Search Results - "GRUARIN, Paola"

Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ by Della Chiara, Giulia, Gervasoni, Federica, Fakiola, Michaela, Godano, Chiara, D’Oria, Claudia, Azzolin, Luca, Bonnal, Raoul Jean Pierre, Moreni, Giulia, Drufuca, Lorenzo, Rossetti, Grazisa, Ranzani, Valeria, Bason, Ramona, De Simone, Marco, Panariello, Francesco, Ferrari, Ivan, Fabbris, Tanya, Zanconato, Francesca, Forcato, Mattia, Romano, Oriana, Caroli, Jimmy, Gruarin, Paola, Sarnicola, Maria Lucia, Cordenonsi, Michelangelo, Bardelli, Alberto, Zucchini, Nicola, Ceretti, Andrea Pisani, Mariani, Nicolò Maria, Cassingena, Andrea, Sartore-Bianchi, Andrea, Testa, Giuseppe, Gianotti, Luca, Opocher, Enrico, Pisati, Federica, Tripodo, Claudio, Macino, Giuseppe, Siena, Salvatore, Bicciato, Silvio, Piccolo, Stefano, Pagani, Massimiliano

“…Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and…”
Get full text

Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response by Pesce, Elisa, Manfrini, Nicola, Cordiglieri, Chiara, Santi, Spartaco, Bandera, Alessandra, Gobbini, Andrea, Gruarin, Paola, Favalli, Andrea, Bombaci, Mauro, Cuomo, Alessandro, Collino, Federica, Cricrì, Giulia, Ungaro, Riccardo, Lombardi, Andrea, Mangioni, Davide, Muscatello, Antonio, Aliberti, Stefano, Blasi, Francesco, Gori, Andrea, Abrignani, Sergio, De Francesco, Raffaele, Biffo, Stefano, Grifantini, Renata

“…Coronavirus disease 2019 (COVID-19) is an infectious disease caused by beta-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has…”
Get full text

TMEM123 a key player in immune surveillance of colorectal cancer by Pesce, Elisa, Cordiglieri, Chiara, Bombaci, Mauro, Eppenberger-Castori, Serenella, Oliveto, Stefania, Manara, Cristina, Crosti, Mariacristina, Ercan, Caner, Coto, Mairene, Gobbini, Andrea, Campagnoli, Susanna, Donnarumma, Tiziano, Martinelli, Manuele, Bevilacqua, Valeria, De Camilli, Elisa, Gruarin, Paola, Sarnicola, Maria L, Cassinotti, Elisa, Baldari, Ludovica, Viale, Giuseppe, Biffo, Stefano, Abrignani, Sergio, Terracciano, Luigi M, Grifantini, Renata

“…Colorectal cancer (CRC) is a leading cause of cancer-associated death. In the tumor site, the interplay between effector immune cells and cancer cells…”
Get full text

Corrigendum: TMEM123 a key player in immune surveillance of colorectal cancer by Pesce, Elisa, Cordiglieri, Chiara, Bombaci, Mauro, Eppenberger-Castori, Serenella, Oliveto, Stefania, Manara, Cristina, Crosti, Mariacristina, Ercan, Caner, Coto, Mairene, Gobbini, Andrea, Campagnoli, Susanna, Donnarumma, Tiziano, Martinelli, Manuele, Bevilacqua, Valeria, De Camilli, Elisa, Gruarin, Paola, Sarnicola, Maria L, Cassinotti, Elisa, Baldari, Ludovica, Viale, Giuseppe, Biffo, Stefano, Abrignani, Sergio, Terracciano, Luigi M, Grifantini, Renata

“…[This corrects the article DOI: 10.3389/fimmu.2023.1194087.]…”
Get full text

Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations by Favalli, Andrea, Favalli, Ennio Giulio, Gobbini, Andrea, Zagato, Elena, Bombaci, Mauro, Maioli, Gabriella, Pesce, Elisa, Donnici, Lorena, Gruarin, Paola, Biggioggero, Martina, Curti, Serena, Manganaro, Lara, Marchisio, Edoardo, Bevilacqua, Valeria, Martinovic, Martina, Fabbris, Tanya, Sarnicola, Maria Lucia, Crosti, Mariacristina, Marongiu, Laura, Granucci, Francesca, Notarbartolo, Samuele, Bandera, Alessandra, Gori, Andrea, De Francesco, Raffaele, Abrignani, Sergio, Caporali, Roberto, Grifantini, Renata

