Search Results - "GROVE, Megan L"

Evaluation of mitochondrial DNA copy number estimation techniques by Longchamps, Ryan J, Castellani, Christina A, Yang, Stephanie Y, Newcomb, Charles E, Sumpter, Jason A, Lane, John, Grove, Megan L, Guallar, Eliseo, Pankratz, Nathan, Taylor, Kent D, Rotter, Jerome I, Boerwinkle, Eric, Arking, Dan E

“…Mitochondrial DNA copy number (mtDNA-CN), a measure of the number of mitochondrial genomes per cell, is a minimally invasive proxy measure for mitochondrial…”
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Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci by Demerath, Ellen W, Guan, Weihua, Grove, Megan L, Aslibekyan, Stella, Mendelson, Michael, Zhou, Yi-Hui, Hedman, Åsa K, Sandling, Johanna K, Li, Li-An, Irvin, Marguerite R, Zhi, Degui, Deloukas, Panos, Liang, Liming, Liu, Chunyu, Bressler, Jan, Spector, Tim D, North, Kari, Li, Yun, Absher, Devin M, Levy, Daniel, Arnett, Donna K, Fornage, Myriam, Pankow, James S, Boerwinkle, Eric

“…Obesity is an important component of the pathophysiology of chronic diseases. Identifying epigenetic modifications associated with elevated adiposity,…”
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Association between Mitochondrial DNA Copy Number in Peripheral Blood and Incident CKD in the Atherosclerosis Risk in Communities Study by Tin, Adrienne, Grams, Morgan E, Ashar, Foram N, Lane, John A, Rosenberg, Avi Z, Grove, Megan L, Boerwinkle, Eric, Selvin, Elizabeth, Coresh, Josef, Pankratz, Nathan, Arking, Dan E

“…Mitochondrial dysfunction in kidney cells has been implicated in the pathogenesis of CKD. Mitochondrial DNA (mtDNA) copy number is a surrogate measure of…”
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A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos by Feofanova, Elena V., Chen, Han, Dai, Yulin, Jia, Peilin, Grove, Megan L., Morrison, Alanna C., Qi, Qibin, Daviglus, Martha, Cai, Jianwen, North, Kari E., Laurie, Cathy C., Kaplan, Robert C., Boerwinkle, Eric, Yu, Bing

“…Variation in levels of the human metabolome reflect changes in homeostasis, providing a window into health and disease. The genetic impact on circulating…”
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MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension by Nandakumar, Priyanka, Tin, Adrienne, Grove, Megan L, Ma, Jianzhong, Boerwinkle, Eric, Coresh, Josef, Chakravarti, Aravinda

“…In older adults (aged 70-74 years), African-Americans have 4-fold higher risk of developing hypertension-attributed end-stage renal disease (ESRD) than…”
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Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs by Castellani, Christina A, Longchamps, Ryan J, Sumpter, Jason A, Newcomb, Charles E, Lane, John A, Grove, Megan L, Bressler, Jan, Brody, Jennifer A, Floyd, James S, Bartz, Traci M, Taylor, Kent D, Wang, Penglong, Tin, Adrienne, Coresh, Josef, Pankow, James S, Fornage, Myriam, Guallar, Eliseo, O'Rourke, Brian, Pankratz, Nathan, Liu, Chunyu, Levy, Daniel, Sotoodehnia, Nona, Boerwinkle, Eric, Arking, Dan E

“…Mitochondrial DNA copy number (mtDNA-CN) has been associated with a variety of aging-related diseases, including all-cause mortality. However, the mechanism by…”
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Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality by Hong, Yun Soo, Battle, Stephanie L., Shi, Wen, Puiu, Daniela, Pillalamarri, Vamsee, Xie, Jiaqi, Pankratz, Nathan, Lake, Nicole J., Lek, Monkol, Rotter, Jerome I., Rich, Stephen S., Kooperberg, Charles, Reiner, Alex P., Auer, Paul L., Heard-Costa, Nancy, Liu, Chunyu, Lai, Meng, Murabito, Joanne M., Levy, Daniel, Grove, Megan L., Alonso, Alvaro, Gibbs, Richard, Dugan-Perez, Shannon, Gondek, Lukasz P., Guallar, Eliseo, Arking, Dan E.

