorensen, Poul H

“…Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is to sequester and silence mRNAs in ribonucleoprotein complexes…”
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Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis by El-Naggar, Amal M., Veinotte, Chansey J., Cheng, Hongwei, Grunewald, Thomas G.P., Negri, Gian Luca, Somasekharan, Syam Prakash, Corkery, Dale P., Tirode, Franck, Mathers, Joan, Khan, Debjit, Kyle, Alastair H., Baker, Jennifer H., LePard, Nancy E., McKinney, Steven, Hajee, Shamil, Bosiljcic, Momir, Leprivier, Gabriel, Tognon, Cristina E., Minchinton, Andrew I., Bennewith, Kevin L., Delattre, Olivier, Wang, Yuzhuo, Dellaire, Graham, Berman, Jason N., Sorensen, Poul H.

“…Metastatic dissemination is the leading cause of death in cancer patients, which is particularly evident for high-risk sarcomas such as Ewing sarcoma,…”
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An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein by Orth, Martin F, Cazes, Alex, Butt, Elke, Grunewald, Thomas G P

“…The gene encoding the LIM and SH3 domain protein (LASP1) was cloned two decades ago from a cDNA library of breast cancer metastases. As the first protein of a…”
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Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility by Machiela, Mitchell J., Grünewald, Thomas G. P., Surdez, Didier, Reynaud, Stephanie, Mirabeau, Olivier, Karlins, Eric, Rubio, Rebeca Alba, Zaidi, Sakina, Grossetete-Lalami, Sandrine, Ballet, Stelly, Lapouble, Eve, Laurence, Valérie, Michon, Jean, Pierron, Gaelle, Kovar, Heinrich, Gaspar, Nathalie, Kontny, Udo, González-Neira, Anna, Picci, Piero, Alonso, Javier, Patino-Garcia, Ana, Corradini, Nadège, Bérard, Perrine Marec, Freedman, Neal D., Rothman, Nathaniel, Dagnall, Casey L., Burdett, Laurie, Jones, Kristine, Manning, Michelle, Wyatt, Kathleen, Zhou, Weiyin, Yeager, Meredith, Cox, David G., Hoover, Robert N., Khan, Javed, Armstrong, Gregory T., Leisenring, Wendy M., Bhatia, Smita, Robison, Leslie L., Kulozik, Andreas E., Kriebel, Jennifer, Meitinger, Thomas, Metzler, Markus, Hartmann, Wolfgang, Strauch, Konstantin, Kirchner, Thomas, Dirksen, Uta, Morton, Lindsay M., Mirabello, Lisa, Tucker, Margaret A., Tirode, Franck, Chanock, Stephen J., Delattre, Olivier

“…Ewing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1 - FLI1 fusion. We performed a genome-wide association study of 733 EWS cases and 1346…”
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First report of ectopic ACTH syndrome and PTHrP-induced hypercalcemia due to a hepatoblastoma in a child by Grunewald, Thomas G P, von Luettichau, Irene, Welsch, Ulrich, Dörr, Helmuth-Günther, Höpner, Frank, Kovacs, Kalman, Burdach, Stefan, Rabl, Wolfgang

“…ContextOnly occasionally, endocrine-active tumors develop directly from hepatic tissue, and may lead to paraneoplastic syndromes (PNS). PNS mostly accompany…”
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DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma by HAUER, Kristina, CALZADA-WACK, Julia, RICHTER, Günther H. S, STEIGER, Katja, GRUNEWALD, Thomas G. P, BAUMHOER, Daniel, PLEHM, Stephanie, BUCH, Thorsten, DA COSTA, Olivia Prazeres, ESPOSITO, Irene, BURDACH, Stefan

“…Ewing sarcoma, an osteolytic malignancy that mainly affects children and young adults, is characterized by early metastasis to lung and bone. In this study, we…”
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Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma by Kim, Yong Ryoul, Joo, Jaegeon, Lee, Hee Jung, Kim, Chaelim, Park, Ju-Chan, Yu, Young Suk, Kim, Chang Rok, Lee, Do Hui, Cha, Joowon, Kwon, Hyemin, Hanssen, Kimberley M., Grünewald, Thomas G. P., Choi, Murim, Han, Ilkyu, Bae, Sangsu, Jung, Inkyung, Shin, Yongdae, Baek, Sung Hee

“…Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles within cells, with implications in various biological processes and…”
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Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides by Jin, Darui, Liang, Shangying, Shmatko, Artem, Arnold, Alexander, Horst, David, Grünewald, Thomas G. P., Gerstung, Moritz, Bai, Xiangzhi

“…Programmed cell death ligand 1 (PDL1), as an important biomarker, is quantified by immunohistochemistry (IHC) with few established histopathological patterns…”
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Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies by Knott, Maximilian M. L., Hölting, Tilman L. B., Ohmura, Shunya, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.

“…While sarcomas account for approximately 1% of malignant tumors of adults, they are particularly more common in children and adolescents affected by cancer. In…”
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Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma by Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F, Li, Jing, Jabar, Susanne, Ranft, Andreas, Vinca, Endrit, Ceranski, Katharina, Carreño-Gonzalez, Martha J, Romero-Pérez, Laura, Wehweck, Fabienne S, Musa, Julian, Bestvater, Felix, Knott, Maximilian M L, Hölting, Tilman L B, Hartmann, Wolfgang, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G P

“…Keywords: Ewing sarcoma, RRM2, Targeted therapy, Prognostic biomarker, Paediatric oncology, Triapine, Chemoresistance…”
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A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas by Orth, Martin F., Buecklein, Veit Leonhard, Kampmann, Eric, Subklewe, Marion, Noessner, Elfriede, Cidre-Aranaz, Florencia, Romero-Pérez, Laura, Wehweck, Fabienne Sophie, Lindner, Lars, Issels, Rolf, Kirchner, Thomas, Altendorf-Hofmann, Annelore, Grünewald, Thomas G. P., Knösel, Thomas

“…Soft tissue sarcomas (STSs) are heterogeneous cancers associated with poor prognosis due to high rates of local recurrence and metastasis. The programmed death…”
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Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung by Martins, Leila R., Sieverling, Lina, Michelhans, Michelle, Schiller, Chiara, Erkut, Cihan, Grünewald, Thomas G. P., Triana, Sergio, Fröhling, Stefan, Velten, Lars, Glimm, Hanno, Scholl, Claudia

“…Understanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of therapeutic approaches for lung…”
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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma by Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

“…Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by…”
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mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism by Levy, Tal, Voeltzke, Kai, Hruby, Laura, Alasad, Khawla, Bas, Zuelal, Snaebjörnsson, Marteinn, Marciano, Ran, Scharov, Katerina, Planque, Mélanie, Vriens, Kim, Christen, Stefan, Funk, Cornelius M., Hassiepen, Christina, Kahler, Alisa, Heider, Beate, Picard, Daniel, Lim, Jonathan K. M., Stefanski, Anja, Bendrin, Katja, Vargas-Toscano, Andres, Kahlert, Ulf D., Stühler, Kai, Remke, Marc, Elkabets, Moshe, Grünewald, Thomas G. P., Reichert, Andreas S., Fendt, Sarah-Maria, Schulze, Almut, Reifenberger, Guido, Rotblat, Barak, Leprivier, Gabriel

“…Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism. Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell…”
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Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship by Ceranski, A Katharina, Carreño-Gonzalez, Martha J, Ehlers, Anna C, Colombo, Maria Vittoria, Cidre-Aranaz, Florencia, Grünewald, Thomas G P

“…Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone…”
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