“…COVID-19 has proven to be particularly serious and life-threatening for patients presenting with pre-existing pathologies. Patients affected by rheumatic…”
Get full text

Untargeted Mass Spectrometry Approach to Study SARS-CoV-2 Proteins in Human Plasma and Saliva Proteome by Pagani, Lisa, Chinello, Clizia, Mahajneh, Allia, Clerici, Francesca, Criscuolo, Lucrezia, Favalli, Andrea, Gruarin, Paola, Grifantini, Renata, Bandera, Alessandra, Lombardi, Andrea, Ungaro, Riccardo, Muscatello, Antonio, Blasi, Francesco, Gori, Andrea, Magni, Fulvio

“…Since the start of the COVID-19 outbreak, more than four million people have died of this disease. Given its ability to provide a precise response, mass…”
Get full text

An efficient strategy to induce and maintain in vitro human T cells specific for autologous non-small cell lung carcinoma by Canderan, Glenda, Gruarin, Paola, Montagna, Daniela, Fontana, Raffaella, Campi, Gabriele, Melloni, Giulio, Traversari, Catia, Dellabona, Paolo, Casorati, Giulia

“…The efficient expansion in vitro of cytolytic CD8+ T cells (CTLs) specific for autologous tumors is crucial both for basic and translational aspects of tumor…”
Get full text

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells by De Simone, Marco, Arrigoni, Alberto, Rossetti, Grazisa, Gruarin, Paola, Ranzani, Valeria, Politano, Claudia, Bonnal, Raoul J.P., Provasi, Elena, Sarnicola, Maria Lucia, Panzeri, Ilaria, Moro, Monica, Crosti, Mariacristina, Mazzara, Saveria, Vaira, Valentina, Bosari, Silvano, Palleschi, Alessandro, Santambrogio, Luigi, Bovo, Giorgio, Zucchini, Nicola, Totis, Mauro, Gianotti, Luca, Cesana, Giancarlo, Perego, Roberto A., Maroni, Nirvana, Pisani Ceretti, Andrea, Opocher, Enrico, De Francesco, Raffaele, Geginat, Jens, Stunnenberg, Hendrik G., Abrignani, Sergio, Pagani, Massimiliano

“…Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for tumor antigens. Deeper molecular definitions of…”
Get full text

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) by Radbruch, Andreas, Abrignani, Sergio, Akdis, Mübeccel, Andrä, Immanuel, Andreata, Francesco, Bacher, Petra, Barnaba, Vincenzo, Barros‐Martins, Joana, Baumjohann, Dirk, Beccaria, Cristian G., Bernardo, David, Boardman, Dominic A., Borger, Jessica, Böttcher, Chotima, Brockmann, Leonie, Cammarata, Ilenia, Cassotta, Antonino, Chirdo, Fernando Gabriel, Christakou, Eleni, Čičin‐Šain, Luka, Corbett, Alexandra J., Cornelis, Rebecca, Cosmi, Lorenzo, De Biasi, Sara, del Zotto, Genny, Di Rosa, Francesca, Dörner, Thomas, Dutertre, Charles‐Antoine, Evrard, Maximilien, Feuerer, Markus, Fillatreau, Simon, Follo, Marie, Fröbel, Julia, Gagliani, Nicola, Galletti, Giovanni, Garbi, Natalio, Ginhoux, Florent, Godfrey, Dale I., Gruarin, Paola, Haftmann, Claudia, Hansmann, Leo, Heine, Guido, Herrmann, Martin, Huber, Samuel, Huber, Johanna E., Huehn, Jochen, Hundemer, Michael, Hwang, William Y. K., Jäck, Hans‐Martin, Jani, Peter K., Keller, Baerbel, Knop, Laura, Knopf, Jasmin, Koay, Hui‐Fern, Krueger, Andreas, Kuehne, Jenny F., Kunze‐Schumacher, Heike, Kvistborg, Pia, Lenz, Daniel, Lino, Andreia C., Liotta, Francesco, Long, Heather M., Lugli, Enrico, Maggi, Laura, Manz, Rudolf Armin, Melchers, Fritz, Melzer, Susanne, Muñoz‐Ruiz, Miguel, Muscate, Franziska, Neumann, Katrin, Ng, Lai Guan, Niedobitek, Antonia, Almeida, Larissa Nogueira, Pallett, Laura J., Pockley, A. Graham, Pujol‐Autonell, Irma, Pulvirenti, Nadia, Quatrini, Linda, Quinn, Kylie M., Radbruch, Helena, Sakaguchi, Shimon, Sanderink, Lieke, Schauer, Christine, Schildberg, Frank A., Schober, Kilian, Schoen, Janina, Schulz, Axel R., Schulze, Julia, Simonetti, Sonia, Stark, Regina, Tarnok, Attila, Tornack, Julia, Verheyden, Nikita A., Ward‐Hartstonge, Kirsten A., Waskow, Claudia, Wiedemann, Annika, Wing, James, Wirz, Oliver, Yang, Jennie H. M., Yang, Juhao