“…Mitochondria carry their own circular genome and disruption of the mitochondrial genome is associated with various aging-related diseases. Unlike the nuclear…”
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Longitudinal change in blood DNA epigenetic signature after smoking cessation by Keshawarz, Amena, Joehanes, Roby, Guan, Weihua, Huan, Tianxiao, DeMeo, Dawn L., Grove, Megan L., Fornage, Myriam, Levy, Daniel, O'Connor, George

“…Cigarette smoking is associated with epigenetic changes that may be reversible following smoking cessation. Whole blood DNA methylation was evaluated in…”
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Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children by Zaman, Sheikh Farzana, Samms-Vaughan, Maureen, Saroukhani, Sepideh, Bressler, Jan, Hessabi, Manouchehr, Grove, Megan L, Pellington, Sydonnie Shakespeare, Loveland, Katherine A, Rahbar, Mohammad H

“…Jamaican soil is abundant in heavy metals including mercury (Hg). Due to availability and ease of access, fish is a traditional dietary component in Jamaica…”
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Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections by Guo, Dong-chuan, Grove, Megan L., Prakash, Siddharth K., Eriksson, Per, Hostetler, Ellen M., LeMaire, Scott A., Body, Simon C., Shalhub, Sherene, Estrera, Anthony L., Safi, Hazim J., Regalado, Ellen S., Zhou, Wei, Mathis, Michael R., Eagle, Kim A., Yang, Bo, Willer, Cristen J., Boerwinkle, Eric, Milewicz, Dianna M.

“…Acute aortic dissections are a preventable cause of sudden death if individuals at risk are identified and surgically repaired in a non-emergency setting…”
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Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers by Cunningham, Patrick N, Wang, Zhiying, Grove, Megan L, Cooper-DeHoff, Rhonda M, Beitelshees, Amber L, Gong, Yan, Gums, John G, Johnson, Julie A, Turner, Stephen T, Boerwinkle, Eric, Chapman, Arlene B

“…Hypertension (HTN) disproportionately affects African Americans (AAs), who respond better to thiazide diuretics than other antihypertensives. Variants of the…”
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Lipoprotein-associated phospholipase A2 and risk of incident peripheral arterial disease: Findings from The Atherosclerosis Risk in Communities study (ARIC) by Garg, Parveen K., Norby, Faye L., Polfus, Linda M., Boerwinkle, Eric, Gibbs, Richard A., Grove, Megan L., Folsom, Aaron R., Garimella, Pranav S., Matsushita, Kunihiro, Hoogeveen, Ron C., Ballantyne, Christie M.

“…Results from prospective studies evaluating the relationship between elevated lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and incident…”
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Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study by Raina, Abhay, Zhao, Xiaoping, Grove, Megan L, Bressler, Jan, Gottesman, Rebecca F, Guan, Weihua, Pankow, James S, Boerwinkle, Eric, Mosley, Thomas H, Fornage, Myriam

“…Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are…”
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The diagnosis of autism and autism spectrum disorder in low- and middle-income countries: Experience from Jamaica by Samms-Vaughan, Maureen, Rahbar, Mohammad H, Dickerson, Aisha S, Loveland, Katherine A, Hessabi, Manouchehr, Pearson, Deborah A, Bressler, Jan, Shakespeare-Pellington, Sydonnie, Grove, Megan L, Coore-Desai, Charlene, Reece, Jody, Boerwinkle, Eric

“…The administration requirements of the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview–Revised, widely used in high-income…”
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Chromosome 9p21 Single Nucleotide Polymorphisms Are Not Associated With Recurrent Myocardial Infarction in Patients With Established Coronary Artery Disease by Virani, Salim S., Brautbar, Ariel, Lee, Vei-Vei, Elayda, MacArthur, Morrison, Alanna C., Grove, Megan L., Nambi, Vijay, Frazier, Lorraine, Wilson, James M., Willerson, James T., Boerwinkle, Eric, Ballantyne, Christie M.