“…The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive…”
Get full text

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses by Nizzoli, Giulia, Krietsch, Jana, Weick, Anja, Steinfelder, Svenja, Facciotti, Federica, Gruarin, Paola, Bianco, Annalisa, Steckel, Bodo, Moro, Monica, Crosti, Mariacristina, Romagnani, Chiara, Stölzel, Katharina, Torretta, Sara, Pignataro, Lorenzo, Scheibenbogen, Carmen, Neddermann, Petra, De Francesco, Raffaele, Abrignani, Sergio, Geginat, Jens

“…Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α+DC are specialized to cross-prime CD8+ T cells and produce…”
Get full text

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4 by Ranzani, Valeria, Rossetti, Grazisa, Panzeri, Ilaria, Arrigoni, Alberto, Bonnal, Raoul J P, Curti, Serena, Gruarin, Paola, Provasi, Elena, Sugliano, Elisa, Marconi, Maurizio, De Francesco, Raffaele, Geginat, Jens, Bodega, Beatrice, Abrignani, Sergio, Pagani, Massimiliano

“…Long intergenic noncoding RNAs (lincRNAs) contribute to the regulation of gene expression. Pagani and colleagues identify hundreds of unique lincRNAs expressed…”
Get full text

Plasticity of human CD4 T cell subsets by Geginat, Jens, Paroni, Moira, Maglie, Stefano, Alfen, Johanna Sophie, Kastirr, Ilko, Gruarin, Paola, De Simone, Marco, Pagani, Massimiliano, Abrignani, Sergio

“…Human beings are exposed to a variety of different pathogens, which induce tailored immune responses and consequently generate highly diverse populations of…”
Get full text

Intestinal IFN-γ–producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease by Alfen, Johanna Sophie, Larghi, Paola, Facciotti, Federica, Gagliani, Nicola, Bosotti, Roberto, Paroni, Moira, Maglie, Stefano, Gruarin, Paola, Vasco, Chiara Maria, Ranzani, Valeria, Frusteri, Cristina, Iseppon, Andrea, Moro, Monica, Crosti, Maria Cristina, Gatti, Stefano, Pagani, Massimiliano, Caprioli, Flavio, Abrignani, Sergio, Flavell, Richard A., Geginat, Jens

“…IL-10 is an anti-inflammatory cytokine required for intestinal immune homeostasis. It mediates suppression of T-cell responses by type 1 regulatory T (TR1)…”
Get full text

Eomesodermin controls a unique differentiation program in human IL‐10 and IFN‐γ coproducing regulatory T cells by Gruarin, Paola, Maglie, Stefano, Simone, Marco, Häringer, Barbara, Vasco, Chiara, Ranzani, Valeria, Bosotti, Roberto, Noddings, Johanna S., Larghi, Paola, Facciotti, Federica, Sarnicola, Maria L., Martinovic, Martina, Crosti, Mariacristina, Moro, Monica, Rossi, Riccardo L., Bernardo, Maria E., Caprioli, Flavio, Locatelli, Franco, Rossetti, Grazisa, Abrignani, Sergio, Pagani, Massimiliano, Geginat, Jens

“…Whether human IL‐10‐producing regulatory T cells (“Tr1”) represent a distinct differentiation lineage or an unstable activation stage remains a key unsolved…”
Get full text

Eomesodermin‐expressing type 1 regulatory (EOMES+Tr1)‐like T cells: Basic biology and role in immune‐mediated diseases by Geginat, Jens, Vasco, Chiara, Gruarin, Paola, Bonnal, Raoul, Rossetti, Grazisa, Silvestri, Ylenia, Carelli, Elena, Pulvirenti, Nadia, Scantamburlo, Morena, Moschetti, Giorgia, Clemente, Francesca, Grassi, Fabio, Monticelli, Silvia, Pagani, Massimiliano, Abrignani, Sergio