“…Background: Chromosome 9p21 single nucleotide polymorphisms (SNPs) have been shown to be associated with coronary heart disease in multiple studies. The aim of…”
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Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program by EHRET, Georg B, MORRISON, Alanna C, BOERWINKLE, Eric, CHAKRAVARTI, Aravinda, O'CONNOR, Ashley A, GROVE, Megan L, BAIRD, Lisa, SCHWANDER, Karen, WEDER, Alan, COOPER, Richard S, RAO, D. C, HUNT, Steven C

“…Essential hypertension is a principal cardiovascular risk factor whose origin remains unknown. Classical genetic studies have shown that blood pressure is at…”
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Corrigendum to ‘Association of sickle cell trait with measures of cognitive function and dementia in African Americans’ eNeurologicalSci, Vol. 16 (2019), 100,201 by Chen, Nemin, Caruso, Christina, Alonso, Alvaro, Derebail, Vimal K., Kshirsagar, Abhijit V., Sharrett, A. Richey, Key, Nigel S., Gottesman, Rebecca F., Grove, Megan L., Bressler, Jan, Boerwinkle, Eric, Windham, B. Gwen, Mosley, Thomas H., Hyacinth, Hyacinth I.

“…[This corrects the article DOI: 10.1016/j.ensci.2019.100201.]…”
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Single Nucleotide Polymorphisms in Cholesteryl Ester Transfer Protein Gene and Recurrent Coronary Heart Disease or Mortality in Patients With Established Atherosclerosis by Virani, Salim S., MD, PhD, Lee, Vei-Vei, MS, Brautbar, Ariel, MD, Grove, Megan L., MS, Nambi, Vijay, MD, PhD, Alam, Mahboob, MD, Elayda, MacArthur, MD, PhD, Wilson, James M., MD, Willerson, James T., MD, Boerwinkle, Eric, PhD, Ballantyne, Christie M., MD

“…It is not known whether genetic variants in the cholesteryl ester transfer protein (CETP) gene are associated with recurrent coronary heart disease events or…”
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Association of sickle cell trait with measures of cognitive function and dementia in African Americans by Chen, Nemin, Caruso, Christina, Alonso, Alvaro, Derebail, Vimal K., Kshirsagar, Abhijit V., Sharrett, A. Richey, Key, Nigel S., Gottesman, Rebecca F., Grove, Megan L., Bressler, Jan, Boerwinkle, Eric, Windham, B. Gwen, Mosley, Thomas H., Hyacinth, Hyacinth I.

“…The incidence and prevalence of cognitive decline and dementia are significantly higher among African Americans compared with non-Hispanic Whites. The aim of…”
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Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies by Qi, Qibin, Li, Jun, Yu, Bing, Moon, Jee-Young, Chai, Jin C, Merino, Jordi, Hu, Jie, Ruiz-Canela, Miguel, Rebholz, Casey, Wang, Zheng, Usyk, Mykhaylo, Chen, Guo-Chong, Porneala, Bianca C, Wang, Wenshuang, Nguyen, Ngoc Quynh, Feofanova, Elena V, Grove, Megan L, Wang, Thomas J, Gerszten, Robert E, Dupuis, Josée, Salas-Salvadó, Jordi, Bao, Wei, Perkins, David L, Daviglus, Martha L, Thyagarajan, Bharat, Cai, Jianwen, Wang, Tao, Manson, JoAnn E, Martínez-González, Miguel A, Selvin, Elizabeth, Rexrode, Kathryn M, Clish, Clary B, Hu, Frank B, Meigs, James B, Knight, Rob, Burk, Robert D, Boerwinkle, Eric, Kaplan, Robert C

“…Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and…”
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