“…Type 1 regulatory (Tr1) T cells are currently defined all T cells with regulatory functions that lack FOXP3 expression and produce IL‐10. Tr1 cells are…”
Get full text

Characterization of human CD4+EOMES+GzmK+ T‐cell subsets unveils an uncoupling of suppressive functions from IL‐10‐producing capacities by Pulvirenti, Nadia, Silvetri, Ylenia, Clemente, Francesca, Bosotti, Roberto, Carelli, Elena, Moschetti, Giorgia, Gruarin, Paola, Vasco, Chiara, Crosti, Maria Cristina, Sarnicola, Maria Lucia, Valenti, Luca, Prati, Daniele, Abrignani, Sergio, Geginat, Jens

“…Human CD4+EOMES+ T cells are heterogeneous and contain Th1‐cells, Tr1‐cells, and CD4+CTL. Tr1‐ cells and non‐classical EOMES+ Th1‐cells displayed,…”
Get full text

Synthesis, Processing, and Intracellular Transport of CD36 during Monocytic Differentiation (∗) by Alessio, Massimo, De Monte, Lucia, Scirea, Alessandra, Gruarin, Paola, Tandon, Narendra N., Sitia, Roberto

“…CD36 is an integral membrane glycoprotein expressed by several cell types, including endothelial cells of the microvasculature, erythrocytes, platelets, and…”
Get full text

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4 + T cells by the microRNA miR-125b by Abrignani, Sergio, Pagani, Massimiliano, Rossi, Riccardo L, Rossetti, Grazisa, Wenandy, Lynn, Curti, Serena, Ripamonti, Anna, Bonnal, Raoul J P, Birolo, Roberto Sciarretta, Moro, Monica, Crosti, Maria C, Gruarin, Paola, Maglie, Stefano, Marabita, Francesco, Mascheroni, Debora, Parente, Valeria, Comelli, Mario, Trabucchi, Emilio, De Francesco, Raffaele, Geginat, Jens

“…MicroRNAs are post-transcriptional regulators of gene expression. Pagani and colleagues identify specific microRNA signatures and their target genes in various…”
Get full text

Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity by Torri, Anna, Carpi, Donatella, Bulgheroni, Elisabetta, Crosti, Maria-Cristina, Moro, Monica, Gruarin, Paola, Rossi, Riccardo L., Rossetti, Grazisa, Di Vizio, Dolores, Hoxha, Mirjam, Bollati, Valentina, Gagliani, Cristina, Tacchetti, Carlo, Paroni, Moira, Geginat, Jens, Corti, Laura, Venegoni, Luigia, Berti, Emilio, Pagani, Massimiliano, Matarese, Giuseppe, Abrignani, Sergio, de Candia, Paola

“…Upon T cell receptor stimulation, CD4+ T helper (Th) lymphocytes release extracellular vesicles (EVs) containing microRNAs. However, no data are available on…”
Get full text

Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression by Bonnal, Raoul J. P., Rossetti, Grazisa, Lugli, Enrico, De Simone, Marco, Gruarin, Paola, Brummelman, Jolanda, Drufuca, Lorenzo, Passaro, Marco, Bason, Ramona, Gervasoni, Federica, Della Chiara, Giulia, D’Oria, Claudia, Martinovic, Martina, Curti, Serena, Ranzani, Valeria, Cordiglieri, Chiara, Alvisi, Giorgia, Mazza, Emilia Maria Cristina, Oliveto, Stefania, Silvestri, Ylenia, Carelli, Elena, Mazzara, Saveria, Bosotti, Roberto, Sarnicola, Maria Lucia, Godano, Chiara, Bevilacqua, Valeria, Lorenzo, Mariangela, Siena, Salvatore, Bonoldi, Emanuela, Sartore-Bianchi, Andrea, Amatu, Alessio, Veronesi, Giulia, Novellis, Pierluigi, Alloisio, Marco, Giani, Alessandro, Zucchini, Nicola, Opocher, Enrico, Ceretti, Andrea Pisani, Mariani, Nicolò, Biffo, Stefano, Prati, Daniele, Bardelli, Alberto, Geginat, Jens, Lanzavecchia, Antonio, Abrignani, Sergio, Pagani, Massimiliano

“…Regulatory T (T reg ) cells are a barrier for tumor immunity and a target for immunotherapy. Using single-cell transcriptomics, we found that CD4 + T cells…”
Get full text